Surgical Palliation for Pancreatic Cancer

Singh, Surjait M.; Longmire, William P.; Reber, Howard A.

doi:10.1097/00000658-199008000-00003

Cited by 228 publications

(108 citation statements)

References 20 publications

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“…Because of the lower cost, hospitalization rate, and periprocedure morbidity, as well as the shorter length of hospital stay compared with surgical bypass, most patients are best palliated with stent placement [28][29][30]. Endoscopic stent placement has a higher success rate and lower 30-day mortality rate than percutaneous stenting and represents the procedure of choice [31].…”

Section: Obstructive Jaundicementioning

confidence: 99%

Metastatic Pancreatic Cancer: Emerging Strategies in Chemotherapy and Palliative Care

2003

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For these reasons, efforts at identifying and treating disease-related symptomatology are priorities. This update overviews symptom management, supportive care strategies, and both standard and emerging palliative chemotherapy options. The incorporation of molecularly targeted therapies into treatment of metastatic pancreatic cancer is reviewed as well. These strategies are of relevance to internists, gastroenterologists, oncologists, and other specialists who care for patients with pancreatic cancer.

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Section: Obstructive Jaundicementioning

confidence: 99%

Metastatic Pancreatic Cancer: Emerging Strategies in Chemotherapy and Palliative Care

2003

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“…Thus overall the majority of patients will have palliative treatment and therefore palliation of symptoms will still be an important focus. The three most important symptoms that should be treated in advanced pancreatic cancer are pain, duodenal obstruction and mainly obstructive jaundice which is present at the time of diagnosis in up to 90% of patients [11] [12]. The first biliary endoprosthesis was performed in 1979 [13].…”

Section: Discussionmentioning

confidence: 99%

Surgical Bypass versus Endoscopic Stenting for Unresectable Head Pancreatic Cancer, Which Palliative Treatment Is Better in Developing Countries, Morocco as an Example

Mazine¹,

Mohammed²,

Karima³

et al. 2017

OJGas

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Background: Metal stents for unresectable pancreatic cancer are associated with longer patency and superior cost-effectiveness. However, they are too expensive to be recommended routinely in developing countries. Moreover, a debate on outcome results in these patients who receive plastic biliary endoprothesis versus surgical bypass as palliation of obstructive jaundice. We aimed to compare retrospectively the outcomes in patients treated with plastic stent or surgical bypass as a palliative option for these patients. Patients and Methods: We have examined data for patients (n = 86) who received endoscopic stenting (n = 64) or surgical bypass (n = 22), from January 2013 to November 2016, as a palliative treatment for obstructive jaundice from inoperable cancer head pancreas. Results: Serum bilirubin and CA19.9 levels were comparable in age and gender matched patient groups. Moreover, post-operative major complications and 30-days mortality showed no significant differences among patient groups. However, surgical bypass treated patients showed longer initial hospital stay (9 vs. 6 days, p = 0.014), higher cost ($1600 vs. $1088) and longer survival (192 vs. 101 days, p = 0.003) compared to endoscopy-stenting treated patients. Re-hospitalization was required for 5 stented patients (averaged $448). Conclusion: Biliary bypass surgery for unresectable pancreatic cancer may improve patient survival, although prolongs hospital stay. It may be recommended for relatively fit patients with a life expectancy of 6 months and more.

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“…Carcinoma gall bladder was more common in comparison to the reports [Tom western countries [16-18J. Of the patients with carcinoma head of pancreas and carcinoma periampullary region, 17 to 90 per cent have jaundice as a result of biliary obstruction [19]. Surgical resection and reconstruction usually provide adequate biliary drainage, but only 10 to 20 per cent of patients can be treated surgically with an intention to cure [20].…”

Section: Discussionmentioning

confidence: 99%

An Experience in Management of Surgical Obstructive Jaundice

Kochar

Subhas

Chaubey

1996

Medical Journal Armed Forces India

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One hundred and five patients of surgical obstructive jaundice were admitted to Army Hospital, Delhi from July 1991 to June 1994. Patients were investigated as per the diagnostic protocol. The causes of obstruction were choledocholithiasis (24 patients), periampullary carcinoma and carcinoma head of pancreas (32 patients), carcinoma gall bladder and cholangiocarcinoma (11 patients each). The procedures performed to relieve obstructive jaundice in 89 cases included choledochojejunostomy (17), pancreato-duodenectomy (15), hepaticojejunostomy (15), choledocholithotomy (12) and choledochoduodenostomy (12). Mortality was 7 per cent in pancreatoduodenectomy and 8 per cent in palliative procedures. MJAFI 1996; 52 : 75-78

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Surgical Palliation for Pancreatic Cancer

Cited by 228 publications

References 20 publications

Metastatic Pancreatic Cancer: Emerging Strategies in Chemotherapy and Palliative Care

Metastatic Pancreatic Cancer: Emerging Strategies in Chemotherapy and Palliative Care

Surgical Bypass versus Endoscopic Stenting for Unresectable Head Pancreatic Cancer, Which Palliative Treatment Is Better in Developing Countries, Morocco as an Example

An Experience in Management of Surgical Obstructive Jaundice

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