Surgical treatment for primary lung cancer combined with idiopathic pulmonary fibrosis

Watanabe, Atsushi; Miyajima, Masayoshi; Mishina, Taijiro; Nakazawa, Junji; Harada, Ryo; Kawaharada, Nobuyoshi; Higami, Tetsuya

doi:10.1007/s11748-012-0180-6

Cited by 44 publications

(29 citation statements)

References 57 publications

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“…IPF is associated with an increased risk of lung cancer, with a relative risk of 7.0-14.0 (compared with the general population) (7). Approximately 2% to 4% of lung cancer patients have IPF (2).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical results of sublobar resection versus lobectomy or more extensive resection for lung cancer patients with idiopathic pulmonary fibrosis

Joo¹,

Kim²,

Sim³

et al. 2016

J. Thorac. Dis.

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Section: Discussionmentioning

confidence: 99%

“…IPF is associated with an increased risk of lung cancer. The prevalence of lung cancer in patients with IPF is high, ranging from 4.8% to 48% (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Clinical results of sublobar resection versus lobectomy or more extensive resection for lung cancer patients with idiopathic pulmonary fibrosis

Joo¹,

Kim²,

Sim³

et al. 2016

J. Thorac. Dis.

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“…Patients with IPF have shown markedly higher rates of postoperative pulmonary morbidity (26%) and mortality (8%) after surgical resection for lung cancer as compared to those without IPF [8,9]. Several studies have shown that other types of ILD also influence PPCs and mortality after lung surgery [10], and the patients with ILD had a higher incidence of these complications compared to those without ILD after lung resection.…”

Section: Introductionmentioning

confidence: 99%

Postoperative Pulmonary Complications after Surgery in Patients with Interstitial Lung Disease

et al. 2014

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Background: Patients with interstitial lung disease (ILD) have a high incidence of postoperative pulmonary complications (PPCs) after lung resection, but there is little data about these complications in ILD after other types of surgery. Objectives: The aim of this study was to examine the characteristics and predictors of PPCs after major surgery in patients with ILD. Methods: We included 336 patients with ILD who underwent major surgery between January 2005 and December 2010 at two tertiary hospitals in Korea. All types of surgery that had been performed under general anesthesia were included. Demographic characteristics, preoperative lung function, and operative conditions including anesthesia time and estimated blood loss were compared between patients with and without PPCs. Results: PPCs occurred in 37 patients (11%). Thirteen patients developed pneumonia, the most common PPC, and 11 had acute exacerbation of ILD. In multivariable analysis, BMI <23 (OR = 2.488, 95% CI: 1.084-5.710, p = 0.031), emergency surgery (OR = 23.992, 95% CI: 2.629-218.949, p = 0.005), lung surgery (OR = 5.090, 95% CI: 1.391-18.628, p = 0.014), and longer anesthesia time (OR = 1.595, 95% CI: 1.143-2.227, p = 0.006) were statistically significant risk factors. Conclusions: The incidence of PPCs detected over all surgeries was not as high as that reported for lung surgery alone in ILD patients. Lower BMI, emergency surgery, lung surgery, and longer anesthesia time were risk factors. Operative conditions as well as lung function should be considered in preoperative planning and management for ILD patients undergoing major surgery.

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“…Interstitial pneumonia and emphysema provoke more risks for postoperative complications and mortality. [10,18–22] Here, we identified a predictive factor for postoperative mortality in patients with NSCLC and CPFE in a multiinstitutional setting.…”

Section: Discussionmentioning

confidence: 99%

“…These rates were also higher than previous postoperative 30-day mortality and complication rates for NSCLC in Japan (0%–0.9% and about 20%, respectively). [18,20,22–25] . Hence, modalities for treating NSCLC in patients with CPFE should be carefully determined.…”

Section: Discussionmentioning

confidence: 99%

Severity of lung fibrosis affects early surgical outcomes of lung cancer among patients with combined pulmonary fibrosis and emphysema

Mimae

Suzuki²,

Tsuboi

et al. 2016

Medicine

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Combined pulmonary fibrosis and emphysema (CPFE) is defined as upper lobe emphysema and lower lobe fibrosis, which are representative lung disorders that increase the prevalence of lung cancer. This unique disorder may affect the morbidity and mortality during the early period after surgery. The present study aimed to identify which clinicopathological features significantly affect early surgical outcomes after lung resection in nonsmall cell lung cancer (NSCLC) patients and in those with CPFE.We retrospectively assessed 2295 patients with NSCLC and found that 151 (6.6%) had CPFE. All were surgically treated between January 2008 and December 2010 at 4 institutions.The postoperative complication rates for patients with and without CPFE were 39% and 17%, respectively. The 90-day mortality rates were higher among patients with than without CPFE (7.9% vs 1%). Acute exacerbation of interstitial pneumonia was the main cause of death among 12 patients with CPFE who died within 90 days after surgery. Multivariate logistic regression analysis selected CPFE, gender, age, and clinical stage as independent predictive factors for postoperative complications, and CPFE, clinical stage, and sex for 90-day mortality. The severity of lung fibrosis on preoperative CT images was an independent predictive factor for 90-day mortality among patients with CPFE.The key predictive factor for postoperative mortality and complications of lung resection for NSCLC was CPFE. The severity of lung fibrosis was the principal predictor of early outcomes after lung surgery among patients with CPFE and NSCLC.

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Surgical treatment for primary lung cancer combined with idiopathic pulmonary fibrosis

Cited by 44 publications

References 57 publications

Clinical results of sublobar resection versus lobectomy or more extensive resection for lung cancer patients with idiopathic pulmonary fibrosis

Clinical results of sublobar resection versus lobectomy or more extensive resection for lung cancer patients with idiopathic pulmonary fibrosis

Postoperative Pulmonary Complications after Surgery in Patients with Interstitial Lung Disease

Severity of lung fibrosis affects early surgical outcomes of lung cancer among patients with combined pulmonary fibrosis and emphysema

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