Surgical Treatment of Lipomatosis of Nerve: A Systematic Review

Marek, Tomáš; Spinner, Robert J.; Syal, Akshay; Wahood, Waseem; Mahan, Mark A.

doi:10.1016/j.wneu.2019.04.110

Cited by 22 publications

(21 citation statements)

References 18 publications

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“…Overgrowth has not been observed in the subset of LN restricted to the so called predominant sensory nerves. 1 The tumor is caused by hypertrophy of mature fat and fibroblasts—due to unknown causes—within the nerve epineurium, resulting in enlargement of the affected nerve. 5 …”

Section: Discussionmentioning

confidence: 99%

“…Lipofibromatous hamartoma (LFH) is a part of a spectrum of adipose tumors of the nerve ranging from compressive external lipomas to diffuse interfascicular fibroadipose proliferation. 1 LFH is a rare benign fibro-fatty tumor characterized by the proliferation of the mature adipocytes within the epineurium and perineurium of the peripheral nerves. The etiology of such a condition is unknown but it likely has a congenital origin.…”

Section: Introductionmentioning

confidence: 99%

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Lipofibromatous Hamartoma of Digital Nerve: A Case Report

Soffar

Fadali

Ghalab

et al. 2021

Plastic and Reconstructive Surgery - Global Open

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Summary: A 9-year-old girl was investigated for a long-standing soft tissue swelling in her ring digit that recently developed tenderness and rapid growth within the last 3 months before presentation. Exploration of the swelling was done meticulously with total excision of the swelling from within its attachment to the digital nerve. The swelling was then sent for histopathological examination. The pathology report stated the presence of mature adipose tissue intersected by fiprocellular collagenic stroma infiltrating perineurium, epineurium, and nerve fascicles, which established the diagnosis of lipofipromatous hamartoma (LFH) of the nerve. LFH is a rare benign neoplasm that mainly affects the median nerve, but other nerves all over the body were also reported. Women are more affected than men.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipofibromatous Hamartoma of Digital Nerve: A Case Report

Soffar

Fadali

Ghalab

et al. 2021

Plastic and Reconstructive Surgery - Global Open

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“…The treatment of fibrolipoma is not codified. Several treatments may be suggested, such as neurolysis, epineurotomy, or an excision [5].…”

Section: Discussionmentioning

confidence: 99%

Carpal tunnel syndrome revealing a fibrolipoma of the median nerve

et al. 2021

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“…The profound atrophy of the hand intrinsic muscles from a lower trunk plexopathy is often irreversible. Surgical decompression is recommended for LN lesions when neuropathy arises [7]; in most cases, this involves a carpal tunnel release. In this case, surgical decompression was achieved with lipoma resection.…”

Section: Discussionmentioning

confidence: 99%

A Clear Mystery: Recognizing Lipomatosis of the Nerve

Gaber

Marek

Meixensberger

et al. 2019

Cureus

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Lipomatosis of the nerve (LN) commonly presents with neurologic dysfunction due to massive fibro-fatty enlargement of the peripheral nerves. It is uniquely associated with adipose proliferation in the subcutaneous tissue and muscle in the innervated territory, along with osseous abnormalities. Herein, we present the case of a 56-year-old woman who presented with severe right ulnar distribution pain involving the medial forearm and hand (9/10 on a numerical rating scale), declining right-hand strength, movement-dependent hypoesthesias, paresthesias, and a pronounced claw deformity of the right hand with intrinsic atrophy. Electrodiagnostic studies demonstrated pronounced fibrillations, decreased voluntary activation, and minimal collateral reinnervation in the abductor digiti minimi and abductor pollicis brevis, consistent with dysfunction of the lower trunk of the right brachial plexus. Magnetic resonance imaging (MRI) and computed tomography (CT) of the brachial plexus were interpreted as a tumor on the right supra- and infraclavicular brachial plexus. At surgery, the brachial plexus was embedded in relatively tight connective tissue with a typical lipoma posteriorly. The lipoma was resected, and the plexus was explored extensively. This case is the 10th report of LN involving the brachial plexus and demonstrated the cardinal features of LN. It provides insight into the pattern of lesions associated with innervation by LN.

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Surgical Treatment of Lipomatosis of Nerve: A Systematic Review

Cited by 22 publications

References 18 publications

Lipofibromatous Hamartoma of Digital Nerve: A Case Report

Lipofibromatous Hamartoma of Digital Nerve: A Case Report

Carpal tunnel syndrome revealing a fibrolipoma of the median nerve

A Clear Mystery: Recognizing Lipomatosis of the Nerve

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