Surgical outcomes of patients with iridocorneal endothelial syndrome: a case series

İmamoğlu, Serhat; Sevim, Mehmet Şahin; Yıldız, Hatice Elvin; Vural, Ece Turan; Bardak, Handan; Bardak, Yavuz

doi:10.1007/s10792-016-0317-1

Cited by 11 publications

(8 citation statements)

References 21 publications

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“…The authors stated that the EX-PRESS mini-shunt appears to be safe for the management of ICE syndrome-related glaucoma and causes less postoperative inflammation than other drainage devices. 11 There are also other case reports regarding the successful management of uncontrolled IOP in ICE syndrome by implantation of EX-PRESS mini-shunt with adjunctive MMC, even up to 2 years after surgery. 16,17 With regards to the role of minimally invasive glaucoma surgery methods in ICE syndrome, there are also a few case reports that claim good IOP control was achieved with XEN gel stent (AqueSys Inc.) implantation.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of Trabeculectomy and Ahmed Glaucoma Valve Implantation in Patients With Iridocorneal Endothelial Syndrome

Nilforushan,

Abolfathzadeh,

Miraftabi

et al. 2024

Journal of Glaucoma

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Precis: Our study highlights the long-term success of trabeculectomy or AGV surgery in subjects with glaucoma secondary to ICE syndrome. However, many of ICE syndrome cases may need multiple glaucoma surgeries to achieve controlled IOP, with/without concomitant corneal graft surgery. Purpose: To evaluate the long-term outcome of trabeculectomy and Ahmed glaucoma valve (AGV) implantation in iridocorneal endothelial syndrome (ICE). Methods: Patients with glaucoma secondary to ICE syndrome who underwent either trabeculectomy or AGV surgery with intraoperative adjunctive MMC from 2009 to 2020 were included in this study. All patients were followed for at least 6 months after initial surgery. The main outcome measures were intraocular pressure (IOP), number of IOP lowering medications and surgical success. Surgical success was defined as complete according to the levels of IOP (<18) and at least 20% reduction from preoperative IOP without medications and qualified as complete success but with medications, where the number of medications was less than preoperative numbers. Cumulative success was the sum of the qualified and complete success. Results: Twenty-nine eyes of 29 patients were included. Trabeculectomy was done in 13 patients (group A, 44.8%) and 16 patients underwent AGV surgery (group B, 55.2%). The median age was 50(42-56.50) and 47(36.75-52.75) years in groups A and B, respectively (P value=0.10). All patients completed at least 2 years of follow up. Mean IOP was not significantly different between groups preoperatively (P=0.70) and the effect of the type of surgery on IOP was not statistically significant at multiple follow-up time points (repeated measures ANOVA, P=0.44). The mean IOP decreased from 35.76±6.36 mmHg preoperatively to 16.00+3.10 in group A and from 36.12+8.11 mmHg to 17.00+3.75 in group B (P=0.449) at year 2 of follow-up. The effect of the type of surgery was not significant on the total number of IOP lowering medications used throughout the study (repeated measures ANOVA, P=0.81). Kaplan-Meier analysis show complete success in 14 patients (48.3%), 11 patients (37.9%) and 7 patients (24.1%) at 6-month, 1 year and 2 years follow-up, respectively. Cumulative success rate was 95% at two years follow-up for all patients. Conclusions: In 2 year follow up, trabeculectomy or AGV could significantly reduce the IOP in glaucoma patients secondary to ICE syndrome.

