Surgical Treatment of Distal Cholangiocarcinoma

Gorji, Leva; Beal, Eliza W.

doi:10.3390/curroncol29090524

Cited by 10 publications

(6 citation statements)

References 101 publications

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“…CCA is a common malignant tumor characterized by high morbidity, high mortality, high metastasis rates, and a poor prognosis [ 1 , 4 – 6 ]. The pathogenesis of CCA remains unclear, and an in-depth study of its molecular mechanisms will facilitate the development of new therapeutic approaches.…”

Section: Discussionmentioning

confidence: 99%

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Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway

Cheng

2023

BMC Gastroenterol

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Background Cholangiocarcinoma (CCA) is a refractory malignancy derived from bile duct epithelial cells. This study aimed to explore the role and molecular mechanisms of action of sevoflurane in CCA. Methods CCK-8 assay was used to assess the proliferation of cholangiocarcinoma cells, and flow cytometry was used to detect cholangiocarcinoma cell apoptosis. The effects of sevoflurane on TFK1 and QBC939 cell migration and invasion were investigated using a Transwell assay. Western blotting and RT-qPCR were used to assess the expression of apoptosis-related proteins and genes, and gene expression of the Wnt/β-catenin signaling pathway. Results Our study found that sevoflurane inhibited cholangiocarcinoma cell proliferation in a dose-dependent manner. In addition, sevoflurane induced cholangiocarcinoma cell apoptosis, inhibited cholangiocarcinoma cell migration and invasion, as well as the Wnt/β-catenin signaling pathway evidenced by decreased Wnt3a, β-catenin, c-Myc, and Cyclin D1 protein and mRNA expression, reduced p-GSK3β protein expression and p-GSK3β/GSK3β ratio. Further mechanistic studies revealed that Wnt/β-catenin pathway inducer SKL2001 reversed the inhibitory effect of sevoflurane on cholangiocarcinoma cells. Conclusions Sevoflurane induces apoptosis and inhibits the growth, migration, and invasion of cholangiocarcinoma cells by inhibiting the Wnt/β-catenin signaling pathway. This study not only revealed the role of sevoflurane in the development of CCA but also elucidated new therapeutic agents for CCA.

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Section: Discussionmentioning

confidence: 99%

“…Currently, the only clinical treatment is surgical removal of the tumor [ 5 ]. However, the prognosis for surgical treatment of CCA is poor, with a survival rate of 20–40% in patients who undergo surgery [ 6 ]. Currently, there is no effective treatment for CCA, and it is necessary to explore new therapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway

Cheng

2023

BMC Gastroenterol

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“…4 Surgical resection and adjuvant therapy, two rocks and one bird Surgical resection maintains a momentous tactic for pCCA and dCCA therapy while adequate assessment and preoperative consideration are necessary to be priorly executed which restricts candidates for curative-intent surgical resection therapy (36,37).…”

Section: Epidemiology and Risk Factors Past And Currentmentioning

confidence: 99%

An overview of extrahepatic cholangiocarcinoma: from here to where?

Yang

Zhang

2023

Front. Oncol.

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Extrahepatic cholangiocarcinoma (eCCA) contains perihilar cholangiocarcinoma and distal cholangiocarcinoma both of which can arise at any point of the biliary tree and originate from disparate anatomical sites. Generally, the incidence of eCCA is increasing globally. Though surgical resection is the principal treatment of choice for the early stages of eCCA, optimal survival remains restricted by the high risk of recurrence when most patients are present with unresectable disease or distant metastasis. Furthermore, both intra- and intertumoral heterogeneity make it laborious to determine molecularly targeted therapies. In this review, we mainly focused on current findings in the field of eCCA, mostly including epidemiology, genomic abnormalities, molecular pathogenesis, tumor microenvironment, and other details while a summary of the biological mechanisms driving eCCA may shed light on intricate tumorigenesis and feasible treatment strategies.

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“…Distal cholangiocarcinoma (dCCA) is a malignant neoplasm located in the last portion of the biliary tract, specifically from the junction of the cystic and hepatic ducts to the ampulla of Vater [ 1 ]. This neoplasm is an aggressive form of epithelial origin, representing approximately 30% of all cholangiocarcinomas [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Outcomes of Minimally Invasive Versus Open Pancreatoduodenectomy in Distal Cholangiocarcinoma: A Systematic Review and Meta-Analysis

Domene,

Quiroz Flores,

Fulginiti

et al. 2024

Cureus

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Pancreatoduodenectomy, the primary surgical strategy for managing cholangiocarcinoma, is executed via two distinct methodologies, namely minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD). The selection between these surgical options is critical, as it directly influences patient outcomes, encompassing both short-term recovery metrics and long-term survival rates. Despite the clinical significance of these procedures, there exists a notable void in the literature regarding a comprehensive comparison of MIPD and OPD, particularly in assessing their respective efficacies and complications. This lack of detailed comparative analysis has left a gap in evidence-based guidance for clinicians faced with the decision of choosing the most appropriate surgical approach for their patients. The absence of robust data comparing the two techniques underscores the necessity for a meta-analysis that rigorously examines and contrasts the outcomes associated with MIPD and OPD. By drawing upon a wide array of international studies, this research aims to shed light on the advantages and potential drawbacks of each method, thereby providing a more informed basis for surgical decision-making in the treatment of cholangiocarcinoma.

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Surgical Treatment of Distal Cholangiocarcinoma

Cited by 10 publications

References 101 publications

Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway

Sevoflurane inhibits cholangiocarcinoma via Wnt/β-catenin signaling pathway

An overview of extrahepatic cholangiocarcinoma: from here to where?

Comparative Outcomes of Minimally Invasive Versus Open Pancreatoduodenectomy in Distal Cholangiocarcinoma: A Systematic Review and Meta-Analysis

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