Surgical treatment of adult primary hepatic sarcoma

Poggio, Juan Lucas; Nagorney, David M.; Nascimento, Antonio G.; Rowland, Charles; Kay, Paul; Young, Richard M.; Donohue, John H.

doi:10.1046/j.1365-2168.2000.01564.x

Cited by 45 publications

(54 citation statements)

References 21 publications

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“…While surgery is mostly applied in different situations, multimodality approaches have been attempted including chemotherapy, transplantation,radiotherapy,andlocalembolization,among others. Multivariate analysis showed that smaller tumor size andnegativeresectionmarginwereassociatedwithimproved survival,whichisconsistentwithotherstudies [8,9].…”

Section: Discussionsupporting

confidence: 65%

“…Early local or distant relapse is themainproblematicissueforOLTandhasbeendescribed by Husted et al [4] in 6 primary hepatic angiosarcoma patientsandbyPoggioetal. [8]in5primaryhepaticLMSpa-tients. Nevertheless, Rajput et al [23] found that significant reductionofimmunosuppressionmayhelpcontaintumordevelopmentandprolongOSdespitetumorrecurrence,which wasfurthersupportedbyBrichardetal.…”

Section: Tumor Size and Metastasismentioning

confidence: 99%

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Primary Hepatic Leiomyosarcoma in Adults: Analysis of Prognostic Factors

2012

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Primary hepatic leiomyosarcoma (LMS) is a rare malignancy of the liver in adults, with variable overall survival (OS). The main purpose of this study was to identify prognostic factors of improved survival. Relevant data were abstracted from MEDLINE, EMBASE, and Academic Search Premiere (ASP), and from the medical records of a patient treated at our institution. Multivariate analysis was conducted by generating Cox proportional hazard ratios. We identified 109 patients with primary hepatic LMS; 95 were included for basic description, and 84 for OS analysis. Median age was 58 years (range 19–86 years), 45.0% of the patients were female, and 21.1% were AJCC stage IV. The primary treatment for all 95 patients was as follows: 61.1% had surgery, 13.7% had chemotherapy, 5.3% had liver transplantation, 2.1% received radiotherapy, and 14.7% were managed conservatively. Median OS was 19 months (range 0–181 months) with 1-, 2-, and 5-year survival rates of 61.2, 41.1, and 14.5%, respectively. In a multivariate analysis, smaller size of the largest hepatic lesion (p = 0.038) and negative resection margin (p = 0.0004) were associated with improved survival. Complete surgical resection with clear margin is necessary to improve survival of patients with primary hepatic LMS.

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Section: Discussionsupporting

confidence: 65%

Section: Tumor Size and Metastasismentioning

confidence: 99%

Primary Hepatic Leiomyosarcoma in Adults: Analysis of Prognostic Factors

2012

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“…4,6,18,19 Liver surgery has improved and new tech- niques of resection and a wider understanding of the perioperative treatment are constantly reducing the perioperative morbidity and mortality. Today, wherever feasible, a malignant tumor of the liver should be resected.…”

Section: P=40) or Tumor Grading (G1ϩg2 Vs G3 P=65)mentioning

confidence: 99%

Long-term Survival After Surgery for Primary Hepatic Sarcoma in Adults

Matthaei

Krieg²,

Schmelzle³

et al. 2009

Arch Surg

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“…When the diagnosis is made ante-mortem, PHAs are usually identified at an advanced stage, when therapeutic options are limited (4,12,13). In our case, the diagnosis was made relatively early in the absence of metastatic or locally advanced disease.…”

Section: Discussionmentioning

confidence: 99%

Herald bleeding from a ruptured primary hepatic angiosarcoma: A case report

Cawich

Ramjit

2015

Molecular and Clinical Oncology

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Abstract. Primary hepatic angiosarcomas (PHAs) are rare tumours with an estimated annual incidence of 0.05 per million in the Caribbean, which is similar to that reported in Western countries. Although a number of cases are detected post-mortem, the most common clinical presentation is with tumour rupture and herald bleeding. This is the case report of a 60-year old female patient who presented with vague upper abdominal pain, found via imaging examinations to be due to a ruptured hepatic tumour in segment III of the liver. The tumour was removed via laparoscopic left lateral sectionectomy, with clear resection margins. The histopathological and immunohistochemical examination established the diagnosis of PHA. Therefore, an index of suspicion should be maintained in selected patients and, when detected ante-mortem, PHAs should be treated aggressively with complete surgical resection to achieve microscopically clear margins, as the response of these tumours to other forms of adjuvant therapy may be unpredictable.

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Surgical treatment of adult primary hepatic sarcoma

Abstract: Surgical resection is the only effective therapy for primary hepatic sarcomas at present. Better adjuvant therapy is necessary, especially for high-grade malignancies, owing to the high failure rate with operation alone.

Cited by 45 publications

References 21 publications

Primary Hepatic Leiomyosarcoma in Adults: Analysis of Prognostic Factors

Primary Hepatic Leiomyosarcoma in Adults: Analysis of Prognostic Factors

Long-term Survival After Surgery for Primary Hepatic Sarcoma in Adults

Herald bleeding from a ruptured primary hepatic angiosarcoma: A case report

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