Surgical pathology of the liver in HIV infection

Wilkins, M.J.; Lindley, R; Dourakis, S.P.; Goldin, Robert

doi:10.1111/j.1365-2559.1991.tb00878.x

Cited by 49 publications

(15 citation statements)

References 20 publications

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“…NHL of the liver is a relatively frequent tumour in HIV infected patients. 2,4,7,8,19 All the subjects were within the fourth and fifth decades of their lives. Sclerosing cholangitis (AIDS-cholangiopathy) was reported in two (2%) of the patients.…”

Section: Discussionmentioning

confidence: 99%

Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria

Echejoh¹,

Mandong²,

Tanko³

et al. 2006

Trop Doct

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Multi-organ involvement by opportunistic infections and neoplasms is the major cause of morbidity and mortality in people living with HIV/AIDS. We determined the spectrum/frequency of hepatic histopathological lesions in a prospective study of postmortem liver biopsies from 100 patients (50 females and 50 males, age range 18-55 years) who died from HIV/AIDS in Jos university teaching hospital, Nigeria. The majority of the patients, 65 (65%), had clinical tuberculosis. Granulomatous hepatitis, chronic hepatitis, non-specific reactive hepatitis (NSRH) and steatosis were the commonest hepatic histopathologic lesions occurring in 34, 20,15 and 12% of patients, respectively. Seven (7%) had normal histological features. This study shows that the liver is affected in HIV/AIDS as reported elsewhere in the world. Therefore, liver biopsy in HIV patients may be helpful in the management of these patients.

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Section: Discussionmentioning

confidence: 99%

Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria

Echejoh¹,

Mandong²,

Tanko³

et al. 2006

Trop Doct

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show abstract

“…similar to that of aspergillosis. 33 The inflammatory reaction in Cryptococcus infection is variable and depends on the immune status of the host, ranging from a suppurative, necrotizing inflammatory reaction with granulomatous features, to virtually no reaction at all in immunocompromised hosts [36][37][38] (Figure 9). Purely granulomatous responses are sometimes seen.…”

Section: Selected Examples Of Hepatic Fungal Infections Featuring Gramentioning

confidence: 99%

Hepatic Granulomas: A Review With Emphasis on Infectious Causes

Lamps

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context Many diseases that cause granulomas or granulomatous inflammation involve the liver. Some of these disease processes are intrinsic hepatic diseases, whereas others are disseminated systemic diseases that involve the liver as well as other organs. Objective To review the evaluation of granulomas in the liver with an emphasis on infectious causes, as well as the use of special stains, serologic studies, and molecular diagnostic techniques. Pertinent noninfectious causes of hepatic granulomas that are in the differential diagnosis are also discussed. Data Sources Literature review and cases acquired during years of practice. Conclusions A wide variety of infectious and noninfectious entities cause hepatic granulomas.

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“…25 The inflammatory reaction in Cryptococcus is variable and depends on the immune status of the host, ranging from a suppurative, necrotizing inflammatory reaction with granulomatous features, to virtually no reaction at all in immunocompromised hosts. [28][29][30] Purely granulomatous responses are sometimes seen. Cryptococcosis may also involve the biliary tree.…”

Section: Hepatic Fungal Infections Featuring Granulomatous Inflammationmentioning

confidence: 99%

Hepatic Granulomas, With an Emphasis on Infectious Causes

Lamps¹

2008

Advances in Anatomic Pathology

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Granulomas are aggregates of macrophages, often admixed with other inflammatory cells, which usually result from chronic antigen presentation. Many diseases that produce granulomas involve the liver. Some are intrinsic hepatic diseases, whereas others are disseminated systemic diseases that involve the liver and other organs. Hepatic granulomas are reportedly present in 2% to 10% of all liver biopsy specimens examined in general practice, and of those supposedly as many as 36% have no discoverable etiology even after extensive evaluation of the specimen. This review focuses on the diagnosis of granulomas in infectious diseases affecting the liver, including use of special stains, serologic studies, and molecular diagnostic techniques, and discusses pertinent noninfectious causes of hepatic granulomas that are in the differential diagnosis.

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Surgical pathology of the liver in HIV infection

Cited by 49 publications

References 20 publications

Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria

Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria

Hepatic Granulomas: A Review With Emphasis on Infectious Causes

Hepatic Granulomas, With an Emphasis on Infectious Causes

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