“…We define high-risk keratoplasty as: increased risk for immune reactions as the only elevated risk factor (presence of three or four quadrants with deep vascularization, history of previous keratoplasty, or graft position close to the limbus), transplantation of a highly immunogenic graft (e.g., central limbo-keratoplasty [42]), severe atopic dermatitis, and steroid-response glaucoma (Table 2) (4,6,43,44). Exclusion criteria were herpetic keratitis or other infectious corneal diseases, because of the difficulties in differentiating an intraocular herpes recurrence from an immune reaction.…”