Surgical Resection Alone Is Effective Treatment for Ovarian Immature Teratoma in Children and Adolescents: A Report of the Pediatric Oncology Group and the Children’s Cancer Group

Cushing, Barbara; Giller, Roger; Ablin, Arthur R.; Cohen, Lewis; Cullen, John W.; Hawkins, Edith P.; Heifetz, Stephen A.; Krailo, Mark; Lauer, Stephen J.; Marina, Neyssa; Rao, Pasupuleti Visweswara; Rescorla, Frederick J.; Vinocur, Charles D.; Weetman, Robert M.; Castleberry, Robert P.

doi:10.1097/00006254-200001000-00016

Cited by 17 publications

(20 citation statements)

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“…[167][168][169][170] Observation or chemotherapy may be considered for children or adolescents with select stage IA or IB tumors (see LCOH-11; page 1145). 156,167,169,[171][172][173] For patients with stage II to IV malignant dysgerminomas or immature teratomas, postoperative chemotherapy is recommended (see OV-B, 4 of 7; page 1146).…”

Section: Malignant Germ Cell Tumorsmentioning

confidence: 99%

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Morgan

Armstrong

Alvarez

et al. 2016

J Natl Compr Canc Netw

299

233

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Section: Malignant Germ Cell Tumorsmentioning

confidence: 99%

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Morgan

Armstrong

Alvarez

et al. 2016

J Natl Compr Canc Netw

299

233

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“…However, Gadducci et al [9] advised surgery alone as treatment for the tumor of stage I, grade 2 and 3. In addition, Cushing et al [10] reported 31 cases of immature teratoma of grade 1-3 were found to have a 5-year survival of 97% after primary conservative therapy (surgical resec- …”

Section: Discussionmentioning

confidence: 99%

A case of pathologic fracture of the proximal femur resulting from metastatic bone tumor of ovarian immature teratoma

Kim

Choi

Sung

et al. 2012

Korean J Obstet Gynecol

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Composing of less than 1% of all ovarian cancers, immature teratoma is a malignancy that mainly affects the young. In this report, we present the first case of pathologic fracture of the proximal femur resulting from metastatic bone tumor of ovarian immature teratoma. A 33-year-old Korean female was diagnosed as immature teratoma of stage Ia and grade 3. Eleven months following initial surgery, she had developed right thigh pain and palpable mass, which was confirmed metastasis of immature teratoma. She had her right leg broken during concurrent chemoradiation. She took mass excision, closed reduction with internal fixation and allo-bone graft followed by 6 cycles of chemotherapy and 10 times of radiotherapy. Now she is on regular follow-up and remained disease-free for 14 months. Copyright © 2012. Korean Society of Obstetrics and GynecologyOvarian immature teratoma affects mostly young women and constitutes approximately 1% of all ovarian malignancies [1]. The symptoms are often nonspecific, usually consisting of mass effect inflicting abdominal or pelvic discomfort and this tumor is rapidly progressive without treatment [1,2]. Although it was previously regarded as having a high mortality rate, the concurrent chemotherapeutic agents, combination of bleomycin, etoposide, and cisplantin (BEP), gives rise to better survival while minimizing toxicity profile [1,3]. Distant metastasis of immature teratoma of the ovary is uncommon [4]. In this report, we present the first case of bone metastasis from immature teratoma of the ovary followed by pathologic fracture. Case ReportA 33-year-old female was diagnosed as ovarian immature teratoma with stage Ia, grade 3 following left ovarian cystectomy. She underwent staging laparotomy involving hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection and appendectomy. She did not receive adjuvant chemotherapy. Seven months following staging surgery, the patient revisited with complaints of right thigh pain and 4 × 3 cm sized palpable mass.

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“…In stage I malignant OGCT patients, a strategy of close clinical, radiological and serological surveillance after surgery can be considered, as suggested in the guidelines. However, it is important to recognize that the basis for this recommendation is largely from studies of younger patients [66][67][68][69][70][71]. In advanced disease, risk stratification using the testicular tumors' IGCCCG (International Germ Cell Cancer Collaboration Group) system might identify patients who could benefit from more intensive first-line chemotherapy.…”

Section: Chemotherapymentioning

confidence: 99%

Systemic management of malignant ovarian germ cell tumors in older women: two case reports and a review of the literature

Luís

Boussios

Dumas

et al. 2016

CBN

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Background Ovarian germ cell tumors (OGCT) account for 2-5% of ovarian malignancies, with an annual incidence of 0.5-1:100,000, typically occurring in young women. Yolk sac tumor (YST) is the second most common type of OGCT and has an aggressive phenotype. The rarity of this pathology in postmenopausal women poses challenges in the diagnosis and treatment. Patients and Methods We report two clinical cases of YST in postmenopausal women treated at the Royal Marsden and discuss diagnosis and treatment issues of OGCTs in older women. A literature review was also performed, which identified thirty-nine cases, including the two reported in this article. Results and ConclusionThis showed that YSTs in older women are rare and are generally aggressive with poor clinical outcomes. Twelve of the described patients with malignant OGCTs died within 8 months of diagnosis.In conclusion, YST in postmenopausal women can have an aggressive disease course compared with younger patients. More evidence for the tolerability and outcomes of cytoreductive surgical approaches and intensive chemotherapy regimens in older patients is required.

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Surgical Resection Alone Is Effective Treatment for Ovarian Immature Teratoma in Children and Adolescents: A Report of the Pediatric Oncology Group and the Children’s Cancer Group

Cited by 17 publications

References 0 publications

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

A case of pathologic fracture of the proximal femur resulting from metastatic bone tumor of ovarian immature teratoma

Systemic management of malignant ovarian germ cell tumors in older women: two case reports and a review of the literature

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