Surgical Resection and Adjunctive lmmunotherapy for Selected Patients with Multiple Pulmonary Metastases

Morton, Donald L.; Joseph, William L.; Ketcham, Alfred S.; Geelhoed, Glenn W.; Adkins, Paul C.

doi:10.1097/00000658-197309000-00016

Cited by 138 publications

(31 citation statements)

References 16 publications

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“…In the modern era of surgery the intentional resection of a pulmonary metastasis gained some favor thanks to the pioneering work of Barney and Churchill in 1939 [5] and Alezander and Haight in 1947 [6] until more recent series published good results even in patients with multiple bilateral metastases [7][8][9] (Fig. 2).…”

Section: Discussionmentioning

confidence: 99%

Which factors affect pulmonary function after lung metastasectomy?☆

Petrella

Chieco²,

Solli

et al. 2009

European Journal of Cardio-Thoracic Surgery

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Background: Pulmonary metastasectomy is an accepted procedure in selected patients, very often requiring multiple non-anatomical resections. Although it is intuitive that functional loss is proportional to the number and extent of pulmonary resections, this link has never been proved and is the hypothesis behind this study. Methods: We retrospectively reviewed pulmonary function changes after lung metastasectomy. Baseline and postoperative spirometric values were evaluated and their changes were correlated to (a) number of resections, (b) extent of resections and (c) intervals between surgery. Results: Sixty-six patients were enrolled (31 men, mean age 56 years, range: 23-75); mean interval between surgery: 54.5 days; mean extent of resection: 11.45 cm; mean number of resections: 3. Preoperative mean spirometric values were: FEV1 2.73 l (97.75%); FVC 3.11 l (95.50%); DLCO/AV 1.21 l (99.80%). Mean changes in FEV1, FCV and DLCO/AV were À13.4%, À12.4% and +1.2% respectively. Patients receiving three or more non-anatomical resections had functional loss similar to those undergoing lobectomy. The extent of total resection (>11 cm, p < 0.05) and the interval between surgery (>90 days, p < 0.0001) influenced FEV1 and FVC modifications. At three months none of these functional modifications remained. Sex, age, side of the operation and histology of primary tumor did not affect spirometric changes. Conclusions: Spirometric changes after pulmonary metastasectomy are affected by total volume lung parenchyma resected within the first 90 days. Functional loss after three or more non-anatomical resections is comparable to that recorded after lobectomy. #

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Section: Discussionmentioning

confidence: 99%

Which factors affect pulmonary function after lung metastasectomy?☆

Petrella

Chieco²,

Solli

et al. 2009

European Journal of Cardio-Thoracic Surgery

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“…using a well-described technique [19][20][21]. Briefly, successive chest radiographs were used to measure the changing diameters of each nodule.…”

Section: Tumor Doubling Timementioning

confidence: 99%

Tumor doubling time: A selection factor for pulmonary resection of metastatic melanoma

1998

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“…Growth rates in a variety of human cancers have been assessed in terms of metastatic regions observed in the lung and liver in serial roentgenographs and on computertomography [1][2][3], and this was reported to be of great advantage in predicting the subsequent course of the dis ease [2]. In prostate cancer, however, the most common metastatic lesion is in bone and the extent of this metasta bling time in untreated patients and those who have relapsed from radiation therapy and radical prostatecto my has recently been reported to be useful [8][9][10][11][12][13],…”

Section: Introductionmentioning

confidence: 99%