Surgical Resection and Liposomal Amphotericin B to Treat Cavitary Pulmonary Zygomycosis in a Patient With Diabetes

Zhu, Hongwei; Liang, Jian; Gao, Jie; Mo, Guoxin; Jia, Yuhua; Xie, Lei

doi:10.4187/respcare.01119

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Pulmonary mucormycosis is a rapidly fatal illness that typically develops in patients with profound neutropenia and graft-versus-host disease [2,3], with an overall mortality rate of 76%, which increases to 95% after extrathoracic dissemination [4][5][6][7][8][9][10]. Combined surgical/medical treatment may provide a better survival outcome in pulmonary mucormycosis compared to medical therapy alone [11].…”

Section: Introductionmentioning

confidence: 99%

IFN-γ mediated signaling improves fungal clearance in experimental pulmonary mucormycosis.

Santos

Fraga-Silva

Donanzam

et al. 2021

Preprint

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We established three immunocompetent murine models of pulmonary mucormycosis to determine the involvement of the adaptive immune response in host resistance in pulmonary mucormycosis, a rapidly fatal disease caused mainly by Rhizopus spp. Immunocompetent BALB/c, C57BL/6, and Swiss mice were inoculated with R. oryzae via the intratracheal route. The inoculation resulted in an angioinvasive infection that spread to the brain, spleen, kidney, and liver. After 7 and 30 days of R. oryzae infection, C57BL/6 and BALB/c mice showed the lowest fungal load and highest production of IFN-γ and IL-2 by splenocytes, respectively. Swiss mice showed a higher fungal load 30 days p.i. and was associated with a weak development of the Th-1 profile. To confirm our findings, R. oryzae-infected IFN-γ-/- mice were evaluated after 60 days, where the mice still showed viable fungi in the lungs. This study showed, for the first time, that pulmonary mucormycosis in three widely used mouse strains resulted in an acute fungal dissemination without immunosuppression whose outcome varies according to the genetic background of the mice . We also identified the partial role of IFN-γ in the efficient elimination of R. oryzae during pulmonary infection.

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Section: Introductionmentioning

confidence: 99%

IFN-γ mediated signaling improves fungal clearance in experimental pulmonary mucormycosis.

Santos

Fraga-Silva

Donanzam

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The outcome is typically fatal when pulmonary mucormycosis develops in a patient with hematological disease ( 41 ). Combined surgical/medical treatment may provide a better survival outcome than medical therapy alone ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary mucormycosis: A case report and review of the literature

et al. 2016

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The current study reports the case of a 15-year-old male who presented to The First Affiliated Hospital of Soochow University (Suzhou, Jiangsu, China) with a 3-day history of anergy and epistaxis. The patient was diagnosed with T-cell acute lymphoblastic leukemia according to the results of a bone marrow examination and received chemotherapy. During the agranulocytosis period, the patient developed pneumonia of the right upper lung (RUL). Once complete remission was achieved, the patient underwent a lobectomy of the RUL, together with amphotericin B therapy, following the confirmation of pulmonary mucormycosis by the histopathological results. The patient experienced 12 months of uneventful follow-up post-surgery.

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“…Pulmonary mucormycosis is a rapidly fatal illness that typically develops in patients with profound neutropenia and graft-versus-host disease [6,7], with an overall mortality rate of 76%, which increases to 95% after extrathoracic dissemination [8][9][10][11][12][13][14]. Combined surgical/medical treatment may provide a better survival outcome in pulmonary mucormycosis compared to medical therapy alone [15].…”

Section: Introductionmentioning

confidence: 99%

IFN-γ Mediated Signaling Improves Fungal Clearance in Experimental Pulmonary Mucormycosis

et al. 2021

View full text Add to dashboard Cite

Surgical Resection and Liposomal Amphotericin B to Treat Cavitary Pulmonary Zygomycosis in a Patient With Diabetes

Cited by 4 publications

References 11 publications

IFN-γ mediated signaling improves fungal clearance in experimental pulmonary mucormycosis.

IFN-γ mediated signaling improves fungal clearance in experimental pulmonary mucormycosis.

Pulmonary mucormycosis: A case report and review of the literature

IFN-γ Mediated Signaling Improves Fungal Clearance in Experimental Pulmonary Mucormycosis

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