Surgical–pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non–small cell lung cancer: A heterogeneous disease

Hsu, Chung-Ping; Hsia, Jiun-Yi; Chang, Gee‐Chen; Chuang, Chun‐Yi; Shai, Sen‐Ei; Yang, Shih-Chieh; Lee, Ming-Ching; Kwan, Po-Cheung

doi:10.1016/j.jtcvs.2008.12.035

Cited by 44 publications

(25 citation statements)

References 30 publications

(35 reference statements)

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“…ALI was a prognostic factor for OS, but not DFS, in our series, including elderly patients. Our findings are similar to those of previous studies [32, 33] that focused on patients with Stage I non-small cell lung cancer.…”

Section: Discussionsupporting

confidence: 92%

Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases

et al. 2017

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IntroductionPulmonary mucoepidermoid carcinoma is a rare cancer that occurs primarily in younger patients. The prognostic factors of pulmonary mucoepidermoid carcinoma are largely undetermined, especially in elderly patients. The aim of this study was to examine the clinical characteristics and prognostic factors influencing survival after surgical resection in patients with pulmonary mucoepidermoid carcinoma and also analyze the clinical manifestations and prognostic factors in elderly patients.Materials and methodsThe pathological records of 41 pulmonary mucoepidermoid carcinoma patients (mean age, 61.4 years) who underwent surgical resection at our hospital between January 1991 and July 2015 were retrospectively reviewed. Subjects >65 years of age (n = 22) were considered elderly.ResultsThe median follow-up duration was 42.9 (interquartile range, 15.0–120.8) months. Sixteen patients (39.0%) experienced tumor relapse, including 13 patients (81.3%) within 2 years. The 5-year disease-free survival rate was 57.9%. Tumor grade did not influence disease-free survival (P = 0.286). In the multivariate analysis, age, tumor size, pathological T3–4 status, and pathological N2 status were independent predictors of disease-free survival. The 5-year overall survival rate was 57.0%. Tumor grade also did not influence overall survival (P = 0.170). Age, tumor size, pathological T status, and pathological N2 status were independent predictors of overall survival. In elderly patients, the 5-year disease-free survival and overall survival rates were 41.4% and 41.5%, respectively. Pathological T status was the only independent predictor of both disease-free survival and overall survival in elderly patients.ConclusionsPrognostic factors identified for pulmonary mucoepidermoid carcinoma in this study differ from those of previous studies. Principally, tumor grade did not influence either disease-free survival or overall survival. Age, tumor size, and pathological factors were independent predictors of disease-free survival and overall survival. In elderly patients, pathological T status was the only independent predictor of disease-free survival and overall survival.

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Section: Discussionsupporting

confidence: 92%

Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases

et al. 2017

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“…In the prognosis of early-stage NSCLC, angiolymphatic invasion remains one of the most important poor indicators [18,22,23]. The presence of angiolymphatic invasion (ALI) can be detected by physical examination or by immunohistochemical staining for increased VEGF expression, which has a strong association with ALI [24].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, women have been noted to have improved outcomes in NSCLC, a trend that appears to be accentuated by the presence of TILs [23]. Whether the general increased overall and recurrence-free survivals are due to increased presence of TILs or a favorable histology in women is unclear.…”

Section: Discussionmentioning

confidence: 99%

Increased Levels of Tumor-Infiltrating Lymphocytes are Associated with Improved Recurrence-Free Survival in Stage 1A Non-Small-Cell Lung Cancer

Horne

Jack

Gray

et al. 2011

Journal of Surgical Research

112

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“…In the published literature, the impact of cell differentiation on survival was discussed primarily in patients with stage I NSCLC. HSU et al [28] reported that in NSCLC patients with stage Ib (pT2N0M0), cell differentiation is a significant prognosticator for overall survival (p50.0024). In a previous study, we also showed that cell differentiation was associated with overall survival in stage I NSCLC (p50.04) [29].…”

Section: Lung Cancer C-y Liu Et Almentioning

confidence: 99%

Prognostic factors in resected pathological N1-stage II nonsmall cell lung cancer

et al. 2012

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Stage II nonsmall cell lung cancer (NSCLC) has been redefined in the seventh edition of tumour, node, metastasis (TNM) classification for lung cancer. Stages IIa and IIb both contain node-negative (N0) and node-positive (N1) subgroups. The aim of this study was to evaluate the prognostic factors for overall survival in patients with resected N1-stage II NSCLC.Between January 1992 and December 2010, we retrospectively reviewed the clinicopathological characteristics of 163 N1-stage II (T1a-T2bN1M0) NSCLC in patients undergoing curative resection as primary treatment.Median follow-up time was 37.2 months. The 1-, 3-and 5-yr overall survival rates were 85.3%, 62.1% and 43.5%, respectively. Tumour involvement of the hilar/interlobar nodal zone and poorly differentiated histological grade were significant predictors for worse overall survival using multivariate analysis (p50.001 and p50.015, respectively). There were trends toward worse overall survival in older patients and those with larger tumour size (p50.063 and p50.075, respectively).In resected N1-stage II NSCLC, hilar/interlobar nodal involvement and poorly differentiated histological grade were significant predictors of worse overall survival. The differences in survival between these subgroups of patients may lead to the use of different adjuvant therapies or postsurgical follow-up strategies.

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Surgical–pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non–small cell lung cancer: A heterogeneous disease

Cited by 44 publications

References 30 publications

Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases

Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases

Increased Levels of Tumor-Infiltrating Lymphocytes are Associated with Improved Recurrence-Free Survival in Stage 1A Non-Small-Cell Lung Cancer

Prognostic factors in resected pathological N1-stage II nonsmall cell lung cancer

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