Surgical Treatment of Gastrointestinal Stromal Tumor in the Esophagus: Report of Three Cases

Fang, Fu-Chi; Tzao, Ching; Cheng, Yeung-Leung; Chan, De-Chuan; Nieh, Shin; Lee, Shih Chun

doi:10.1055/s-2007-963428

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…The most common primary sites for these neoplasms are the stomach (60-70%) [1, 6], followed by the small intestine (25-35%) [1, 6, 7], and to a much lesser degree the colon and rectum (10%) [8]. GISTs have also been observed in the mesentery, omentum, esophagus, and the peritoneum [6, 9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Clinical and molecular characteristics of gastrointestinal stromal tumors in the pediatric and young adult population

Rink¹,

Godwin

2009

Curr Oncol Rep

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Gastrointestinal stromal tumors (GISTs) typically occur late in life; however, there are also reports of these tumors in pediatric patients and young adults. This rare, but fascinating subset of GISTs, have distinct clinical-pathological and molecular deviations from their adult counterparts. The majority of pediatric GIST patients are female and often present with multi-focal tumors that are completely or partly epithelioid in nature. These young patients often have metastatic disease, but still follow a slow course of disease progression. Molecularly, most pediatric GISTs lack the gain-of-function mutations in the KIT and PDGFRA genes, which are commonly found in adult cases. Recent expression profiling and genomic studies of pediatric GISTs show distinct molecular signatures, suggesting a unique origin as compared to adult GISTs. We and others have shown that the insulin-like growth factor 1 receptor (IGF1R) may have a prominent role in driving those adult and pediatric GISTs that lack KIT and PDGFRA activating mutations and clinical trials are currently being designed to exploit these types of discoveries.

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Section: Introductionmentioning

confidence: 99%

Clinical and molecular characteristics of gastrointestinal stromal tumors in the pediatric and young adult population

Rink¹,

Godwin

2009

Curr Oncol Rep

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“…Currently, the conventional treatment of stromal tumors is primarily open surgery or laparoscopic excision [1][2][3][4][5][6][7][8][9][10]. Reports of both techniques, including, for example, en bloc removal of an extra-gastrointestinal stromal tumor (EGIST) of the greater omentum and laparoscopic intragastric approach for gastrointestinal stromal tumor (GIST) of the posterior gastric wall, show that conventional treatment can meet surgical challenges and achieve satisfactory outcomes [1,3].…”

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confidence: 99%

Full-thickness endoscopic resection of nonintracavitary gastric stromal tumors: a novel approach

et al. 2010

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“…Traditional chemotherapy is almost completely inefficient in GIST patients, and surgical resection is the best course of treatment . So far, few studies examined esophageal stromal tumors and leiomyomata, all with a number of cases less than 5 . We retrospectively analyzed 93 cases of esophageal stromal tumors and leiomyomata, including clinical symptoms, endoscopic features, pathological characteristics, IHC results, treatment, and outcomes.…”

Section: Introductionmentioning

confidence: 99%

Differential clinical and pathological characteristics of esophageal stromal tumors and leiomyomata

2013

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The objective of the study was to assess the differences in clinical and pathological characteristics between esophageal stromal tumor and leiomyoma. Data from 93 esophageal stromal tumors and leiomyomata cases were retrospectively analyzed, including clinical symptoms, endoscopic features, pathological characteristics, immunohistochemistry (IHC), and treatment. All cases underwent endoscopic ultrasonography examination before treatment. Lesions arising from the muscularis mucosa were resected by endoscopic mucosal resection or endoscopic submucosal dissection. Lesions arising from the muscularis propria were resected by surgery. All specimens were examined by IHC. Patients were followed up after endoscopic mucosal resection or endoscopic submucosal dissection. No difference was observed in clinical symptoms and endoscopic features between the two groups. Endoscopic ultrasonography demonstrated all lesions to be hypoechoic and well circumscribed. Most lesions >2 cm had heterogeneous internal ultrasound signal. In esophageal stromal tumor, 100% (29/29) were CD117-positive and DOG-1-positive; 72.4% (21/29) and 51.7% (15/29) were CD34-positive and smooth muscle actin-positive, respectively. In esophageal leiomyomata, 100% (64/64) were smooth muscle actin-positive and desmin-positive; 100% were CD117-negative and DOG-1-negative. No local recurrence was detected in followed up patients (n = 49) after an average of 1.8 years (1.0-3.0 years). IHC analyses are important for distinguishing esophageal stromal tumor from leiomyoma. Early endoscopic resection is an effective treatment option for esophageal stromal tumors >1 cm.

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Surgical Treatment of Gastrointestinal Stromal Tumor in the Esophagus: Report of Three Cases

Abstract: The patients had uneventful postoperative recoveries and were followed up regularly at 3-month intervals.

Cited by 8 publications

References 13 publications

Clinical and molecular characteristics of gastrointestinal stromal tumors in the pediatric and young adult population

Clinical and molecular characteristics of gastrointestinal stromal tumors in the pediatric and young adult population

Full-thickness endoscopic resection of nonintracavitary gastric stromal tumors: a novel approach

Differential clinical and pathological characteristics of esophageal stromal tumors and leiomyomata

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