“…The use of sutureless self-retained cryopreserved AM allows early intervention as it can be performed in the office not only to facilitate the treatment but also to reduce the overall cost. Previously, a number of reports have shown the effectiveness of single 15 , 16 , 18 – 22 , 26 , 27 , 29 , 32 or multiple 15 – 18 , 20 – 28 , 30 , 31 , 33 layers of sutured AM for infectious 5 , 6 , 15 – 23 , 25 , 27 , 28 , 33 or non-infectious 15 , 17 , 18 , 21 – 26 , 28 – 32 corneal ulcers and several reports have similarly shown the effectiveness of sutureless AM for infectious 7 – 10 and non-infectious 7 , 12 – 14 corneal ulcers. The three retrospective case series 7 – 10 that evaluated self-retained AM for infectious corneal ulcers showed healing in 66–100% of cases in as little as 4 days along with reduced ocular surface inflammation and improved VA during 3–51 months of follow-up.…”