Surgical treatment and reconstruction for central giant cell granuloma of the jaws: A review of 18 cases

Tosco, Paolo; Tanteri, Giulia; Iaquinta, Caterina; Fasolis, Massimo; Roccia, Fabio; Berrone, Sid; Garzino-Demo, Paolo

doi:10.1016/j.jcms.2009.04.002

Cited by 54 publications

(72 citation statements)

References 38 publications

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“…1,4,11,12 Although it can be found in all age groups, most cases appear before the age of 30 years. 1,4,11 The mandible is more often involved than the maxilla 1 with a mandibular/maxillary ratio of 2:1.…”

mentioning

confidence: 99%

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Nogueira

Faria

Osterne

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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mentioning

confidence: 99%

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Nogueira

Faria

Osterne

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…Therefore, both the destructive properties of the lesion and its aggressive management can result in significant functional and esthetic defects, what is particularly a concern in pediatric and young adult patients (12,13). In the last years, different nonsurgical treatments have been proposed.…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Cytology and Intralesional Steroid Injection in a Central Giant Cell Granuloma Affecting the Gingiva: A New Clinical Approach

et al. 2013

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Central giant cell granuloma (CGCG) is a benign jaw lesion predominantly found in the mandible of young female patients with a variable clinical behavior. Although surgical management is regarded as the main treatment modality for this lesion, the use of intralesional injections of steroids has been recently advocated for its treatment. In addition to this conservative management, the use of fine needle aspiration cytology (FNAC) for diagnosing CGCGs has been proven a safe and efficient approach, especially useful in cases with lesions located in esthetic regions. Herein, it is described a case of CGCG extending to the overlying gingiva of a 15-year-old male patient diagnosed by FNAC and subsequently treated with intralesional injections of a solution of triamcinolone acetonide and ethanolamine oleate that led to an important clinical remission, allowing a more conservative surgical procedure for preservation of gingival esthetics. Therefore, both procedures can be considered as management options for CGCG of the jaws.

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“…CGCL is an uncommon benign jaw lesion, with uncertain etiology, and a variable clinical behavior (de Lange and van den Akker 2005; Kruse-Losler et al 2006;Rawashdeh et al 2006;Tosco et al 2009). Asymptomatic, slow growing lesions, may be treated by simple curettage; aggressive, fast-growing, painful lesions, may lead to root resorption and perforation of cortical bone, are usually treated by aggressive en bloc resection (Chuong et al 1986;Rawashdeh et al 2006;Tosco et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Asymptomatic, slow growing lesions, may be treated by simple curettage; aggressive, fast-growing, painful lesions, may lead to root resorption and perforation of cortical bone, are usually treated by aggressive en bloc resection (Chuong et al 1986;Rawashdeh et al 2006;Tosco et al 2009). Studies of molecular markers of CGCL, may help understanding better the nature and behaviors of this lesion, and eventually may represent a definitive target to pharmacological approach in the treatment of CGCL.…”

Section: Discussionmentioning

confidence: 99%

“…Central Giant Cell Lesion (CGCL) is an uncommon intraosseous giant cell-rich lesion located in jaws and occurs more frequently in females before the age of 30 (de Lange and van den Akker 2005; Kruse-Losler et al 2006;Rawashdeh et al 2006;Tosco et al 2009). This lesion is characterized by the presence of few-to-many multinucleated giant cells (MGC) in a cellular background composed of mononucleated stromal cells (MSC) with ovoid to spindle-shaped nuclei (Barnes et al 2005;Itonaga et al 2003;Kruse-Losler et al 2006;Nogueira et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Cyclooxygenase-2 expression in central giant cell lesion of the jaws: an immunohistochemical study

et al. 2011

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Central Giant Cell Lesion (CGCL) is an uncommon benign jaw lesion, with uncertain etiology, and a variable clinical behavior. Studies of molecular markers of CGCL, may help understanding better the nature and behavior of this lesion, and eventually may represent a definitive target to pharmacological approach in the treatment of CGCL. Chronic inflammation has been found to mediate a wide variety of diseases including neoplasms. Among the gene products involved in the induction of the inflammatory process, Cyclooxygenase 2 (COX-2) has been shown to have a close relationship with tumorigenesis, however COX-2 expression has never been evaluated in CGCL. The aim of the study was to investigate the expression of COX-2 in CGCL. Immunohistochemical assessment for COX-2 expression was performed in 18 patients previously diagnosed with CGCL. Multinucleated giant cells (MGC) and mononucleated stromal cells (MSC) were used in the slide analysis. Among the patients studied, 10 were male and 8 were female, with a median age of 15.4 years. Lesions in the mandible were observed in 11 cases and 7 were found in the maxilla. There were 9 aggressive and 9 non-aggressive CGCLs. COX-2 immunopositivity was present in only 3 cases stained in both MGC and MSC. All 3 cases presented with ulcerations in the mucosa lesion, suggesting that the COX-2 expression is due to the presence of inflammation. This study does not support the involvement of COX-2 in the etiophatogenesis of CGCL.

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Surgical treatment and reconstruction for central giant cell granuloma of the jaws: A review of 18 cases

Cited by 54 publications

References 38 publications

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Fine Needle Aspiration Cytology and Intralesional Steroid Injection in a Central Giant Cell Granuloma Affecting the Gingiva: A New Clinical Approach

Cyclooxygenase-2 expression in central giant cell lesion of the jaws: an immunohistochemical study

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