Surgical removal of adult recurrent neuroblastoma located in the posterior mediastinum and retroperitoneum

Ma, Xiang; Yang, Yunchuan; Wang, Zhaoying; Sun, Weili; Zhang, Dengyong; Wu, Bian; Wu, Hua; Cui, Peng

doi:10.1097/md.0000000000013642

Cited by 3 publications

References 19 publications

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Neuroblastoma in Adults: A Scoping Review of Presentations, Genetics and Therapies

Alsaikhan,

Alwahhabi,

Alshalan

et al. 2024

Preprint

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Purpose: As a scoping review, evaluate the literature on the presentations, genetics, and therapies for neuroblastoma in adult patients. Methods: We searched four databases for studies reporting adults with neuroblastoma. Cohort studies, case series, and case reports were synthesized qualitatively. Progression-free and overall survival were compared amongst cohort studies. Results: Of 2287 unique records, 136 studies published in 141 articles were included. A total of 679 patients were included. On review of individual patient-level data, the adrenal gland and retroperitoneum were the most common primary site (47.3%). MYCN was rarely amplified: seven studies reported zero patients with MYCN amplified, two studies with a single patient, and one study with 3/7 patients. Adult patients appear to show a high frequency of somatic mutations, specifically ALK (42%) and ATRX (58%). Registry data of included studies showed 5-year overall survival to be 36.3% in adults aged ≥20 years. Conclusion: Of nearly 700 cases of adult neuroblastoma published in the literature, the most common primary site is the adrenals or retroperitoneum. Relative to pediatric cases, adult cases demonstrate a considerable rate of somatic mutations such as ALK and ATRX. Registry data showed 5-year survival of 36%. Future studies evaluating targeted therapies in larger samples are needed.

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Neuroblastoma in Adults: A Scoping Review of Presentations, Genetics and Therapies

Alsaikhan,

Alwahhabi,

Alshalan

et al. 2024

Preprint

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Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

et al. 2020

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Background Ganglioneuromas (GNs) are extremely rare, slowly growing, benign tumors that can arise from Schwann cells, ganglion cells, and neuronal or fibrous tissues. Due to their origin from the sympathetic neural crest, they show neuroendocrine potential; however, most are reported to be hormonally inactive. Nevertheless, complete surgical removal is recommended for symptom control or for the prevention of potential malignant degeneration. Case Report A 30-year-old female was referred to our oncologic center due to a giant retroperitoneal and mediastinal mass detected in computed tomography (CT) scans. The initial symptoms were transient nausea, diarrhea, and crampy abdominal pain. There was a positive family history including 5 first- and second-degree relatives. Presurgical biopsy revealed a benign ganglioneuroma. Total resection (TR) of a 35 × 25 × 25 cm, 2550-g tumor was obtained successfully via laparotomy combined with thoracotomy and partial incision of the diaphragm. Histopathological analysis confirmed the diagnosis. Surgically challenging aspects were the bilateral tumor invasion from the retroperitoneum into the mediastinum through the aortic hiatus with the need of a bilateral 2-cavity procedure, as well as the tumor-related displacement of the abdominal aorta, the mesenteric vessels, and the inferior vena cava. Due to their anatomic course through the tumor mass, the lumbar aortic vessels needed to be partially resected. Postoperative functioning was excellent without any sign of neurologic deficit. Conclusion Here, we present the largest case of a TR of a GN with retroperitoneal and mediastinal expansion. On review of the literature, this is the largest reported GN resected and was performed safely. Additionally, we present the first systematic literature review for large GN (> 10 cm) as well as for resected tumors growing from the abdominal cavity into the thoracic cavity.

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Metastatic adult neuroblastoma with spontaneous tumor lysis syndrome

et al. 2020

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Neuroblastoma (NB) is a solid tumor of the sympathetic nervous system, most commonly found in childhood, standing for 7% of all pediatric malignancies. The incidence in adults is markedly smaller: 1 case per 10 million adults per year. We report the case of a previously healthy 27-year-old woman who started with lumbar pain, asthenia, and abdominal distension over the last month. A chest and abdomen tomography scan showed a huge mass in the upper left hemithorax and marked hepatomegaly. The diagnosis was confirmed by hepatic and lung biopsies. On day 4, after admission, the patient started chemotherapy. On the following days, she had severe vaginal bleeding, epistaxis, worsening of the hepatic function markers, refractory shock, and multiple organ dysfunction. She died on the twelfth day of admission. We also present a review of adult cases of NB reported in the past 5 years.

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Surgical removal of adult recurrent neuroblastoma located in the posterior mediastinum and retroperitoneum

Cited by 3 publications

References 19 publications

Neuroblastoma in Adults: A Scoping Review of Presentations, Genetics and Therapies

Neuroblastoma in Adults: A Scoping Review of Presentations, Genetics and Therapies

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

Metastatic adult neuroblastoma with spontaneous tumor lysis syndrome

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