Surgical site infection after intracorporeal and extracorporeal anastomosis in laparoscopic left colectomy for colon cancer: a multicenter propensity score-matched cohort study

Guo, Yuchen; Li, Kexuan; Li, He; Tong, Wei; Chen, Yan; Wu, Bin; Lin, Guole; Qiu, Huizhong; Xu, Lai; Xiao, Yi; Wang, Quan

doi:10.1007/s00464-023-10093-y

Cited by 4 publications

(13 citation statements)

References 29 publications

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“…The duration of surgery was reported in 7 studies. 28 – 34 Minimally-invasive left colectomy performing IA was associated with a significant longer operative time compared to EA (SMD 0.36, 95% CI 0.14–0.59, p = 0.001) (Fig. 3 d).…”

Section: Resultsmentioning

confidence: 94%

“…The study by Teramura et al 35 included a subgroup analysis of 43 patients with left-sided colectomy among a total of 283 cases with both left-and right sided colectomies. The male to female ratio was 436:271 in 7 studies 28 – 34 with available demographic data for IA and EA patients undergoing left colectomy. Except for 3 studies 30 , 31 , 34 with a multi-center design, 5 studies 28 , 29 , 32 , 33 , 35 were single-center studies.…”

Section: Resultsmentioning

confidence: 99%

“…The male to female ratio was 436:271 in 7 studies 28 – 34 with available demographic data for IA and EA patients undergoing left colectomy. Except for 3 studies 30 , 31 , 34 with a multi-center design, 5 studies 28 , 29 , 32 , 33 , 35 were single-center studies. The operative indication was malignant tumors in 7 studies 28 – 34 while Teramura et al 35 also included benign diseases.…”

Section: Resultsmentioning

confidence: 99%

“…Except for 3 studies 30 , 31 , 34 with a multi-center design, 5 studies 28 , 29 , 32 , 33 , 35 were single-center studies. The operative indication was malignant tumors in 7 studies 28 – 34 while Teramura et al 35 also included benign diseases. Laparoscopic and laparoscopic-assisted left colectomy was performed in all studies while robotic approaches were not reported.…”

Section: Resultsmentioning

confidence: 99%

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Intracorporeal Versus Extracorporeal Colo-colic Anastomosis in Minimally-invasive Left Colectomy: a Systematic Review and Meta-analysis

Vaghiri,

Prassas,

Krieg

et al. 2023

Journal of Gastrointestinal Surgery

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Purpose The primary aim was to investigate the operative outcomes of intracorporeal (IA) and extracorporeal (EA) anastomosis in left-sided minimally-invasive colectomy. Methods A comprehensive literature search was conducted for studies comparing operative outcomes and follow-up data of IA versus EA in minimally-invasive left colectomy. Studies that investigated recto-sigmoid resections using transanal circular staplers were excluded. Data from eligible studies were extracted, qualitatively assessed, and included in a meta-analysis. Odds ratios (ORs) and mean differences with 95 per cent confidence intervals were calculated. Results Eight studies with a total of 750 patients were included (IA n = 335 versus EA n = 415). IA was associated with significantly lower overall morbidity (OR 0.40, 95% CI 0.26–0.61, p < 0.0001) and less frequent surgical site infection (SSI) (OR 0.27, 95% CI 0.12–0.61, p = 0.002) as primary outcomes compared to EA. Of the secondary outcomes, length of incision (SMD -2.51, 95% CI -4.21 to -0.81, p = 0.004), time to first oral diet intake (SMD -0.49, 95% CI -0.76 to -0.22, p = 0. 0004) and time to first bowel movement (SMD -0.40, 95% CI -0.71 to -0.09, p = 0.01) were significantly in favor of IA, while operative time was significantly shorter in the EA group (SMD 0.36, 95% CI 0.14–0.59, p = 0.001). Conclusions IA proves to be a safe and feasible option as it demonstrates benefits in terms of lower overall morbidity, fewer rates of SSI, smaller incision length, and faster postoperative gastrointestinal recovery despite a longer operative time compared to EA.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Intracorporeal Versus Extracorporeal Colo-colic Anastomosis in Minimally-invasive Left Colectomy: a Systematic Review and Meta-analysis

Vaghiri,

Prassas,

Krieg

et al. 2023

Journal of Gastrointestinal Surgery

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“…In terms of comparisons with the laparoscopic approach, there are few but promising ndings for R-TIA. [25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Minimally Invasive Left Colectomy with Total Intracorporeal Anastomosis versus Extracorporeal Anastomosis. A single center cohort study. Stage 2b IDEAL framework for evaluating surgical innovation

