Surgical Site Infection by Methicillin Resistant Staphylococcus aureus– on Decline?

Bhattacharya, Susmita; Pal, Krishan; Jain, Sonia; Chatterjee, Shiv Sekhar; Konar, Jayashree

doi:10.7860/jcdr/2016/21664.8587

Cited by 37 publications

(39 citation statements)

References 21 publications

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“…In our study, the other organisms isolated included Diphtheroids (12%), E. coli (10.5%), Klebsiella (7%), Pseudomonas (7%), and Acinetobacter (2%). The main gram-negative offenders in our study were E. coli, followed by Klebsiella and Pseudomonas, this was similar to that in studies done by Bhattacharya and Anjum et al [5,19]. No growth of Streptococci was obtained.…”

Section: Microbiological Pro Lesupporting

confidence: 92%

“…Among the 19 cases with Staph aureus growth, 60% constituted MRSA. Another study by Bhattacharya et al also showed the highest culture of Staph aureus (35%) among the SSI, (of which MRSA was 26%), others being E. coli (20%), Klebsiella (18%), Pseudomonas (8%) and Acinetobacter (7.5%) [19]. In our study, the other organisms isolated included Diphtheroids (12%), E. coli (10.5%), Klebsiella (7%), Pseudomonas (7%), and Acinetobacter (2%).…”

Section: Microbiological Pro Lementioning

confidence: 85%

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Prospective Analysis of Wound Infection Following Cesarean Section

Shukkur

Rao

Zubair

2020

Preprint

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Background: To study the risk factors among women who develop postoperative wound infection following caesarean section, and to analyze the microbiological pattern and antibiotic sensitivity. Method: This prospective hospital-based cross-sectional study conducted in government Lady Goschen Hospital, Mangalore, between October 2016 to March 2018, enrolled women who developed surgical site infections (SSI) within 30 days of caesarean delivery performed in the hospital. Descriptive statistics were used for socio-demographic variables and appropriate univariate and multivariate analysis used to find the association between continuous and categorical variables with a p-value of <0.05 taken as statistically significant.Results: Out of 4540 cesarean deliveries, 52 (1.1%) cases developed SSI. Surgical site infections were found significantly associated with maternal age above 25years, BMI>27Kg/m2 (p<0.001), hypertension, diabetes (p<0.001), the urgency of caesarean delivery, prolonged operative duration, technique and suture material (p<0.001) used. Poliglecaprone (monofilament) was found suitable for subcutaneous tissue and skin closure. Out of 38 cases with microbial growth, 52% cultured Staphylococcus aureus with 60% displaying methicillin resistance, followed by Diphtherioids (22%) and Pseudomonas (10.5%). Majority isolates showed higher sensitivity to Linezolid, Clindamycin and Vancomycin.Conclusion: Apart from maternal factors, the surgeon’s operative skill & technique, and suture material also contribute significantly to the development of SSI. A developing trend towards resistance to higher antibiotics was noted among Methicillin-resistant Staphylococcus aureus. Gentamicin and Linezolid were found as effective as second-line agents. Hence maintenance of quality asepsis and a hospital-based antibiotic policy is vital.

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Section: Microbiological Pro Lesupporting

confidence: 92%

Section: Microbiological Pro Lementioning

confidence: 85%

Prospective Analysis of Wound Infection Following Cesarean Section

Shukkur

Rao

Zubair

2020

Preprint

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“…28 These infections are usually caused by exogenous or endogenous microorganisms that enter the operative wound during the course of the surgery. 29 In our study over 32 of 37 patients with history surgical site infection had positive result culture. These wound infections may have occurred at hospital and recognized to be associated with an infection before-after or during surgery, extended length of hospital stays and prolonged or permanent disability.…”

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confidence: 54%

Microbial Pattern and Antibiotic Susceptibility in Pediatric Intensive Care Unit Dr. Soetomo Hospital, Surabaya

A.A.W.

