Surgical pain control with ropivacaine by atomized delivery (spray): a randomized controlled trial

Collins, George E.; Gadzinski, J.; Fitzgerald, G.; Sheran, Jordan; Wagner, Sarah

doi:10.1016/j.fertnstert.2014.07.255

Fertility and Sterility

2014

DOI: 10.1016/j.fertnstert.2014.07.255

|View full text |Cite

Surgical pain control with ropivacaine by atomized delivery (spray): a randomized controlled trial

George E. Collins

J. Gadzinski

G. Fitzgerald

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…www.nature.com/scientificreports/ as well as shoulder-tip pain 6 . However, a few studies failed to show these beneficial effects of both trocar site local anesthesia 7 , and the intraperitoneal anesthesia 8,9 . A recent systematic review by Long et al 10 examined the evidence regarding the practice of preemptive analgesia administration; they reported that laparoscopic incisional infiltration has a modest effect, although data regarding this intervention are inconclusive.…”

mentioning

confidence: 99%

1206 The Effect of Sub-Cutaneous and Intra-Peritoneal Anesthesia on Post Laparoscopic Pain: A Randomized Controlled Trial

Gluck

Barber

Feldstein

et al. 2019

Journal of Minimally Invasive Gynecology

View full text Add to dashboard Cite

A few modes of perioperative local analgesia have been studied in order to reduce postoperative pain after laparoscopy, including preemptive local anesthetics in the trocar sites and intraperitoneal anesthetics administration at the end of the surgery. However, the evidence regarding their efficacy are conflicting. In addition, the combination of both aforementioned methods has been rarely studied. Our aim was to evaluate whether subcutaneous trocar site and/or intraperitoneal analgesia reduce pain after gynecologic operative laparoscopy. This was a single-centered, randomized, controlled, double-blinded trial. The patients were randomly assigned to one of four equally sized groups: group 1-subcutaneous and intraperitoneal analgesia; group 2-subcutaneous analgesia and intraperitoneal placebo; group 3-subcutaneous placebo and intraperitoneal analgesia; Group 4-subcutaneous and intraperitoneal placebo. The patients, the surgeons, and the pain evaluators were all blinded to the patient's allocation. Included were patients who underwent elective operative laparoscopy. Exclusion criteria were: active infection, pregnancy, known sensitivity to Bupivacaine-Hydrochloride, chronic pelvic pain, surgeries with additional vaginal procedures, conversion to laparotomy, and malignancy. A total of 9 ml of Bupivacaine-Hydrochloride (Marcaine) 0.5%, or Sodium-Chloride 0.9%, as a placebo, were injected subcutaneously to the trocar sites (3 ml to each trocar site), prior to skin incision. In addition, 10 ml of Bupivacaine-Hydrochloride 0.5%, diluted with 40 ml of Sodium-Chloride 0.9% (a total of 50 ml solution), or 50 ml of Sodium-Chloride 0.9%, as a placebo, were injected intraperitoneally at the end of the surgery. By utilizing the 10 cm Visual-analogue-scale (VAS) we assessed post-operative pain at rest at 3, 8, and 24 h, and during ambulation at 8 and 24 h. The study was approved by the local Institutional Review Board and has been registered at clinicaltrials.gov. We conformed to the CONSORT recommendations. Between December 2016 and July 2019, a total of 119 patients were included in the study. Demographic and interventional characteristics were similar among the groups. The level of postoperative pain, either at rest or with change of position, was not significantly different between the groups, at all-time points. Application of subcutaneous and/or intraperitoneal analgesia is not effective in reducing pain after gynecologic operative laparoscopy. Clinical trial identification number: NCT02976571. Date of trial registration 11/29/2016. URL of the registration site: https ://clini caltr ials.gov.One of the techniques for reducing pain and opiate demand after surgery is the use of local anesthesia in surgical incisions 1 . It has been shown that nociceptive stimuli can alter the electrophysiological processes in the neurons 2 . This alteration results in a lower pain threshold and an increased response to pain stimuli.By infiltrating a local anesthetic before the incision is made, these effects should in theory be avoided. Thi...

show abstract

mentioning

confidence: 99%

1206 The Effect of Sub-Cutaneous and Intra-Peritoneal Anesthesia on Post Laparoscopic Pain: A Randomized Controlled Trial

Gluck

Barber

Feldstein

et al. 2019

Journal of Minimally Invasive Gynecology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Surgical pain control with ropivacaine by atomized delivery (spray): a randomized controlled trial

Cited by 1 publication

References 0 publications

1206 The Effect of Sub-Cutaneous and Intra-Peritoneal Anesthesia on Post Laparoscopic Pain: A Randomized Controlled Trial

1206 The Effect of Sub-Cutaneous and Intra-Peritoneal Anesthesia on Post Laparoscopic Pain: A Randomized Controlled Trial

Contact Info

Product

Resources

About