Surgical Treatment for Liver Cancer

Miyazaki, Masaru; Kimura, Fumio; Shimizu, Hiroaki; Yoshidome, Hiroyuki; Ohtsuka, Masayuki; Kato, Atushi; Yoshitomi, Hideyuki; Nozawa, Satoshi; Furukawa, Katsunori; Takeuchi, Dan; Suda, Kosuke; Yoshioka, Isaku; Mituhashi, Noboru

doi:10.1159/000101899

Cited by 12 publications

(6 citation statements)

References 73 publications

(39 reference statements)

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“…In the clinical practice, hepatectomy is the most effective method for the radical cure of primary malignant hepatobiliary tumors. 28,29 Before hepatectomy, evaluating liver functional reserve is needed to avoid postoperative liver failure. Previous studies have shown that the liver elasticity values measured using Virtual Touch Quantification were moderately to strongly correlated with liver functional reserve, using the indocyanine green excretion test and technetium-99m-diethylenetria-minepentaacetic acid-galactosyl-human serum albumin scintigraphy.…”

Section: Discussionmentioning

confidence: 99%

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Significance of Shear Wave Dispersion Slope Values Before Versus After Biliary Drainage in Patients With Obstructive Jaundice

Sugiura

Kuwatani²,

Nishida

et al. 2023

Ultrasound Quarterly

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The shear wave dispersion (SWD) slope has become available in the clinical practice and is related to tissue viscosity. However, clinical evaluation using SWD was not yet performed for obstructive jaundice. We aimed to evaluate the change of SWD values between before and after biliary drainage in patients with obstructive jaundice. This prospective observational cohort study evaluated 20 patients with obstructive jaundice who underwent biliary drainage. The SWD and liver elasticity values were measured before versus after biliary drainage, comparing between days −5 and 0 (day 0), days 1 and 3 (day 2), and days 6 and 8 (day 7). The mean ± SD values of SWD measured at day 0, day 2, and day 7 were 15.3 ± 2.7, 14.2 ± 3.3, and 13.3 ± 2.4 m/s/kHz, respectively. Dispersion slope values were decreased significantly from day 0 to day 2, from day 2 to day 7, and from day 0 to day 7 ( P < 0.05). Liver elasticity levels and serum hepatobiliary enzymes were additionally decreased significantly over time after biliary drainage. The correlations between SWD and liver elasticity values were strong (r = 0.91, P < 0.01). In conclusion, the SWD values decreased significantly over time after biliary drainage concomitant with liver elasticity.

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Section: Discussionmentioning

confidence: 99%

“…In the clinical practice, hepatectomy is the most effective method for the radical cure of primary malignant hepatobiliary tumors 28,29 . Before hepatectomy, evaluating liver functional reserve is needed to avoid postoperative liver failure.…”

Section: Discussionmentioning

confidence: 99%

Significance of Shear Wave Dispersion Slope Values Before Versus After Biliary Drainage in Patients With Obstructive Jaundice

Sugiura

Kuwatani²,

Nishida

et al. 2023

Ultrasound Quarterly

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“…Bile duct cancer (BDC) and hepatocellular carcinoma (HCC) are the most common malignant tumors of the hepatobiliary system. Hepatectomy is the most effective method for the radical cure of hilar BDC (HBDC), intrahepatic BDC (IHBDC), and HCC (Nimura et al 1998;Miyazaki et al 2007), however, excessive hepatectomy has a high risk of liver failure in BDC and HCC patients (Breitenstein et al 2010;Lock et al 2009). To reduce post-hepatectomy morbidity and mortality, preoperative assessment of liver functional reserve is important (Mizumoto et al 1979).…”

Section: Introductionmentioning

confidence: 99%

Correlation between Liver Elasticity by Ultrasound Elastography and Liver Functional Reserve

Sugiura

Kuwatani

Nishida

et al. 2019

Ultrasound in Medicine & Biology

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No worldwide consensus on the assessment tool for liver functional reserve is currently available. The aim of this study was to evaluate correlation between liver elasticity of both hepatic lobes and liver functional reserve tests. This prospective observational study comprised 40 patients scheduled for hepatectomy. Liver elasticity was assessed by Virtual Touch TM Quantification (VTQ). The mean VTQ value for the right and left lobes was defined as the mVTQ. Liver functional reserve was measured by technetium-99 mdiethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99 mTc-GSA) scintigraphy as LHL15 and HH15, and indocyanine green (ICG) excretion test as ICG-R15 and ICG-K. All examinations were measured after biliary decompression confirmed serum total bilirubin level ≤2mg/dL. mVTQ values were moderately correlated with LHL15 (r=−0.42, P<0.01), HH15 (r=0.48, P<0.01), ICG-R15 values (r=0.53, P<0.01), and ICG-K (r=−0.61, P<0.01). In conclusion, the liver elasticity by VTQ would be a useful predictor for liver functional reserve in patients scheduled for hepatectomy.

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“…Even after liver resection, overall prognosis is poor [ 22 – 24 ]. 1-year survival rates after surgical resection are 80-90 %, falling to 41-74 % at 5 years [ 12 , 25 , 26 ]. Unfortunately less than 20 % of patients are surgical candidates because of advanced disease stage at presentation.…”

Section: Introductionmentioning

confidence: 99%

Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma

et al. 2015

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BackgroundDespite advances in therapeutics, outcomes for hepatocellular carcinoma (HCC) remain poor and there is an urgent need for efficacious systemic therapy. Unfortunately, drugs that are successful in preclinical studies often fail in the clinical setting, and we hypothesize that this is due to functional differences between primary tumors and commonly used preclinical models. In this study, we attempt to answer this question by comparing tumor morphology and gene expression profiles between primary tumors, xenografts and HCC cell lines.MethodsHep G2 cell lines and tumor cells from patient tumor explants were subcutaneously (ectopically) injected into the flank and orthotopically into liver parenchyma of Mus Musculus SCID mice. The mice were euthanized after two weeks. RNA was extracted from the tumors, and gene expression profiling was performed using the Gene Chip Human Genome U133 Plus 2.0. Principal component analyses (PCA) and construction of dendrograms were conducted using Partek genomics suite.ResultsPCA showed that the commonly used HepG2 cell line model and its xenograft counterparts were vastly different from all fresh primary tumors. Expression profiles of primary tumors were also significantly divergent from their counterpart patient-derived xenograft (PDX) models, regardless of the site of implantation. Xenografts from the same primary tumors were more likely to cluster together regardless of site of implantation, although heat maps showed distinct differences in gene expression profiles between orthotopic and ectopic models.ConclusionsThe data presented here challenges the utility of routinely used preclinical models. Models using HepG2 were vastly different from primary tumors and PDXs, suggesting that this is not clinically representative. Surprisingly, site of implantation (orthotopic versus ectopic) resulted in limited impact on gene expression profiles, and in both scenarios xenografts differed significantly from the original primary tumors, challenging the long-held notion that orthotopic PDX model is the gold standard preclinical model for HCC.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-015-1814-8) contains supplementary material, which is available to authorized users.

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Surgical Treatment for Liver Cancer

Cited by 12 publications

References 73 publications

Significance of Shear Wave Dispersion Slope Values Before Versus After Biliary Drainage in Patients With Obstructive Jaundice

Significance of Shear Wave Dispersion Slope Values Before Versus After Biliary Drainage in Patients With Obstructive Jaundice

Correlation between Liver Elasticity by Ultrasound Elastography and Liver Functional Reserve

Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma

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