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Section: Discussionmentioning

confidence: 99%

“…There are a limited number of published studies that report the long-term success rates and outcomes of primary trabeculectomy and/or glaucoma drainage devices (GDDs) with adjunctive MMC in cases of ICE syndrome. [4][5][6][7][8][9][10][11][12][13][14][15] However, the majority of these studies have relatively short follow-up periods.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Trabeculectomy and Ahmed Glaucoma Valve Implantation in Patients With Iridocorneal Endothelial Syndrome

Nilforushan,

Abolfathzadeh,

Miraftabi

et al. 2024

Journal of Glaucoma

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“…Although various filtrating procedures have been utilized in patients with GS-ICE, long-term surgical outcomes are still not satisfactory, mainly due to the sub-conjunctival fibrosis and synechia closure of the filtering ostium. 17,21,22 Angle closure is usually considered a contra-indication for minimally invasive trabecular bypass surgeries, such as trabectome and istent implantation, which makes the management of GS-ICE more challenging. Previously, we have successfully utilized the bleb-independent penetrating canaloplasty in primary angle closure glaucoma (PACG) with extensive PAS, providing evidence for the feasibility of IOP control through the physiological outflow pathway in eyes with angle closure.…”

Section: Discussionmentioning

confidence: 99%

Achieving Inner Aqueous Drain in Glaucoma Secondary to Iridocorneal Endothelial Syndrome: One Year Results of Penetrating Canaloplasty

Deng¹,

Zhang²,

Ye³

et al. 2022

American Journal of Ophthalmology

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“…Glaucoma drainage devices (GDDs) may create an alternate aqueous pathway from the anterior chamber by channeling aqueous out of the eye through a tube to a subconjunctival bleb or to the suprachoroidal space, thus bypassing the chief hazard of filtration procedures caused by the regrowth of an ICE membrane over the ostium for filtration and appearing to result in a higher success rate compared with trabeculectomy in ICE patients [13].…”

Section: Discussionmentioning

confidence: 99%

Surgical outcomes of Ahmed glaucoma valve implantation in patients with glaucoma secondary to iridocorneal endothelial syndrome

Mao

Guo²,

Zhong

et al. 2020

Eye

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Objectives To evaluate the long-term outcome of patients with iridocorneal endothelial (ICE) syndrome who underwent Ahmed glaucoma valve implantation surgery for uncontrolled glaucoma. Methods Eighteen patients who suffered from unilateral ICE syndrome with uncontrolled glaucoma and subsequently underwent Ahmed aqueous shunt surgery at Zhongshan Ophthalmic Center between January 2008 and December 2016 were reviewed. Outcome measures included intraocular pressure (IOP), the use of glaucoma medications, visual acuity, further surgical interventions, and surgical complications. Results The mean IOP was reduced from 34.8 ± 10.6 mmHg on 3.6 ± 0.5 medications to 17.4 ± 4.9 mmHg (t = 6.791, P = 0.000) on 1.6 ± 1.1 medications (Z = −3.545, P = 0.000) at the last follow-up (42.0 ± 19.3 months). Five eyes (27.8%) achieved complete success, nine (50.0%) achieved qualified success, and the remaining four (22.2%) were considered failures. Survival was 94.4% at 1 year, 88.1% at 2 years, and 73.5% at 3 years. Four cases displayed a flat anterior chamber and were treated with a single anterior chamber reformation surgery with no recurrence. No other complications related to the glaucoma drainage implants occurred in this series. Conclusions Ahmed glaucoma valve implantation appears to be a safe and effective method for treating glaucoma secondary to ICE syndrome. Postoperative shallow anterior chamber and hypotony may occur but responds well to the treatment. Early consideration may be given to aqueous shunt surgery in patients with glaucoma secondary to ICE syndrome when trabeculectomy fails.

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Surgical outcomes of patients with iridocorneal endothelial syndrome: a case series

Cited by 11 publications

References 21 publications

Outcomes of Trabeculectomy and Ahmed Glaucoma Valve Implantation in Patients With Iridocorneal Endothelial Syndrome

Outcomes of Trabeculectomy and Ahmed Glaucoma Valve Implantation in Patients With Iridocorneal Endothelial Syndrome

Achieving Inner Aqueous Drain in Glaucoma Secondary to Iridocorneal Endothelial Syndrome: One Year Results of Penetrating Canaloplasty

Surgical outcomes of Ahmed glaucoma valve implantation in patients with glaucoma secondary to iridocorneal endothelial syndrome

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