Surgical site infections with special reference to methicillin resistant Staphylococcus aureus: experience from a tertiary care referral hospital in North India

Ranjan, K. P.; Ranjan, Neelima; Gandhi, Shashi

doi:10.5455/2320-6012.ijrms20130514

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…S. aureus was isolated from a total of 12 samples, out of these, 5 (41.67%) were methicillin-resistant S. aureus (MRSA), and the remaining 7 (58.33%) were methicillinsensitive S. aureus (MSSA). A study done by Ranjan et al showed that 27.96% of S. aureus were methicillin-resistant strains, which is also in line with our results [19].…”

Section: Antimicrobial Susceptibility Pattern In Gram-positive Coccisupporting

confidence: 93%

A Study of Bacterial Pathogens Causing Surgical Site Infection and Their Antimicrobial Susceptibility in Tertiary Care Hospital

GOYAL

BHAVSAR

CHAUDHARY

et al. 2022

Asian J Pharm Clin Res

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Objectives: Surgical site infections (SSIs) remain a common and global problem that contributes to significant morbidity and mortality, prolongs hospital stay, and consequently increases health-care costs. Bacterial resistances pose a challenge and complicated the SSI treatment. This study aimed to evaluate the bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection. Methods: Patients who underwent either elective or emergency surgical procedures were enrolled in this study. For those who developed surgical site infections, specimens from the surgical site were collected and processed at the microbiology laboratory at the tertiary health-care center, Ahmedabad. Results: Out of the 5003 patients, 34 developed SSI. In our study, 37 bacteria were isolated from 34 samples subjected to culture. Thirty-two samples showed monomicrobial growth and two showed polymicrobial growth. Among them, 14 (38%) were Gram-positive cocci, out of which 12 (85.7%) were Staphylococcus aureus and 2 (14.3%) were Enterococci spp. and 23 (62%) were Gram-negative bacilli, there were 21 (91.3%) enterobacteriaceae, out of which 5 (23.8%) were Escherichia coli, 1 (4.8%) were Proteus mirabilis, 15 (71.4%) Klebsiella spp. and 02 (8.7%) non-fermenters of which Pseudomonas aeruginosa and Acinetobacter baumannii. Conclusions: Gram-negative bacteria were the most dominant isolates from surgical sites in the study area. Among them, Klebsiella spp. were the most common bacteria isolated from surgical site specimens. In our study, there is high antibiotic resistance observed which raises serious concerns and mandates strict antibiotic policy as well as antimicrobial stewardship.

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Section: Antimicrobial Susceptibility Pattern In Gram-positive Coccisupporting

confidence: 93%

A Study of Bacterial Pathogens Causing Surgical Site Infection and Their Antimicrobial Susceptibility in Tertiary Care Hospital

GOYAL

BHAVSAR

CHAUDHARY

et al. 2022

Asian J Pharm Clin Res

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“…Almost similar results were observed in studies from Uttarakhand, Gwalior, and Karnataka where vancomycin, teicoplanin, and linezolid showed 100% sensitivity to staphylococcal isolates. [253436] This finding could have a relevant clinical use in the antibiotic policy guidelines for hospitals. In this study, newer antibiotics like quinupristin, dalfopristin, and daptomycin were not tested, however, few reports from India have shown promising results with these antibiotics.…”

Section: Discussionmentioning

confidence: 86%

“…[30] In the present study, S.aureus comprised of 45.3% of SSIs, a finding which was in tandem with the previous studies by Negi et al (50.4%), Ranjan et al (34%), Naik et al (32.2%), and Krishna et al (31.3%). [25343536] Infections with S. aureus is most likely associated with endogenous source as it is a member of the skin and nasal flora, and also with contamination from the environment, surgical instruments, or from hands of healthcare workers (HCW). [37] Literature revealed that 80% of the healthy individuals across the world harbor S. aureus in their skin or anterior nares and integrity of the skin if breached during any surgery could commonly cause skin and soft tissue infections with this organism.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus: A predominant cause of surgical site infections in a rural healthcare setup of Uttarakhand

