Surgical Treatment for Functional Mitral Regurgitation

Komeda, Masashi; Kitamura, Hideki; Fukaya, Shunsuke; Okawa, Yasuhide

doi:10.1253/circj.cj-09-0203

Cited by 10 publications

(6 citation statements)

References 57 publications

(59 reference statements)

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“…34 Therefore, the efficacy of surgical intervention for FMR has not been established. 35,36 Recently, percutaneous techniques for edge-to-edge repair have been developed. MitraClip ® is one of the most advanced mitral repair devices, and has started to be utilized for moderate/severe FMR.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Functional Mitral Regurgitation in Patients Admitted With Acute Decompensated Heart Failure

Wada

Ohara

Funada

et al. 2016

Circ J

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Background: Functional mitral regurgitation (FMR) is a common complication of heart failure (HF) and worsens in acute decompensation. It is unclear whether FMR on admission or discharge determines the outcome. This study aimed to elucidate the prognostic significance of FMR on admission or discharge in patients admitted with acute decompensated HF. Methods and Results:From 2006 to 2009, 349 patients admitted with acute decompensated HF were enrolled. They were followed with the composite endpoint of all-cause death and hospitalization for HF; 74 (21%) died and 113 (32%) developed the composite endpoint during 2.1±1.3 years. Moderate/severe FMR at discharge was associated with the composite endpoint (P=0.001), whereas that on admission was not. Multivariate Cox proportional hazard analysis showed that moderate/severe FMR (hazard ratio [95% confidence interval] =1.70 [1.03-2.73] P=0.04), logBNP, and NYHA class III/IV at discharge were independent determinants of the outcome. Moderate/ severe FMR at discharge with BNP ≥200 pg/ml was prognostic, but BNP <200 pg/ml was no longer prognostic. Conclusions:Residual moderate/severe FMR after medical therapy for acute decompensated HF was associated with poor outcome, suggesting a potential target for further treatment of HF. (Circ J 2016; 80: 139 -147)

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Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Functional Mitral Regurgitation in Patients Admitted With Acute Decompensated Heart Failure

Wada

Ohara

Funada

et al. 2016

Circ J

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“…Even today, we have no reliable predictors of recurrent and persistent mitral regurgitation. However, the surgical treatment of IMR continues to evolve and new methods addressing ventricular structures are being introduced: left ventricular restoration, PMs relocation, sling, imbrication or reapproximation, chordal cutting or translocation 1 . Despite remarkable progress in reparative surgery, further investigation is necessary to finding the best approach to treating IMR.…”

Section: Resultsmentioning

confidence: 99%

“…In reality, FMR is a ventricular disease with the phenotype of a valvular disease 1 . It can be divided into 2 groups: ischemic and non-ischemic.…”

Section: Introductionmentioning

confidence: 99%

“…This combined procedure is usually effective 6 , however, there is a high rate of recurrence (∼30%) of mitral regurgitation 1 , even in patients with good early postoperative results 7,8 . This poor long-term outcome suggests the need for a complex approach to treating ischemic mitral regurgitation which addresses not only the annular, but particularly the ventricular component of mitral regurgitation 1 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Persistent and Recurrent Ischemic Mitral Regurgitation

Troubil¹,

Lonský²,

Gwozdziewicz³

et al. 2010

BIOMED PAP

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“…Because the mitral regurgitation was not functional but valvular, mitral valve replacement was needed. 5 Although uncommon, congenital membranes can present in adult life with clinical and echocardiographic features suggestive of aortic stenosis. Careful echocardiographic assessment should always be undertaken to confirm the precise diagnosis.…”

Section: Images In Cardiovascular Medicine Membranous-type Svasmentioning

confidence: 99%