Surgical stress reduces mortality from endotoxin shock

Kamei, Keitarou; Nimura, Yuji; Nagino, Masato; Aono, Keiya; Nakashima, Izumi

doi:10.1007/s00423-001-0261-y

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…This massive induction, apparently caused primarily by CLP, was significantly inhibited by the 24-h pre-HS ischemic conditioning of the organ. Similarly, in a mild surgical stress and endotoxin double-hit model, Kamei et al (46) found a significant reduction in mortality in the animals receiving both insults days apart with a corresponding inhibition in the endotoxin-induced increase in serum TNF-α and IL-6 levels.…”

Section: Discussionmentioning

confidence: 89%

Interaction of Hemorrhagic Shock and Subsequent Polymicrobial Sepsis on Gastrointestinal Motility

Overhaus¹,

Toegel²,

Bauer³

2009

Shock

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Understanding “two-hit” experimental models is crucial for the rational development of therapies for hemorrhagic shock (HS). We modeled the clinical scenario of HS followed by polymicrobial sepsis (cecal ligation and puncture [CLP]) to investigate the molecular and functional alterations that occur within the gastrointestinal tract. Control, HS, CLP, simultaneous HS + CLP, and HS + delayed CLP by 24 h groups of Sprague-Dawley rats were studied for gastrointestinal transit and in vitro colonic circular muscle contractility to bethanechol. Reverse transcription–polymerase chain reaction quantified IL-6, IL-10, and heme oxygenase 1 messenger RNA expression in the isolated colonic muscularis 6 h after insult. Myeloperoxidase-positive neutrophils were quantified in colonic muscularis whole mounts. Mortality at 24 h was significantly increased in simultaneous mild HS + CLP (88%) over control, mild HS, CLP alone, or HS + delayed CLP. Cecal ligation and puncture significantly delayed transit compared with controls and HS alone. Hemorrhagic shock + delayed CLP animals had normal transit. Colonic contractions were suppressed by 50% after CLP compared with controls and HS. In contrast, HS + delayed CLP displayed control levels of contractile responses to bethanechol. Cecal ligation and puncture and simultaneous HS + CLP caused significant inflammatory messenger RNA induction of IL-6, iNOS, IL-10, and heme oxygenase 1 compared with control and HS, and these responses were significantly suppressed in HS + delayed CLP colonic muscularis extracts. Neutrophils were significantly recruited into the colonic muscularis following CLP after 24 h compared with control and HS. This recruitment was significantly less in the HS + delayed CLP animals. These data demonstrate the ability of mild HS to precondition the animal and protect it against a delayed, but not simultaneous, polymicrobial event.

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Section: Discussionmentioning

confidence: 89%

Interaction of Hemorrhagic Shock and Subsequent Polymicrobial Sepsis on Gastrointestinal Motility

Overhaus¹,

Toegel²,

Bauer³

2009

Shock

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“…Using both variables provides a more accurate view of postoperative stress. Various cytokines have been used to quantify postoperative stress in both human and animal models [26,27], however, monitoring of these molecular markers have not been routinely used in clinical settings. The observations made in our current study can provide a basis to justify a more precise measurement of postoperative stress, including various inflammatory markers, in future studies.…”

Section: Discussionmentioning

confidence: 99%

Outcome Differences Between Gastroschisis Repair Methods

McNamara

Hartin

Escobar

et al. 2011

Journal of Surgical Research

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“…After opening the abdominal cavity with an incision of 1 cm length, the incision was closed by double layer suture (Vicryl 5.0; Fa Ethicon, Norderstedt, Germany). To prevent metabolic lapse postsurgery mice were provided with 5% glucose solution (Kamei et al., 2002). Additionally the mice were allowed glucose 5% ad libitum (The mean amount received was 6.55 ml/day per mouse in the saline group, and 6.85 ml/day per mouse in the ethanol group).…”

Section: Methodsmentioning

confidence: 99%

Effects of Ethanol on Cytokine Production After Surgery in a Murine Model of Gram‐Negative Pneumonia

Spies

Lanzke

Schlichting

et al. 2007

Alcoholism Clin & Exp Res

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Surgical stress reduces mortality from endotoxin shock

Abstract: Surgical stress reduces LPS-induced lethality through biphasically regulating the levels of TNF-alpha and IL-6 production.

Cited by 8 publications

References 28 publications

Interaction of Hemorrhagic Shock and Subsequent Polymicrobial Sepsis on Gastrointestinal Motility

Interaction of Hemorrhagic Shock and Subsequent Polymicrobial Sepsis on Gastrointestinal Motility

Outcome Differences Between Gastroschisis Repair Methods

Effects of Ethanol on Cytokine Production After Surgery in a Murine Model of Gram‐Negative Pneumonia

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