Surgical site infection associated with the use of bovine serum albumine-glutaraldehyde surgical adhesive (BioGlue®) in cranial surgery: a case–control study

Abstract

BioGlue seems to increase the risk of SSI for patients who underwent craniotomy, especially when associated with synthetic dural graft. BioGlue triggers an intense inflammatory response, which causes wound breaches allowing bacteria to spread down in the wound, and then creates an ideal environment for bacterial growth.

Risk factors and outcomes associated with surgical site infections after craniotomy or craniectomy

“…20 Procedure-related risk factors include emergency procedure, 17 no antimicrobial prophylaxis, 19 longer procedure duration, 12,14,18,19 postoperative CSF leakage, [17][18][19]35 and early reoperation. 17,19,30,32 However, inclusion criteria for these studies varied and most studies evaluated specific subgroups of patients (for example, elective procedures) or specific infections (such as meningitis).…”

Late wound healing problems after use of BioGlue(R) for apical hemostasis during transapical aortic valve implantation

“…A similar problem with wound healing after use of BioGlue has been already documented in pediatric and adult patients who underwent craniotomy [7]. It occurred weeks or months after the primary neurosurgical procedure.…”

Risk factors and outcomes associated with surgical site infections after craniotomy and craniectomy

“…France (Gaberel et al, 2011;Korinek et al, 1997;Korinek et al, 2005;Korinek et al, 2006), Japan (Shinoura et al, 2004), and Mexico (Sanchez-Arenas et al, 2010). The results of studies done in other countries may not be generalizable to the population in the US.…”

“…Two studies included craniotomies done as treatment for tumors (Shinoura et al, 2004;Hardy et al, 2010), and one study included craniotomy procedures that did not involve placing implants (Sanchez-Arenas et al, 2010). Three studies evaluated only meningitis (Korinek et al, 2006;Kourbeti et al, 2007;Reichert et al, 2002), and one study evaluated patients with SSIs that needed a second operation to cleanse the wound (Gaberel et al, 2011). Two studies included patients with any type of SSI (Korinek et al, 1997;Sanchez-Arenas et al, 2010).…”