Surgical removal of primary central nervous system lymphomas (PCNSL) presenting as space occupying lesions: a series of 33 cases

Bellinzona, Mattia; Röser, Florian; Ostertag, Helmut; Gaab, R.M.; Saini, Marco

doi:10.1016/j.ejso.2004.10.002

Cited by 141 publications

(84 citation statements)

References 27 publications

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“…The authors concluded that their data confirmed the role of RT and chemotherapy in the treatment of PCNSL reported previously, and that, although no benefit could be demonstrated for the role of sole surgical therapy, a selected subset of patients might benefit from craniotomy. The positive effect of surgical removal on survival could be seen among patients who received RT, chemotherapy or a combination of both, as well as all three treatment modalities had a positive and additive impact on survival (78). Of greatest significance, their data call into question the view that surgery plays a negative role in the treatment of PCNSL or that it gives no survival advantage in all cases (78).…”

Section: Surgical Considerationmentioning

confidence: 93%

“…The positive effect of surgical removal on survival could be seen among patients who received RT, chemotherapy or a combination of both, as well as all three treatment modalities had a positive and additive impact on survival (78). Of greatest significance, their data call into question the view that surgery plays a negative role in the treatment of PCNSL or that it gives no survival advantage in all cases (78).…”

Section: Surgical Considerationmentioning

confidence: 93%

“…Bellinzona et al (78) supported the use of craniotomy in a select subset of patients who present with large, solitary, space-occupying lesions and progressive neurological deterioration. The authors described 33 cases of PCNSL in 32 patients, among which 23 patients presented with clinical signs of high intracranial pressure.…”

Section: Surgical Considerationmentioning

confidence: 99%

See 2 more Smart Citations

Limited role of surgery in the management of primary central nervous system lymphoma (Review)

Cheng¹,

Zhang²,

Zhang³

et al. 2009

Oncol Rep

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Abstract. Primary central nervous system lymphoma (PCNSL) is a nervous-system-seeking extranodal nonHodgkin's lymphoma whose incidence has increased in both immunocompromised and immunocompetent patients. Corticosteroids are used for symptomatic management but can interfere with pathological diagnosis. The well-established treatments such as radiotherapy, chemotherapy or a combination of both remain the mainstays. Traditionally, the most important role for surgery is to obtain and sample adequate tissue to confirm a diagnosis with stereotactic biopsy. Though no benefit could be demonstrated for debulking surgery, a subset of patients with large space occupying lesions which could be well circumscribed and surgically accessible may benefit from tumor resection. Moreover, surgical procedures to carry out interstitial chemotherapy and/or brachytherapy with or without tumor resection hold promise. Complications such as hydrocephalus could be managed by ventriculoperitoneal shunting. Further application of surgical procedures in the treatment of PCNSL is recommended with caution and strict patient selection criteria, and should be used in combination with radiotherapy and/or chemotherapy.

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Section: Surgical Considerationmentioning

confidence: 93%

Section: Surgical Considerationmentioning

confidence: 93%

See 1 more Smart Citation

Limited role of surgery in the management of primary central nervous system lymphoma (Review)

Cheng¹,

Zhang²,

Zhang³

et al. 2009

Oncol Rep

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“…Nearly all primary CNS lymphomas in immunodeficient patients are associated with EBV or HIV infections. 1,5,6,7,8,9,10 Although our patient was did not have any of the clinical symptoms that would suggest immunodeficiency.…”

Section: Discussionmentioning

confidence: 99%

Primary intracerebral lymphoma: Case report

Eser

Şahin²,

Korkmaz³

et al. 2012

J Clin Exp Invest

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ÖZETBurada magnetic rezonans görüntüleme (MRG) bulguları ile yüksek dereceli glioma ile karışabilecek olan bir primer merkezi sinir sistemi lenfoması (PMSL) sunuyoruz. Primer merkezi sinir sistemi lenfoması nadir bir tümördür ve intracranial tümörlerin % 0.3-3'ünü oluşturur. Altmış bir yaşında kadın hasta kliniğimize ciddi baş ağrısı, kusma, sol hemiparezi ve geçici bilinç kaybı ile getirildi. Primer merkezi sinir sistemi lenfoması çeşitli biyolojik ve radyolojik özellikler gösterebilir. Burada PMSL'nin MRG bulgularının yüksek dereceli glioma ile karışmasını vurguladık.Anahtar kelimeler: Primer merkezi sinir sistemi lenfoması, yüksek dereceli glioma, B-hücre, tanı ABSTRACTWe describe a case of primary central nervous lymphoma (PCNSL) that may be confused with magnetic resonance imaging (MRI) findings of high grade glioma. Primary central nervous lymphoma is a rare tumour and it account for 0.3-3% of intracranial tumours. A 61 year's old woman was admitted to our clinic with a severe headache, vomiting, left hemiparesia and transient loss of consciousness. Primary central nervous lymphoma may show various biological and radiological characteristics. We herein emphasized being confused with MRI findings of PCNSL and high grade glioma. J Clin Exp Invest 2012; 3 (3): 409-411

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“…Surgical resection alone is generally considered ineffective as a therapeutic intervention and is associated with a median survival of 1-4 months. [11][12][13] Attempts at resecting PCNSL are associated with an increased risk for neurological complications without survival benefit in most reports. 14,15 In a subset analysis from 1 prospective randomized trial, there was a suggested benefit to surgical resection; however, the analysis was limited by probable selection bias.…”

Section: Clinical and Histologic Featuresmentioning

confidence: 99%

Management of primary central nervous system lymphoma in children

2016

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A 14-year-old boy with no significant past medical history presents with headaches and vomiting and is found to have a 2 × 3-cm left parietal lobe mass. A stereotactic biopsy reveals diffuse large B-cell lymphoma (DLBCL). Cerebrospinal fluid cytology, as well as bone marrow biopsies are negative, and a whole-body positron emission tomography/computed tomography scan does not demonstrate other areas of disease. The primary medical team asks how you would treat this patient.

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Surgical removal of primary central nervous system lymphomas (PCNSL) presenting as space occupying lesions: a series of 33 cases

Cited by 141 publications

References 27 publications

Limited role of surgery in the management of primary central nervous system lymphoma (Review)

Limited role of surgery in the management of primary central nervous system lymphoma (Review)

Primary intracerebral lymphoma: Case report

Management of primary central nervous system lymphoma in children

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