Pal

Sayana

Joshi

et al. 2019

J Family Med Prim Care

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Introduction:Surgical site infections (SSIs) represent the second most common type of healthcare-associated infections and remain a relatively common postoperative complication and the most common reason for readmission after surgery. SSIs have dire implications for the surgeon, patient, and institution which often require prolonged treatment, impose an economic burden and double the risk of patient mortality. Staphylococcus aureus is currently the most common cause of SSIs causing as many as 37% of cases of SSIs in community hospitals with methicillin-resistant S. aureus (MRSA) of particular concern.Materials and Methods:This cross-sectional study was conducted from January 2014 to December 2014 in a rural tertiary care hospital of Pauri Garhwal district of Uttarakhand state, India. Samples were collected using sterile cotton swabs from 269 patients clinically diagnosed with SSIs and were processed as per standard microbiological techniques. Antimicrobial susceptibility testing was done using a modified Kirby-Bauer disc diffusion method.Results:Out of 1294 patients, 269 (20.8%) were found to have SSIs and samples were collected from them. Out of a total of 269 samples, 258 (95.9%) yielded bacterial growth and 267 bacterial isolates were obtained. S. aureus (45.3%) was the commonest organism followed by Escherichia coli (13.9%), Pseudomonas aeruginosa (6.7%), and Proteus species (4.9%). Antimicrobial profile of S. aureus revealed maximum sensitivity to rifampicin, linezolid, teicoplanin, vancomycin, and amikacin whereas ampicillin, cefazolin, and gentamicin were found to be least sensitive.Conclusion:S. aureus played a predominant role in the etiology of SSIs in this hospital with MRSA being a major concern as the treatment options for such resistant strains are limited. Reduction in SSI rates can lead to both better clinical outcomes for patients and cost savings for hospitals. Adherence to strict infection control measures, maintenance of proper hand hygiene and optimal preoperative, intraoperative, and postoperative patient care can surely reduce the incidence of SSIs. A multifaceted approach involving the surgical team, microbiologist, and the infection control team is required to provide quality surgical services.

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“…We also compared MRSA isolates with other MSSA isolates with regard to the sensitivity pattern among the antibiotics and the resistance rates for MRSA isolates were higher than MSSA for all the antibiotics. Ranjan KP et al [18] also observed in their study that multidrug resistance was more common in MRSA than MSSA.…”

Section: Discussionmentioning

confidence: 80%

Surgical Site Infections Causes and the Burden of Staphylococcus Aureus in these Infections with their Antibiotic Susceptibility Pattern

Kannaiyan

Ragunathan²,

Venkatachalam

2018

APALM

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Background: Surgical site infections (SSI) set hurdles in the healing course of a significant proportion of abdominal surgical patients and thus associated with excessive health care costs. Staphylococcus aureus remains the principal causative agent in these infections. Also the emergence of multidrug resistant bacterial strains further complicates the recovery course of the patients and thus adds burden to both the patients and the surgeon. The intention of this study is to evaluate the etiology of SSI, to establish the incidence of S aureus and to determine their antimicrobial susceptibility pattern in patients with SSI. Methods: A cross section study was done in Aarupadai veedu medical college in patients attending surgery outpatient department for SSI. Purulent material was collected either with syringe or 2 sterile swabs and was sent to the microbiology department. The sample was processed as per standard guidelines, identified and antibiotic susceptibility was done for S.aureus. Result: Among the 63 SSI patients, 50 (79.4%) were culture positive. The most frequently isolated organism was S aureus 23 (36.5%) isolates. Among them methicillin resistant S.Aureus (MRSA) was 9 (39.1%). Both Methicillin sensitive S.aureus (MSSA) and MRSA were all sensitive to linezolid and vancomycin. Majority of the isolates were sensitive to amikacin and clindamicin. Conclusion: Thus our study concludes S. aureus as the foremost etiological agent of SSI, and treatment is further complicated by emerging multidrug resistant MRSA where empirical therapy can be started with clindamicin, amikacin in moderate risk cases and linezolid, vancomycin in high risk cases.

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Surgical site infections with special reference to methicillin resistant Staphylococcus aureus: experience from a tertiary care referral hospital in North India

Cited by 8 publications

References 8 publications

A Study of Bacterial Pathogens Causing Surgical Site Infection and Their Antimicrobial Susceptibility in Tertiary Care Hospital

A Study of Bacterial Pathogens Causing Surgical Site Infection and Their Antimicrobial Susceptibility in Tertiary Care Hospital

Staphylococcus aureus: A predominant cause of surgical site infections in a rural healthcare setup of Uttarakhand

Surgical Site Infections Causes and the Burden of Staphylococcus Aureus in these Infections with their Antibiotic Susceptibility Pattern

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