Serra-Aracil,

Gómez-Torres,

Torrecilla-Portoles

et al. 2023

Preprint

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Purpose Performing intracorporeal anastomoses in minimally invasive colon surgery appears to provide better short-term outcomes for patients with colon cancer. The aim of the study is to compare surgical aspects and short-term outcomes between intracorporeal and extracorporeal techniques in left colectomies with both laparoscopic and robotic approaches and evaluate advantages and disadvantages of intracorporeal anastomosis according to IDEAL framework (Exploration, stage 2b). Methods This is a single center, ambispective cohort study comparing total intracorporeal anastomosis (TIA) and standard surgery with extracorporeal anastomosis (EA). Patients with colon cancer treated by left colectomy, sigmoidectomy and high anterior resection by total intracorporeal anastomosis between May 2020 and January 2023 without exclusion criteria were prospectively included in a standardized database. Short-term outcomes in the group undergoing TIA were compared with a historical EA cohort. The main assessment outcomes were intraoperative complications, postoperative morbidity according to the Clavien-Dindo scale and the comparison of pathological. We conducted a preliminary comparative study within the TIA group between approaches, a primary analysis between the two anastomotic techniques, and a propensity score matched analysis including only the laparoscopic approach, between both anastomotic techniques. Results Two hundred and forty-six patients were included: 103 who underwent TIA, thirty-five of them with laparoscopic approach and 68 with robotic approach, and a comparison group comprising another 103 eligible consecutive patients who underwent laparoscopic EA. There were no statistically significant differences between the two groups in terms of demographic variables. No statistically significant differences were observed in anastomotic dehiscence. Intraoperative complications appear to be fewer in the TIA group, with a higher inflammatory response. Relevant anastomotic bleeding and the number of retrieved lymph nodes seem to be higher in EA group. Nevertheless, no differences were observed in terms of overall morbidity. Conclusion Minimally invasive left colectomy with intracorporeal resection and anastomosis is technically feasible and safe suing either a laparoscopic or a robotic approach. Clinical data from this cohort demonstrate outcomes comparable to those achieved through the conventional EA procedure in relation to postoperative morbidity and oncological efficacy, with indications suggesting that the utilization of robotic-assisted techniques may play a contributing role in enhancing overall treatment outcomes.

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Minimally invasive left colectomy with total intracorporeal anastomosis versus extracorporeal anastomosis. A single center cohort study. Stage 2b IDEAL framework for evaluating surgical innovation

Serra-Aracil,

Gómez-Torres,

Torrecilla-Portoles

et al. 2024

Langenbecks Arch Surg

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Purpose Performing intracorporeal anastomoses in minimally invasive colon surgery appears to provide better short-term outcomes for patients with colon cancer. The aim of the study is to compare surgical aspects and short-term outcomes between intracorporeal and extracorporeal techniques in left colectomies with both laparoscopic and robotic approaches and evaluate advantages and disadvantages of intracorporeal anastomosis according to IDEAL framework (Exploration, stage 2b). Methods This is a single center, ambispective cohort study comparing total intracorporeal anastomosis (TIA) and standard surgery with extracorporeal anastomosis (EA). Patients with colon cancer treated by left colectomy, sigmoidectomy and high anterior resection by total intracorporeal anastomosis between May 2020 and January 2023 without exclusion criteria were prospectively included in a standardized database. Short-term outcomes in the group undergoing TIA were compared with a historical EA cohort. The main assessment outcomes were intraoperative complications, postoperative morbidity according to the Clavien-Dindo scale and the comparison of pathological. We conducted a preliminary comparative study within the TIA group between approaches, a primary analysis between the two anastomotic techniques, and a propensity score matched analysis including only the laparoscopic approach, between both anastomotic techniques. Results Two hundred and forty-six patients were included: 103 who underwent TIA, 35 of them with laparoscopic approach and 68 with robotic approach, and a comparison group comprising another 103 eligible consecutive patients who underwent laparoscopic EA. There were no statistically significant differences between the two groups in terms of demographic variables. No statistically significant differences were observed in anastomotic dehiscence. Intraoperative complications are fewer in the TIA group, with a higher C-Reactive Protein levels. Relevant anastomotic bleeding and the number of retrieved lymph nodes were higher in EA group. Nevertheless, no differences were observed in terms of overall morbidity. Conclusion Minimally invasive left colectomy with intracorporeal resection and anastomosis is technically feasible and safe suing either a laparoscopic or a robotic approach. Clinical data from this cohort demonstrate outcomes comparable to those achieved through the conventional EA procedure in relation to postoperative morbidity and oncological efficacy, with indications suggesting that the utilization of robotic-assisted techniques may play a contributing role in enhancing overall treatment outcomes.

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Surgical site infection after intracorporeal and extracorporeal anastomosis in laparoscopic left colectomy for colon cancer: a multicenter propensity score-matched cohort study

Cited by 4 publications

References 29 publications

Intracorporeal Versus Extracorporeal Colo-colic Anastomosis in Minimally-invasive Left Colectomy: a Systematic Review and Meta-analysis

Intracorporeal Versus Extracorporeal Colo-colic Anastomosis in Minimally-invasive Left Colectomy: a Systematic Review and Meta-analysis

Minimally Invasive Left Colectomy with Total Intracorporeal Anastomosis versus Extracorporeal Anastomosis. A single center cohort study. Stage 2b IDEAL framework for evaluating surgical innovation

Minimally invasive left colectomy with total intracorporeal anastomosis versus extracorporeal anastomosis. A single center cohort study. Stage 2b IDEAL framework for evaluating surgical innovation

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