Surgical Technique and Other Protocols Used Probably Did Not Induce Polyethylene Glycol Fusion of Rat Facial Nerves

Bittner, George D.; Ghergherehchi, Cameron L.; Mikesh, Michelle

doi:10.1001/jamafacial.2018.1126

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…[3] However, recent studies have not been positive, and Bittner pushed back against the methodology and conclusions of these authors. [2] In our recent study, we applied PEG 600 (0.5 mL) in a model of sciatic nerve transection without following the more convoluted Bittner’s protocol and found that PEG is effective, especially if injected inside an arterial chamber inside of which the two severed stumps are inserted. [18]…”

Section: Peripheral Nerve Fusionmentioning

confidence: 99%

Advancing the technology for head transplants: From immunology to peripheral nerve fusion

Canavero¹,

Ren²

2019

Surgical Neurology International

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Section: Peripheral Nerve Fusionmentioning

confidence: 99%

Advancing the technology for head transplants: From immunology to peripheral nerve fusion

Canavero¹,

Ren²

2019

Surgical Neurology International

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“…assumptions; Bittner et al 17 concludes that the lack of peripheral nerve fusion in the study by Brown et al 14 . is likely due to the incorrect use of solutions 18 .…”

Section: Resultsmentioning

confidence: 95%

Untitled

2020

J Neurol Neuromed

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Introduction: Peripheral nerve injuries commonly result from trauma and can lead to devastating loss of sensory and motor function. A novel strategy to improve peripheral nerve regeneration is a chemical fusogen known as polyethylene glycol (PEG). Several animal studies have illustrated PEG's potential to help prevent axon loss after peripheral nerve injury. However, the relative rate of success and potential complications of these studies have not been definitively shown in the literature. The purpose of this systematic review is to evaluate the literature regarding the success of PEG adjunct treatment after peripheral nerve injury in preclinical models. Materials and Methods:The MEDLINE database was queried using the PubMed search engine with the following keywords and phrases: "polyethylene glycol" OR "PEG" AND "nerve" AND "fusion". All resulting articles were screened by two reviewers. Animal type, nerve type, injury type, type(s) of analyses, and overall superiority of outcomes were assessed.Results: One-hundred and seventy-nine articles were identified, and thirteen studies remained after the application of inclusion and exclusion criteria. Twelve of the thirteen studies utilized rats as the preclinical model, while one utilized a guinea pig. Superiority of peripheral nerve repair outcomes with adjunct PEG treatment compared to a control group was reported in eleven of thirteen studies. Conclusions: The majority of studies reported positive outcomes when using PEG; this indicates that PEG treatment has the potential to enhance peripheral nerve regeneration after injury. However, the results of some of these studies indicated several uncertainties that need to be addressed in future studies. These preclinical models may help guide clinicians regarding the use of PEG treatment in peripheral nerve repair.

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“…However, after taking into consideration the consistent physiology and histology within one species, that implication may be false. Bittner et al speculated that the unusual PEG fusion protocol used by Brown et al might not be optimal, and the lack of results of PEG fusion could be due to the use of incorrect solutions [61]. Issacs et al also did not observe enhanced nerve regeneration (measured by muscle contraction force and nerve diameter assessment) [48].…”

Section: Resultsmentioning

confidence: 99%

Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review

Paskal

Pietruski³

et al. 2019

IJMS

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Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair of nerve lesion does not always guarantee satisfactory motor and sensory function recovery. Therefore, enhancement of the regeneration process is a subject of many research strategies. It is believed that polyethylene glycol (PEG) mediates axolemmal fusion, thus enabling the direct restoration of axon continuity. It also inhibits Wallerian degeneration and recovers nerve conduction. This systemic review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, describes and summarizes published studies on PEG treatment efficiency in various nerve injury types and repair techniques. Sixteen original experimental studies in animal models and one in humans were analyzed. PEG treatment superiority was reported in almost all experiments (based on favorable electrophysiological, histological, or behavioral results). To date, only one study attempted to transfer the procedure into the clinical phase. However, some technical aspects, e.g., the maximal delay between trauma and successful treatment, await determination. PEG therapy is a promising prospect that may improve the surgical treatment of peripheral nerve injuries in the clinical practice.

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Surgical Technique and Other Protocols Used Probably Did Not Induce Polyethylene Glycol Fusion of Rat Facial Nerves

Cited by 3 publications

References 6 publications

Advancing the technology for head transplants: From immunology to peripheral nerve fusion

Advancing the technology for head transplants: From immunology to peripheral nerve fusion

Untitled

Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review

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