Surgical Target Selection in Cerebral Glioma Surgery: Linking Methionine (MET) PET Image Fusion and Neuronavigation

Rössler, Karl; Gatterbauer, Brigitte; Becherer, Alexander; Paul, Megan; Kletter, Kurt; Prayer, Daniela; Hoeftberger, Romana; Hainfellner, Johannes A.; Asenbaum, S.; Knosp, Engelbert

doi:10.1055/s-2007-991143

Cited by 24 publications

(26 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, areas with highest MET and FDG uptake were concordant in those gliomas, which showed an increased glucose metabolism. The value of MET-PET for targeting the biopsy is supported by the results of Roessler et al [33]: an increased MET uptake was detected in 26 of 27 gliomas, and allowed detection of anaplasia in five gliomas showing no Gd enhancement in MRI. The uptake in gliomas and the image contrast of FET appear to have similarities to those of MET [25].…”

Section: Discussionmentioning

confidence: 76%

Comparison of F-18 FET-PET with F-18 FDG-PET for biopsy planning of non-contrast-enhancing gliomas

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 76%

Comparison of F-18 FET-PET with F-18 FDG-PET for biopsy planning of non-contrast-enhancing gliomas

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In this respect, it is important to note that anaplastic gliomas are usually non-contrast-enhanced on MRI, and neoplastic cells almost always are found beyond areas of abnormal signal intensity [5]. PET with radiolabelled amino acid tracers has proved particularly useful in this challenging surgical situation [12,22]. Nevertheless, all patients with anaplastic gliomas in our series showed T1-Gd enhancement and therefore this sequence was used for surgery planning.…”

Section: Anaplastic Gliomasmentioning

confidence: 85%

“…Some groups have used MET PET for the management and surgery planning of brain tumours [21][22][23]. Pirotte et al have analysed the specific contribution of PET and MRI to the definition of the target volume and propose a two-step classification of the relative location of the projection of PET and MRI volumes after visual analysis.…”

Section: Introductionmentioning

confidence: 99%

Quantitative volumetric analysis of gliomas with sequential MRI and 11C-methionine PET assessment: patterns of integration in therapy planning

Arbizu

Tejada

Martí-Climent

et al. 2012

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…Roessler et al [36] looked at 27 patients with PET-targeted biopsies and found anaplastic foci could be recognised to aid biopsy targeting. Sadeghi et al [21] demonstrated in 14 patients that methionine (MET) PET provides an index of focal malignant activity.…”

Section: Pet/spectmentioning

confidence: 99%

Clinical applications of imaging biomarkers. Part 2. The neurosurgeon's perspective

Brodbelt¹

2011

BJR

View full text Add to dashboard Cite

ABSTRACT. Advances in imaging, including multivoxel spectroscopy, tractography, functional MRI and positron emission spectroscopy, are being used by neurosurgeons to target aggressive areas in gliomas, and to help identify tumour boundaries, functional areas and tracts. Neuro-oncological surgeons need to understand these techniques to help maximise tumour resection, while minimising morbidity in an attempt to improve the quality of patient outcome. This article reviews the evidence for the practical use of multimodal imaging in modern glioma surgery. DOI: 10.1259/bjr/19282704 ' 2011 The British Institute of RadiologyWhat are the aims of glioma surgery? Despite exciting advances in MRI biomarkers, surgery is still needed to provide representative specimens for histological and molecular examination, for tumour debulking and sometimes chemotherapeutic access. Multimodal MRI can have a role in all surgical aspects of tumour management.Gliomas are heterogeneous tumours that can lead to inaccuracies in diagnosis [1]. Areas of normal brain, inflammation, oedema, necrosis and active tumour of varying grades may coexist in a single patient [1][2][3]. Appropriate treatment requires representative sampling of the most aggressive part of the tumour. In enhancing tumours on CT or MRI, a portion of the contrast-enhanced section is targeted, whereas in unenhancing lesions perfusion, diffusion and spectroscopy can aid objective selection.There continues to be debate regarding the role of debulking surgery for glioma [4][5][6][7][8][9][10][11][12][13][14][15]. There is Class 2 evidence that resectional surgery (as defined on postoperative MRI) in high-grade glioma correlates with improved prognosis [4][5][6][7][8][9]. In low-grade gliomas, the evidence is less convincing, but many authors contend that macroscopic resection does provide benefit [10][11][12]. A significant reduction in tumour burden without morbidity is the surgical aim.Tumour boundaries are not clearly demonstrated by current clinical imaging techniques. McKnight et al [2] studied 68 patients with high-grade glioma using magnetic resonance spectroscopy (MRS) and targeted biopsies, and suggested that between one-third and one-half of the altered T 2 weighted signal seen on MRI is tumour. Price et al [16] have shown that tumour is present outside the T 2 weighted boundary. Silbergeld and Chicoine [17] were able to culture malignant glioma cells from histologically normal brain taken 4 cm from the contrastenhancing edge of high-grade gliomas. Spectroscopy, perfusion, diffusion and positron emission tomography (PET) imaging can help define tumour presence not seen on conventional imaging [2,3,16,18].Compounding factors for surgery include anatomical functional variability and, the distorting and infiltrating effects of tumours. The surgical procedure produces distortions. Coenen et al [19] demonstrated up to 12 mm of brain shift during surgery. Image guidance, with preoperative conventional MRI, can be helped by tractography, functional MRI and intraoperative re...

show abstract

Surgical Target Selection in Cerebral Glioma Surgery: Linking Methionine (MET) PET Image Fusion and Neuronavigation

Cited by 24 publications

References 11 publications

Comparison of F-18 FET-PET with F-18 FDG-PET for biopsy planning of non-contrast-enhancing gliomas

Comparison of F-18 FET-PET with F-18 FDG-PET for biopsy planning of non-contrast-enhancing gliomas

Quantitative volumetric analysis of gliomas with sequential MRI and 11C-methionine PET assessment: patterns of integration in therapy planning

Clinical applications of imaging biomarkers. Part 2. The neurosurgeon's perspective

Contact Info

Product

Resources

About