Surgical Salvage After Radiotherapy for Advanced Laryngopharyngeal Carcinoma

Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx

“…The main cause of death was locoregional recurrence. These results agree strongly with those of previous studies by Davidson et al 6 and Jones, 14 who reported 5-year survival rates of 18% and 23%, respectively.…”

“…In contrast, Champell and Goepfert 4 and Nibu et al 5 published 5-year survival rates of 64% and 86%, respectively, but only T1 and T2 disease were included in their studies. In agreement with other authors, 6 survival in our series was influenced mainly by the recurrent and not the initial tumor stage. Although there was a considerably large subgroup of patients with small initial tumors that could not be controlled by radiotherapy, partial laryngectomy as a salvage procedure was seldom possible because of tumor progression ending in more advanced recurrent tumor stages.…”

Salvage surgery for locally recurrent oropharyngeal cancer

“…Although we did not identify a difference in survival based on T classification, other retrospective series have reported that early‐stage locally recurrent tumors (ie, rT1 and rT2 tumors) have better survival . Other authors have found margin status to be one of the most important factors in predicting recurrence . We did find an association between margin status and RFS when comparing negative margins to close/positive margins ( p = .039).…”

“…14,16,22 Other authors have found margin status to be one of the most important factors in predicting recurrence. 13,16,30 We did find an association between margin status and RFS when comparing negative margins to close/positive margins (p 5 .039). Additionally, we observed that all patients with positive margins recurred within 2 years (all but 1 patient within 7 months).…”

Salvage surgery after radical accelerated radiotherapy with concomitant boost technique for head and neck carcinomas

“…The feasibility of salvage surgery depends on not only the location of the recurrence but also its extent and the type of surgery that can be attempted. Previous studies reported that the proportion of patients eligible for salvage surgery ranged between 34% and 75%, with patients with laryngeal cancers being the most often and most successfully salvaged 3–5, 11–13. In our series, all patients with laryngeal recurrences were operated on, whereas less than one quarter of the patients with recurrences in other locations were able to have salvage surgery.…”