Surgical treatment of chronic aortoiliac occlusion

Lucas, Márcio Luı́s; Deibler, Lúcia; Erling, Nilon; Lichtenfels, Eduardo; Aerts, Newton

doi:10.1590/1677-5449.20140041

Cited by 4 publications

(8 citation statements)

References 22 publications

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“…Advanced AOD tends to occur in relatively young patients who have a history of tobacco abuse. Basically, patients with SAS and TAO are treated by the aortobifemoral bypass and the surgical results in these patients seems to be similar [ 2 , 19 ] .…”

Section: Discussionmentioning

confidence: 99%

“…We reviewed medical records for patients with SAS and TAO electively submitted to aortobifemoral bypass by the first author as previously described [ 2 ] .…”

Section: Methodsmentioning

confidence: 99%

“…The project was approved by the Research Ethics Committee of Santa Casa de Porto Alegre and all patients signed free and informed consent forms. We reviewed medical records for patients with SAS and TAO electively submitted to aortobifemoral bypass by the first author as previously described [ 2 ] .…”

Section: Methodsmentioning

confidence: 99%

“…Although advances in the endovascular techniques, aortobifemoral bypass is still the gold standard treatment for patients with SAS and TAO [ 1 , 2 ] .…”

Section: Introductionmentioning

confidence: 99%

“…Aortoiliac occlusive disease (AOD) provoked by atherosclerosis is an important cause of morbidity and mortality worldwide, which begins at the aortic terminus and common iliac artery origins and slowly progresses proximally and distally over time, resulting in a severe aortoiliac stenosis (SAS) or in a total aortoiliac occlusion (TAO) [ 1 ] . Although advances in the endovascular techniques, aortobifemoral bypass is still the gold standard treatment for patients with SAS and TAO [ 1 , 2 ] .…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Damage in Human Aorta of Patients with Advanced Aortoiliac Occlusive Disease

Lucas

Carraro

Belló‐Klein

et al. 2016

Brazilian Journal of Cardiovascular Surgery

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IntroductionOxidative stress seems to be a role in the atherosclerosis process, but research in human beings is scarce.ObjectiveTo evaluate the role of oxidative stress on human aortas of patients submitted to surgical treatment for advanced aortoiliac occlusive disease.MethodsTwenty-six patients were divided into three groups: control group (n=10) formed by cadaveric organ donors; severe aortoiliac stenosis group (patients with severe aortoiliac stenosis; n=9); and total aortoiliac occlusion group (patients with chronic total aortoiliac occlusion; n=7). We evaluated the reactive oxygen species concentration, nicotinamide adenine dinucleotide phosphate-oxidase, superoxide dismutase and catalase activities as well as nitrite levels in samples of aortas harvested during aortofemoral bypass for treatment of advanced aortoiliac occlusive disease.ResultsWe observed a higher level of reactive oxygen species in total aortoiliac occlusion group (48.3±9.56 pmol/mg protein) when compared to severe aortoiliac stenosis (33.5±7.4 pmol/mg protein) and control (4.91±0.8 pmol/mg protein) groups (P<0.05). Nicotinamide adenine dinucleotide phosphate oxidase activity was also higher in total aortoiliac occlusion group when compared to the control group (3.81±1.7 versus 1.05±0.31 µmol/min.mg protein; P<0.05). Furthermore, superoxide dismutase and catalase activities were significantly higher in the severe aortoiliac stenosis and total aortoiliac occlusion groups when compared to the control cases (P<0.05). Nitrite concentration was smaller in the severe aortoiliac stenosis group in comparing to the other groups.ConclusionOur results indicated an increase of reactive oxygen species levels and nicotinamide adenine dinucleotide phosphate-oxidase activity in human aortic samples of patients with advanced aortoiliac occlusive disease. The increase of antioxidant enzymes activities may be due to a compensative phenomenon to reactive oxygen species production mediated by nicotinamide adenine dinucleotide phosphate oxidase. This preliminary study offers us a more comprehensive knowledge about the role of oxidative stress in advanced aortoiliac occlusive disease in human beings.

