for their continued support and outstanding leadership. The AJRA is committed to presenting the latest and highest quality clinical and translational research in the fields of rhinology, allergy, and skull base pathology. To that end, the March/April issue of the AJRA encompasses a broad spectrum of studies offering novel perspectives on a variety of allergy and rhinology related topics.Since its characterization, much knowledge has been gained regarding the multifaceted inflammatory nature of chronic rhinosinusitis (CRS), with both host (i.e., allergy, immunodeficiency, anatomic obstruction, etc.) and environmental factors (i.e., bacterial/viral infections, biofilms, pollutants, etc.) understood to be involved in its pathogenesis. 1 However, despite extensive research efforts, no clear etiology for CRS has been delineated. 1 In this issue, several studies aim to deepen our understanding of the complex pathophysiology of CRS and provide further insight into new treatment alternatives for this disease entity.On a molecular level, Lawrence et al investigate the effects of superoxide dismutase (SOD) on fungal antigen induced inflammatory responses in human sinonasal epithelial cells (HSNECs). 2 SOD treatment of HSNECs derived from CRS with nasal polyp patients attenuated inflammation triggered by Aspergillus and Alternaria, suggesting that SOD could be used as a potential therapeutic option for CRS in the future. 2 From a clinical aspect, Stevens and Peters examine how underlying immunodeficiencies may contribute to CRS. 3 In their review, multiple immune disorders (i.e., common variable immunodeficiency, selective IgA deficiency, and specific antibody deficiencies) are discussed including appropriate diagnosis, treatment, and impact on CRS. 3 Timely management of such immunodeficiencies with immunoglobulin replacement, etc. may have beneficial effects on the clinical course of CRS, particularly in patients with refractory disease. Likewise, Sedaghat and colleagues explore clustering patterns of CRS symptoms to determine correlations with demographic characteristics, comorbidities, and other objective findings. 4 Such unique associations indicate that distinct pathophysiologic processes may be responsible for specific CRS symptomatology.Endoscopic sinus surgery (ESS) plays an integral role in the surgical therapy of CRS, with well-documented benefits in both symptoms and quality of life (QOL). 5 However, local complications such as synechiae formation, middle turbinate lateralization, and mucosal edema can impede postoperative healing and ultimately compromise long-term surgical outcomes. 6,7 In their systematic review, Hobson and colleagues evaluate the utility of middle meatal packing in reducing the risk of scarring following ESS. 8 A meta-analysis of pooled data from eighteen randomized controlled trials was performed, which demonstrated a nonsignificant trend toward decreased adhesions in patients in whom middle meatal packing was placed. 8 Like ESS, endonasal endoscopic skull base surgery (EESBS) can also lead...