Surgical outcomes of pancreaticoduodenectomy in young patients: A case series

Abstract

PD in YA when performed in tertiary centers with good surgical experience is safe. The most common pathological diagnosis in the YA was adenocarcinoma followed by SPT.

Safety and Hazards of Middle-Life Robotic Pancreaticoduodenectomy

“…In a study of pancreaticoduodenectomy in a young population (≤30 years old), Mansfield et al [20] discovered that chronic pancreatitis (6, 27.3%) was the most common postoperative histologic diagnosis, followed by solid pseudopapillary tumors (22.7%) and adenocarcinomas (18.2%). A case series of young adults (less than 35 years) who underwent pancreaticoduodenectomy was described by El Nakeeb et al [1]. The results showed that adenocarcinoma (41.4%) was the most common pathological diagnosis in this cohort, followed by solid pseudopapillary tumors (29.3%).…”

“…The complex and challenging pancreaticoduodenectomy, sometimes called the "Whipple operation" is typically performed on elderly patients with pancreatic cancer and periampullary diseases. Younger patients are rarely given pancreaticoduodenectomy procedures, and the impact of age on surgical and survival outcomes is still unclear [1].…”

“…The influence of youth on surgical and survival outcomes following pancreaticoduodenectomy has not been thoroughly investigated, given its uncommon occurrence in younger patients. There is little literature in this field [1][2][3][4][5].…”

Modified duct-to-mucosa versus conventional pancreaticoenterostomy for pancreaticoduodenectomy: a retrospective cohort study based on propensity score matching analysis

“…PE is the committed step in the PD. Although some random studies and meta-analysis have been carried out, there is no evidence or guidelines on how to establish the best PE after PD [2–4, 6–8, 14, 15]. In recent 20 years, despite a significant decline in surgical mortality, the incidence of postoperative complications remains high (about 50%), and the incidence of serious complications of PD is relatively unchanged [16].…”

“…Among them, PE technique is the most crucial factor. To prevent pancreatic fistula, different types of surgical techniques to treat the residual end of the pancreas have been proposed [1–4, 6–8, 14, 15]. However, the efficacy of these techniques remains controversial, and no one is better than other methods [18].…”