Surgical suture materials coated with a layer of hydrophilic Hydron gel

Abstract

SummarySurgical suture materials were coated with a layer of hydrophilic Hydron gel. By tests carried out on tissue cultures, it has been verified that this layer itself improves the tolerance of the fiber by the organism. In addition, appropriate biologically active substances (e.g., antibiotics), preventing either the development or spreading of an infection along the fiber, may be incorporated into the gel layer. Neither the knotting ability nor other mechanical properties of the fiber are influenced by the gel coating. Preliminary clinical experiments showed good results.

Synthetic Hydrogels for Biomedical Applications

“…In the simplest example of such a system, hydrogels can be saturated with solutions of various antibiotics and other drugs which will leach out to the surrounding tissue upon implantation. A number of papers describing such hydrogel drug delivery systems have already been mentioned (41)(42)(43)(44)(45)(46)95). The rate of drug delivery generally decreases rapidly with simple homogeneous hydrogels saturated with a drug solution.…”

Water transport in 2-hydroxyethyl methacrylate copolymer irradiated by ? rays in air and related phenomena

“…The 2-hydroxyethyl methacrylate (HEMA) copolymers have been widely studied and employed as biomaterials, including soft contact lenses, 1,2 kidney dialysis systems, 3,4 drug delivery systems 5,6 and artificial liver support systems. 7,8 The presence of a hydroxyl group and a carbonyl group on each repeated unit makes the polymers compatible with water, and the hydrophobic ␣-methyl group and backbone impart hydrolytic stability to the polymers and support the mechanical strength of the polymer matrix.…”

Hydrophilic-Hydrophobic Binary Systems of Poly(2-hydroxyethyl methacrylate) and Polycaprolactone. Part I: Synthesis and Characterization

“…The diffusion coefficient of the modified hydrogels was determined using Equation (3). These results show that crosslinking affects the diffusion behavior of PHEMA while the incorporation of up to 10% (w/w) of PCL in either crosslinked or linear PHEMA does not affect diffusion behavior.…”

“…PHEMA hydrogels possess low mechanical strength and tear easily when swollen in water. Due to the low mechanical properties of these materials in the hydrated state, there have been several attempts to prepare surface coatings on more structurally satisfactory materials [3,4]. However, surface coatings are subject to problems of surface damage, lack of adhesion and substrate modification.…”