Surgical Techniques and Associated Outcomes of Primary Chondrosarcoma of the Spine

Nisson, Peyton L.; Berger, Garrett K.; James, Whitney S.; Hurlbert, R. John

doi:10.1016/j.wneu.2018.06.189

Cited by 14 publications

(27 citation statements)

References 61 publications

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“…The results showed a better prognosis in general following en bloc surgery, a nding which was compatible with those of previous studies. 4,6−8 Nearly half of the patients in the en bloc surgery group received a two-stage surgery (43.7%), including the patient in our case. Patients with multiple segment disease were inclined to receive two-stage approaches (75%, 3 of 4 patients).…”

Section: Literature Review and Analysismentioning

confidence: 79%

“…2 Up to 60% of spinal CSs occur over the thoracic spine, with the remaining incidences variously occurring over the cervical spine, lumbar spine, and sacrum. 3,4 The most common symptom is back pain, along with neurological signs related to spinal cord or nerve root compression. 3 A palpable mass has also been mentioned to occur in cases of outward extended spinal CS.…”

Section: Introductionmentioning

confidence: 99%

“…1,9 Since spinal CS is resistant to chemotherapy and conventional radiation therapy, adjuvant radiation therapy is used for any residual tumor after incomplete resection, and has been found to improve the prognosis of metastatic patients. 1,4 The overall survival rate varies across different histological gradings. The 10-year survival rates are 90% and 30 ~ 40% for Grade I CS and high-grade CS, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Primary Osseous Chondrosarcoma in the Lumbar Spine: Case Report and Literature Review With Analysis

Chiu²,

et al. 2021

Preprint

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Background Primary spinal chondrosarcoma (CS) is relatively rare, with a reported prevalence rate of less than 10% of all CS. En bloc surgery and resection without entering the tumor capsule typically provides a better prognosis. However, the approaches to such tumor lesions vary. Here, we present a case of CS in the lumbar spine treated with two-stage (anterior and posterior approach) en bloc surgery, along with an analysis and comparison of the characteristics and prognosis of one-stage versus two-stage surgery patients in previous studies. Case description A 30-year-old male with an L3 vertebral body CS presented with back pain and lower limb weakness. Lumbar spine MRI showed an L3 vertebral body tumor with cord and root compression. A two-stage surgery including posterior total laminectomy, transpedicular screw fixation over L2-L4 first with subsequent anterior corpectomy, cage implantation, and anterior lumbar interbody fusion was performed to achieve total tumor removal and stabilization. Pathology revealed a low grade CS with free resection margin. The patient’s symptoms improved after the operation, and no recurrence had occurred as of the two-year follow-up. Furthermore, we also analyzed the post-operative outcomes of 24 cases from previous publications and our current case. Conclusions Two-stage en bloc surgery concomitantly achieves total resection of the tumor, the preservation of neurological function, and a gain in stabilization. The analysis of cases showed that two-stage surgery, in comparison with one-stage surgery, seems to be beneficial in treating L-spine multiple segment disease, providing a lower rate of recurrence.

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Section: Literature Review and Analysismentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary Osseous Chondrosarcoma in the Lumbar Spine: Case Report and Literature Review With Analysis

Chiu²,

et al. 2021

Preprint

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“…Chondrosarcoma is one of most common primary malignant bone tumor with local invasiveness, potential of recurrence, and high mortality, which usually occurs in patients between 30 and 70 years of age [1][2][3] . Chondrosarcoma consists of a family of malignant tumors in which the cells tend to differentiate into cartilage, classi ed as conventional, mesenchymal, dedifferentiated, clear cell and so on [4,5] .…”

Section: Introductionmentioning

confidence: 99%

“…Kawahara N et al have reported that total excision (total en bloc spondylectomy and total piecemeal spondylectomy) including wide tumor margin was bene cial for local control and overall survival of patients with RSC [12] . Moreover, Nisson PL et al have revealed that surgical technique that entering the tumor capsule showed a signi cantly great risk for recurrence [2] . However, all these reports contained a relatively small sample size, lacking of statistical signi cance.…”

Section: Introductionmentioning

confidence: 99%

Clinical Feature and Prognostic Factors for Repeatedly Recurrent Spinal Chondrosarcoma: A Retrospective Study of 49 Patients in One Single Institution.

Zhang¹,

Xu²,

Miao³

et al. 2021

Preprint

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Background: To investigate the clinical feature in prognostic prediction of repeatedly recurrent spinal chondrosarcoma (RRSC). The purpose of this study was to illustrate the clinical parameters of RRSC and to discuss the prognostic factors by statistical analysis.Methods: Univariate and multivariate analyses were performed to investigate independent prognostic factors for recurrence and death of patients with RRSC. Recurrence-free survival (RFS) and overall survival (OS) were estimated by Kaplan-Meier curve, and differences were analyzed by log-rank test. Factors with P < 0.1 extracted by univariate analysis were subjected to multivariate analysis by Cox regression analysis. P < 0.05 were considered statistically significant.Results: Included in this study were 49 patients with RRSC who were followed up by a mean of 31.7 months (median, 25 months; range, 5-93 months). Local recurrence was detected in 33 patients, with death in 28 patients. The final statistical analysis indicated that wide surgical margin (> 4 mm) was the most favorable prognostic factor for both recurrence-free survival (RFS) and overall survival (OS). Meanwhile, fewer number of recurrences (NOR) was in favor of RFS, and lower pathological grade was a significant favorable prognostic factor for OS.Conclusion: Wide surgical margin should be considered in predicting the prognosis of RRSC, including RFS as well as OS. NOR was significant prognostic indicator for RFS, and pathological grading was significantly associated with OS.

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Gross total resection of spinal chondrosarcoma is associated with improved locoregional relapse-free survival and overall survival

et al. 2023

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Surgical Techniques and Associated Outcomes of Primary Chondrosarcoma of the Spine

Cited by 14 publications

References 61 publications

Primary Osseous Chondrosarcoma in the Lumbar Spine: Case Report and Literature Review With Analysis

Primary Osseous Chondrosarcoma in the Lumbar Spine: Case Report and Literature Review With Analysis

Clinical Feature and Prognostic Factors for Repeatedly Recurrent Spinal Chondrosarcoma: A Retrospective Study of 49 Patients in One Single Institution.

Gross total resection of spinal chondrosarcoma is associated with improved locoregional relapse-free survival and overall survival

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