Surgical resection of a solitary liver metastasis in a 46‐year‐old patient with a malignant thymoma

Marasco, William J.; Hergreuter, Charles A.; Pritchard, Elaine; O’Hara, Carl; Steele, Glenn

doi:10.1002/jso.2930460213

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…In addition, some cases of hematogenous metastasis in the liver have been reported. 3 However, to our knowledge, the present report is the fi rst one that describes direct invasion of thymoma to the liver. Strobel et al 4 recently reported that, although the 5-year survival rate of stage IV thymoma was similar to that of stage III (85% and 88%), the 10-year survival rate dropped to 47%.…”

Section: Discussionmentioning

confidence: 83%

Hepatic lesion of invasive thymoma: possibility of direct invasion

et al. 2007

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Thymomas grow slowly but tend to invade the surrounding tissue. We herein report four patients with hepatic lesions of thymomas, which were thought to have directly invaded the liver. These patients had received combined modality treatments throughout the clinical course, and the hepatic lesions appeared a long time after the initial treatment - 11.8 years on average. In these patients, the prognoses after the appearance of hepatic invasion were poor. Appropriate local control in the early stages of the clinical course may therefore be essential for preventing the extrathoracic spread of invasive thymoma.

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Section: Discussionmentioning

confidence: 83%

Hepatic lesion of invasive thymoma: possibility of direct invasion

et al. 2007

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“…16 Reviewing the English literature identified fifteen cases of metastatic thymoma to the liver, 7,[16][17][18][19][20][21][22] but only in six cases was the liver the only site of extrathoracic recurrence; and detailed information was only available for four cases. 17,[19][20][21] Three case reports described metachronous single liver metastases after primary resection of the thymoma; [19][20][21] and a fourth report described a case of multiple metastatic thymoma to the liver (Table 2). 17 Neoadjuvant chemotherapy was administrated and it resulted in regression of the primary lesion, which was completely resected, and one persistent hepatic nodule was treated with radiofrequency ablation.…”

Section: Discussionmentioning

confidence: 99%

Thymoma metastatic to liver and pancreas: case report and review of the literature

et al. 2017

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A 71-year-old man presented with a thymic mass involving the superior vena cava. A mediastinoscopical biopsy initially suggested a diagnosis of type A thymoma. After neoadjuvant chemotherapy, the patient underwent en-bloc thymectomy and vascular resection for a pathology-confirmed type B3 thymoma involving the superior vena cava, the left brachiocephalic vein and the distal part of the right brachiocephalic vein. Adjuvant radiotherapy was administered. Two years after the primary surgery, abdominal computed tomography (CT) and whole body fluorodeoxyglucose (18-FDG) positron emission tomography (PET) scans showed a single hepatic lesion that was treated with wedge liver resection. Pathological examination confirmed metastatic type B3 thymoma. Almost 4 years later, abdominal CT and 18-FDG PET revealed a 2.9-cm solid mass involving the body of the pancreas. Distal pancreatectomy with lymph node dissection was performed. Pathological examination showed a pancreatic metastasis from a type B3 thymoma, without lymph node involvement. The patient is alive and free of disease 6 months after the pancreatectomy (68 months after the initial thymectomy surgery). Intra-abdominal recurrence and pancreatic metastases are very uncommon manifestations of thymoma, but this event should be kept in mind when an abdominal mass is seen during follow-up.

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