Irwanto

Dharmawati

et al. 2019

IJTID

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Gram-negative bacterial are known as common pathogen caused infection in Pediatric Intensive Care Unit (PICU). Microbial Pattern and Antibiotic Susceptibility are needed as clinical data for selected appropriate antibiotic therapy. In PICU Dr. Soetomo hospital until now still lacking of Microbial Pattern and Antibiotic Susceptibility data. This descriptive study is to recognized Microbial Pattern and Antibiotic Susceptibility in PICU patients from blood, urine, sputum, stool, cerebrospinal fluid, endotracheal tube, pus swab and pleural fluid culture specimens. Patients whose admitted into PICU without signs of infections were excluded from the study. The inclusion criteria are patients with sign infection as follows: fever < 36,5°C or > 37.5°C, leukocyte < 4000/mm 3 or > 10000/mm 3 , marker infections CRP >10 mg/L or PCT >0,3 ng/mL, bradycardia or tachycardia, tachypnea, infiltrates on chest X-ray, turbid urine, dysuria, thrombophlebitis, abdominal pain or tenderness, and mucous or skin lesion. Medical record data from 2011 to 2016, revealed 1138 patients had positive microbial culture result, wherein positive result came from blood 44.46%, urine 19.15%, sputum 11.59%, stool 8.96%, cerebrospinal fluid 7.50%, endotracheal tube 4.04%, pus swab 2.89%, and pleural fluid 1.41%. The microorganisms found in PICU Dr. Soetomo was dominated with gram negative bacteria. Commonest bacterial that recognized from blood was B. cepacea, urine was E. coli, sputum was P. aeruginosa, Stool was E. coli, Cerebrospinal fluid was S. cohnii, endotracheal tube was K. pneumoniae ESBL, pus swab was S. aureus, and pleural fluid was S. maltophilia. Both gram-negative bacteria and gram-positive bacteria isolates revealed multiple drug resistance to commonly used antibiotic, but still had good susceptibility for antibiotic such as; amikacin, cefoperazone-sulbactam, linezolid, vancomycin and carbapenem group. ABSTRAKBakteri gram negatif merupakan patogen tersering penyebab infeksi di ruang rawat intensif anak. Pola bakteri dan kepekaan antibiotik diperlukan sebagai data klinis dalam pemilihan terapi antibiotik yang sesuai. Di ruang rawat intensif anak RS.Dr. Soetomo hingga saat ini masih sangat kekurangan data mengenai pola bakteri dan kepekaan antibiotik. Penelitian deskriptif ini bertujuan untuk membuat pola bakteri dan kepekaan antibiotika pada pasien yang dirawat di ruang rawat intensif anak dari spesimen darah, urin, sputum, feces, cairan serebrospinal,tabung endotrakeal (ETT), pus luka dan cairan pleura. Pasien yang masuk ke PICU yang tidak menunjukkan tanda dan gejala infeksi di eklusi dari penelitian. Kriteria inklusi pada penelitian ini adalah ditemukannya tanda dan gejala infeksi, antara lain ;demam < 36,5°C or > 37.5°C, kadar leukosit darah < 4000/mm3 or > 10000/mm3, marker infeksi CRP >10 mg/L or PCT >0,3 ng/mL, bradikardi atau takikardi, takipneu, gambaran infiltrate pada radiologi paru,urine yang keruh, nyeri berkemih, tromboplebitis, nyeri perut, dan lesi pada mukosa atau kulit. Dari data rekam medis dari tahun 2011 sampai...

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“…In addition, prior studies in India by Surange et al [13] , Subramanian et al [14] and recent study by Kownhar et al [15] have stated the occurrence of S. aureus to be 34.2%, 30.9% and 37% respectively. Past studies revealed that 80% of healthy individuals harbor S.aureus in their skin or anterior nares and hence causes post operative wound infection when integrity of the skin is breached during surgery [16] .…”

Section: Discussionmentioning

confidence: 99%

“…The management of SSI caused by S.aureus is further complicated due to the emerging multi drug resistant strains, particularly the methicillin resistant S.aureus (MRSA), which also represents the leading cause of S.aureus associated nosocomial infections [2] . MRSA has become a hospital superbug throughout the world [16] . In the current study 39.1% of S.aureus isolates were methicillin resistant.…”

Section: Discussionmentioning

confidence: 99%

Surgical Site Infections Causes and the Burden of Staphylococcus Aureus in these Infections with their Antibiotic Susceptibility Pattern

Kannaiyan

Ragunathan²,

Venkatachalam

2018

APALM

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Background: Surgical site infections (SSI) set hurdles in the healing course of a significant proportion of abdominal surgical patients and thus associated with excessive health care costs. Staphylococcus aureus remains the principal causative agent in these infections. Also the emergence of multidrug resistant bacterial strains further complicates the recovery course of the patients and thus adds burden to both the patients and the surgeon. The intention of this study is to evaluate the etiology of SSI, to establish the incidence of S aureus and to determine their antimicrobial susceptibility pattern in patients with SSI. Methods: A cross section study was done in Aarupadai veedu medical college in patients attending surgery outpatient department for SSI. Purulent material was collected either with syringe or 2 sterile swabs and was sent to the microbiology department. The sample was processed as per standard guidelines, identified and antibiotic susceptibility was done for S.aureus. Result: Among the 63 SSI patients, 50 (79.4%) were culture positive. The most frequently isolated organism was S aureus 23 (36.5%) isolates. Among them methicillin resistant S.Aureus (MRSA) was 9 (39.1%). Both Methicillin sensitive S.aureus (MSSA) and MRSA were all sensitive to linezolid and vancomycin. Majority of the isolates were sensitive to amikacin and clindamicin. Conclusion: Thus our study concludes S. aureus as the foremost etiological agent of SSI, and treatment is further complicated by emerging multidrug resistant MRSA where empirical therapy can be started with clindamicin, amikacin in moderate risk cases and linezolid, vancomycin in high risk cases.

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Surgical Site Infection by Methicillin Resistant Staphylococcus aureus– on Decline?

Cited by 37 publications

References 21 publications

Prospective Analysis of Wound Infection Following Cesarean Section

Prospective Analysis of Wound Infection Following Cesarean Section

Microbial Pattern and Antibiotic Susceptibility in Pediatric Intensive Care Unit Dr. Soetomo Hospital, Surabaya

Surgical Site Infections Causes and the Burden of Staphylococcus Aureus in these Infections with their Antibiotic Susceptibility Pattern

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