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Section: Discussionmentioning

confidence: 99%

“…We reviewed medical records for patients with SAS and TAO electively submitted to aortobifemoral bypass by the first author as previously described [ 2 ] .…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Although advances in the endovascular techniques, aortobifemoral bypass is still the gold standard treatment for patients with SAS and TAO [ 1 , 2 ] .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oxidative Damage in Human Aorta of Patients with Advanced Aortoiliac Occlusive Disease

Lucas

Carraro

Belló‐Klein

et al. 2016

Brazilian Journal of Cardiovascular Surgery

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The role of subtraction angiography in the diagnosis of distal aorta occlusion following CT urography: A case report

Mosquera-Lopez¹,

Mosquera-Lopez²,

Cuesta-Pertuz³

2023

Radiology Case Reports

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Peculiarities of the Structural and Functional Rearrangement of the Parenchyma of the Testes of Rats With Dosed Stenosis of the Aorto-Iliac Segment

et al. 2022

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Relevance. Abdominal ischemic disease is a general term that characterizes various clinical syndromes of damage to the organs of the digestive system when blood flow is disturbed in the abdominal part of the aorta and its branches, as a result of which there is a disparity of the blood supply of internal organs to their energy needs with the subsequent development of chronic ischemia and necrosis of cells and tissue. Objective. To establish the characteristic features of the dynamics of the remodeling of the blood vessel of the testicles of rats with dosed stenosis of the aorto-iliac segment. Materials and methods. The experiment was conducted on 48 white outbred sexually mature male rats with an average age of 3 months and a weight of 180-200 g. All animals were divided into two groups: experimental group consisted of 36 animals with simulated dosage stenosis of the aorto-iliac segment and control group (12 subjects). All operative manipulations were performed in compliance with the rules of asepsis and antisepsis. Preliminary anesthetization of the animals was carried out with the intramuscular injections of ketamine (50 mg/ml) in terms of 0.083 mg/g of body weight. After performing a laparotomy through a midsection along the white line of the abdominal wall, the abdominal aorta was isolated and compressed by 1/3 of its diameter by applying a silk ligature. The degree of narrowing was controlled using a metal probe with a cone-shaped tip according to the already known method. On the 1st, 3rd, 7th, and 14th day, the animals were taken out of the experiment and an organometric assessment of the condition of the testicles was carried out with the determination of the following parameters: the weight of the organ was determined using a torsion weight VT-500, the length and width were measured using a caliper. After that, pieces of testicular tissue were taken and fixed in a 10% solution of neutral formalin and 96% ethyl alcohol. The obtained paraffin sections with a thickness of 5-7 μm were stained with hematoxylin and eosin, and microscopic examination of a series of histological sections was carried out. Results. A day after the simulation of experimental stenosis of the aorto-iliac segment, a microscopic examination of the structures of the testicle revealed significant swelling of the stroma of the organ. The interstitial tissue was unevenly located between the tortuous seminiferous tubules, the lumen between which was slightly expanded. At the same time, the internal structure of the tubules remained preserved, layers of spermatogenic cells at different stages of maturation were clearly differentiated in them. On the third day of observation, previously identified signs of disorders of organ blood circulation in the testicles continued to increase. The swelling of the testicular interstitial tissue slightly decreased, but it was accompanied by changes in the structure of the cells of the spermatogenic epithelium, the manifestation of which was the detachment of spermatogonia from the basal membrane of the tubules and the expansion of the spaces between the rows of spermatogenic cells. The walls of the small arteries and arterioles were still significantly thickened. On the 7th day of observation, against the background of a significant decrease in the swelling of the space between the tortuous seminiferous tubules, dystrophic changes in the testicular tissue began to increase. On the 14th day of observation, even more expressed signs of organ hemodynamics violation were observed, and as a result, deviations of the trophism of testicles of experimental animals. Manifestation of such changes were prominent arterial and venous plethora. Large-caliber arteries were significantly filled with blood, and as a result, small and medium-caliber arteries, especially arterioles, had thickened walls and a markedly narrowed lumen. Conclusion. With dosed stenosis of the aorto-iliac segment, significant disorders of central hemodynamics occur, which are characteristic of occlusive diseases of the aorta and its branches. As a result, in the testes of sexually mature male rats, dystrophic changes in the cells of the spermatogenic epithelium occur and the functional activity of the organ decreases, which can form the basis for the development of infertility.

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Surgical treatment of chronic aortoiliac occlusion

Cited by 4 publications

References 22 publications

Oxidative Damage in Human Aorta of Patients with Advanced Aortoiliac Occlusive Disease

Oxidative Damage in Human Aorta of Patients with Advanced Aortoiliac Occlusive Disease

The role of subtraction angiography in the diagnosis of distal aorta occlusion following CT urography: A case report

Peculiarities of the Structural and Functional Rearrangement of the Parenchyma of the Testes of Rats With Dosed Stenosis of the Aorto-Iliac Segment

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