Surgical Resection for Pulmonary Carcinoid: Long-Term Results of Multicentric Study—The Importance of Pathological N Status, More Than We Thought

Cusumano, Giacomo; Fournel, Ludovic; Strano, Salvatore; Damotte, Diane; Charpentier, Marie Christine; Galia, Antonio; Terminella, Alberto; Nicolosi, Maria Luisa; Regnard, Jean François; Alifano, Marco

doi:10.1007/s00408-017-0056-8

Cited by 32 publications

(37 citation statements)

References 30 publications

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“…The shorter m-TTR observed in patients with AC compared with TC (3 and 4.5 years, respectively) and recurrence time distribution (around 50% of recurrences happened after 5 years) was in line with other reports (6,21,23,33,34).…”

Section: Discussionsupporting

confidence: 91%

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A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors

et al. 2018

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Section: Discussionsupporting

confidence: 91%

“…Several reasons may explain this including different biology of the disease and different follow-up. Therefore, we think that nodal metastases should be confirmed as one of the most important prognostic factors (9,13,(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors

et al. 2018

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“…As expected and shown earlier, atypical histology, hilar/ mediastinal lymph node involvement at the time of diagnosis, and the presence of metastatic disease are associated with a worse outcome [10,12,13,17,26]. Previous reports have also pointed out the importance of the Ki-67 proliferation index as a prognostic factor [27][28][29][30].…”

Section: Discussionsupporting

confidence: 73%

“…The primary treatment for PC tumours is surgery [9]. In general, their prognosis is favourable, especially when resected, with a 5-year survival rate of more than 90%, but 10-20% of the tumours metastasize resulting in a lower survival rate [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research

et al. 2019

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Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be coupled with patients' clinical follow-up data and the data retrieved from national health registries. We collected a nationwide pulmonary carcinoid tumour series from Finnish biobanks to study prognostic factors as well as to explore how the number of tumours found in the Finnish biobanks corresponds to the number of tumours registered by the Finnish Cancer Registry (FCR). Finnish biobanks identified 88% of the tumours registered by the FCR and were able to deliver 63%. The main reasons for lacking samples were paucity of resected primary tumour tissue, incompatible primary diagnosis, and the absence of tissue blocks in the archives. The main bottleneck in the sample application process was retrieving patient data. Altogether, we received 224 tumour samples with appropriate patient data and identified six prognostic factors for shorter disease-specific survival: age over 56 years at the time of diagnosis, tumour size over 2.5 cm, atypical histology, Ki-67 proliferation index higher than 2.5%, hilar/mediastinal lymph node involvement at the time of diagnosis, and the presence of metastatic disease. In conclusion, the Finnish biobank infrastructure offers excellent opportunities for tissue-based research. However, to be able to develop the biobank operations further, involving more medical knowledge in the sample and data acquisition process is a necessity. Also, when working with tissue samples collected over decades, histological expertise is essential for re-evaluation and re-classification of the samples.

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“…High tumour proliferation is also associated with shorter survival, but the current grading system’s cut-off used for gastrointestinal NENs between G1 and 2 (Ki-67 > 3%) fails to reliably predict the disease outcome in terms of OS [6]. Other reported prognostic factors include TNM stage, primary tumour size and nodal metastases [3, 7, 8]. …”

Section: Introductionmentioning

confidence: 99%

Lung Carcinoids: Long-Term Surgical Results and the Lack of Prognostic Value of Somatostatin Receptors and Other Novel Immunohistochemical Markers

Daskalakis¹,

Kaltsas²,

Öberg³

et al. 2018

Neuroendocrinology

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Background/Aims: Lung carcinoids (LCs) are often diagnosed at an early stage and surgical intervention becomes the next phase of treatment. To date, there is lack of long-term follow-up data after surgery and prognostication based on WHO classification criteria and evolving prognostic markers, particularly the expression of somatostatin receptors (SSR). Methods: We included 102 consecutive patients (72 women; age at baseline 51 ± 16 years [mean ± SD]) with LCs, who underwent thoracic surgery (n = 99) and/or laser treatment (n = 8). Hospital charts were reviewed for clinico-pathological parameters. Immunohistochemical (IHC) expression of SSR1–5 and other novel markers were studied with regard to their prognostic value. Results: Five- and 10-year overall survival (OS) was 96 and 83% respectively; relative survival (RS) was 101 and 93% respectively; and event-free survival (EFS) was 80 and 67% respectively. Independent prognostic factors for OS, RS and/or EFS were age at diagnosis, histopathological type and the presence of ipsilateral mediastinal subcarinal lymph node metastases. Macro-radicality of resective surgery and its extent were associated with increased OS and EFS. The IHC expression of SSR1–5 and other novel markers was not associated with OS or EFS. Conclusion: The long-term outcome of surgically treated patients with LCs is favourable. Age, histopathological type and ipsilateral mediastinal subcarinal lymph node status at baseline were independent prognostic factors for survival and disease recurrence or progression. The extent of surgery and operative macro-radicality also had an impact on prognosis. None of the IHC markers tested appeared to be associated with disease prognosis.

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Surgical Resection for Pulmonary Carcinoid: Long-Term Results of Multicentric Study—The Importance of Pathological N Status, More Than We Thought

Abstract: Surgery for lung carcinoids allows satisfactory oncological results which mainly depend on carcinoid subtype dichotomy, pathological nodal status, and SUV.

Cited by 32 publications

References 30 publications

A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors

A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors

Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research

Lung Carcinoids: Long-Term Surgical Results and the Lack of Prognostic Value of Somatostatin Receptors and Other Novel Immunohistochemical Markers

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