Surgical Salvage After Radiotherapy for Advanced Laryngopharyngeal Carcinoma

Davidson, J.; Keane, Thomas J.; Brown, Dale; Freeman, Jeremy L.; Gullane, Patrick; Irish, Jonathan C.; Rotstein, Lorne; Pintilie, Melania; Cummings, Bernard

doi:10.1001/archotol.1997.01900040056009

Cited by 61 publications

(43 citation statements)

References 15 publications

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“…The main cause of death was locoregional recurrence. These results agree strongly with those of previous studies by Davidson et al 6 and Jones, 14 who reported 5-year survival rates of 18% and 23%, respectively.…”

Section: Commentsupporting

confidence: 94%

“…In contrast, Champell and Goepfert 4 and Nibu et al 5 published 5-year survival rates of 64% and 86%, respectively, but only T1 and T2 disease were included in their studies. In agreement with other authors, 6 survival in our series was influenced mainly by the recurrent and not the initial tumor stage. Although there was a considerably large subgroup of patients with small initial tumors that could not be controlled by radiotherapy, partial laryngectomy as a salvage procedure was seldom possible because of tumor progression ending in more advanced recurrent tumor stages.…”

Section: Commentsupporting

confidence: 94%

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Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx

Stoeckli

Pawlik²,

Lipp³

et al. 2000

Arch Otolaryngol Head Neck Surg

121

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Salvage surgery in laryngeal cancer achieves good results, especially for small recurrences. Because of tumor progression, larynx preservation is seldom possible at the time of salvage. Salvage surgery in hypopharyngeal cancer shows poor survival regardless of tumor stage and despite radical surgical procedures, and can be recommended only for carefully selected patients. Arch Otolaryngol Head Neck Surg. 2000;126:1473-1477

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Section: Commentsupporting

confidence: 94%

Section: Commentsupporting

confidence: 94%

Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx

Stoeckli

Pawlik²,

Lipp³

et al. 2000

Arch Otolaryngol Head Neck Surg

121

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“…If a patient with tumor recurrence is neither eligible for surgery nor eligible for radiotherapy, then the treatment approach is the same as that for patients with metastatic disease. The overall 5-year survival rate of patients with local recurrence who undergo salvage surgery varies greatly from 22 to 66% (14)(15)(16)(17). One previous study has even shown the 5-year survival rate in this patient population to be as low as 2% (4).…”

Section: Introductionmentioning

confidence: 99%

Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study

Zhu

et al. 2015

Oncology Letters

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Abstract. The aim of the present retrospective analysis was to evaluate the treatment results for recurrent laryngeal cancer and to analyze the factors that may affect survival. A retrospective review was performed in 309 patients with recurrent laryngeal carcinoma, 224 of whom were treated between 1996 and 2009 at Sun Yat-Sen University Cancer Center (Guangzhou, Guangdong, China) and 85 of whom were treated between 2006 and 2013 at Zhejiang Cancer Hospital (Hangzhou, Zhejiang, China). The Kaplan-Meier method with the log-rank computation was used for the analysis of survival. The Cox proportional hazards model was applied to identify covariates that were significantly associated with overall survival. The actuarial 3-, 5-and 10-year survival rates were 68.9, 53.6 and 35.7%, respectively. Univariate analysis indicated that the following factors were associated with survival: Age, smoking index, tumor grade, primary tumor site, nodal status of the primary tumor, initial T stage, initial Union for International Cancer Control stage, initial treatment (radiotherapy or chemotherapy), disease-free interval, eligibility for surgery and extent of recurrence. Multivariate analysis of these factors indicated that the initial T stage, tumor grade, nodal status, disease-free interval and eligibility for surgery were significantly associated with survival. Overall, these results indicate that initial tumor stage T1 or T2, a high differentiation rate, no initial cervical lymph node metastasis, a long disease-free interval and a strong indication for salvage surgery are good prognostic factors for the survival of patients with recurrent laryngeal carcinoma.

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“…The actuarial 3-year rate of late toxicity (RTOG Grade 3 or 4) was not increased in the HF group (6% versus 11%, p= 0.18). The risk of post-surgical morbidity in those patients who underwent salvage surgery was comparable in each group (13). Unexpectedly, there was a significant advantage for HF over CF in the 3-year overall survival rate (53% versus 38%, p = 0.02).…”

Section: The Princess Margaret Hospital Trialmentioning

confidence: 86%

Benefits of Accelerated Hyperfractionation for Head and Neck Cancer

Cummings

1999

Acta Oncologica

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Surgical Salvage After Radiotherapy for Advanced Laryngopharyngeal Carcinoma

Cited by 61 publications

References 15 publications

Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx

Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx

Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study

Benefits of Accelerated Hyperfractionation for Head and Neck Cancer

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