Surgical Resection for recurrence after two-stage hepatectomy for colorectal liver metastases is feasible, safe and improves survival

Dealing with an insufficient future liver remnant: Portal vein embolization and two‐stage hepatectomy

“…Repeat surgery for recurrence after two-stage hepatectomy Recurrence after two-stage hepatectomy is frequent because this approach is typically used for patients with multiple and bilateral CLMs 25,27,[34][35][36][37][38][39][40][41][42]. Two studies have focused on the prognosis of recurrence after two-stage hepatectomy 91,92. Imai et al reported that 38 patients (61%) underwent repeat surgery for recurrence after two-stage hepatectomy and patients who underwent repeat surgery had better OS than patients who did not (46% vs 26%, P = 0.004).…”

“…Imai et al reported that 38 patients (61%) underwent repeat surgery for recurrence after two-stage hepatectomy and patients who underwent repeat surgery had better OS than patients who did not (46% vs 26%, P = 0.004). Lillemoe et al92 reported that 31 patients (37%) underwent resection for recurrence. RAS mutation and first recurrence in multiple sites were associated with worse survival.…”