Sarcopenia is the loss of skeletal muscle mass, strength and quality [ 1 ] in unison with biological ageing [ 2 ]. Sarcopenia is common in adults over the age of 45 years and increases with age [ 3 ]. There is a reduction of muscle mass and strength in all elderly people. Muscle mass and strength reach a maximum in the second and third decade and gradually decline in middle age, and around the age of 80, the loss of muscle accelerates leading to progressive weakness [ 4 ]. By the age of 75, the muscle mass is halved and the adipose tissue doubled compared to that of a young adult. The rate and extent to which muscle changes occur are to some extent genetically determined.The cause of sarcopenia is multifactorial [ 2 , 5 ]. Several factors contribute and these include loss of neurons due to central nervous system decline, loss of muscle contractile function, humoral factors (growth hormone, testosterone and oestrogen are reduced with age), increase in catabolic mediators produced by the immune system [ 5 ] and reduced rate of skeletal muscle protein synthesis [ 2 ]. Other factors that are related to muscle loss in the elderly are reduced levels of physical activity [ 2 , 6 ], increased rates of immobilisation [ 7 ] and deconditioning disease.If sarcopenia progresses beyond a certain threshold of functional requirements, it leads to disability and frailty. It is found in 20-30 % of elderly over the age of 70 years and increases with advancing age [ 8 ]. According to Lang et al. [ 9 ], in frailty there is no single symptom crucial in its presentation, but rather it is clearly recognised by clinicians with its multiple manifestations, appearance, nutritional status, performance and health rates, among others. There is no way of knowing at what level of lean mass, sarcopenia is present. The New Mexico Health Survey measured appendicular muscle mass by dual energy X-ray absorptiometry (DEXA) in 883 Hispanic and non-Hispanic white men and women and defi ned sarcopenia as a muscle mass of two or more standard deviations below the mean for young healthy participants [ 10 ]. There is however a direct structure-function relationship between muscle loss and strength [ 6 ].
Answers to MCQs1 = C; 2 = C. References Anatomical and Physiological Changes with Aging -Musculoskeletal System 1. Dutta C. Signifi cance of sarcopenia in the elderly. J Nutr. 1997;127:992S-3. 2. Doherty TJ. Invited review. Aging and sarcopenia. J Appl Physiol. 2003;95(4):1717-24 (abstract).