Surgical outcomes in lung cancer presenting as ground-glass opacities of 3 cm or less: A review of 5 years' experience

Duann, Chi Wei; Hung, Jan Jong; Hsu, Po Kuei; Huang, Chien Sheng; Hsieh, Chih Cheng; Hsu, Han Shui; Wu, Yu Chung; Hsu, Wen Hu

doi:10.1016/j.jcma.2013.08.005

Cited by 19 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of a pure solid nodule independently predicted IAC with an AUC of 0.812, and patients with a pure solid nodule had a worse survival rate than did those with a pGGO or mGGO tumour. In agreement with our results, several studies found that the proportion of GGO areas relative to the total tumour area strongly predicted overall survival in patients with clinical T1N0M0 lung adenocarcinoma [29, 30]. Although our study shows that GGO is useful for diagnosing and predicting the prognosis of the adenocarcinoma subtypes, other factors should be identified to improve sensitivity and specificity, especially for mGGO tumours owing to their high recurrence rate [29].…”

Section: Discussionsupporting

confidence: 91%

Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

et al. 2016

View full text Add to dashboard Cite

Aims. Identification of factors that can predict the subtypes of lung adenocarcinoma preoperatively is important for selecting the appropriate surgical procedure and for predicting postoperative survival. Methods. We retrospectively evaluated 87 patients with lung adenocarcinomas ≤30 mm. Results. Preoperative radiological findings, serum CEA level, serum microRNA-183 (miR-183) level, and tumour size differed significantly between patients with adenocarcinoma in situ (AIS) or minimally invasive adenocarcinoma (MIA) and those with invasive adenocarcinoma (IAC). Receiver operating characteristic curves and univariate analysis revealed that patients who were older than 57 years or had a pure solid nodule or a tumour with mixed ground-glass opacity (mGGO), a tumour >11 mm, a serum CEA level >2.12 ng/mL, or a serum miR-183 level >1.233 (2−ΔΔCt) were more likely to be diagnosed with IAC than with AIS or MIA. The combination of all five factors had an area under the curve of 0.946, with a sensitivity of 89.13% and a specificity of 95.12%. Moreover, patients with a cut-off value >0.499 for the five-factor combination had poor overall survival. Conclusions. The five-factor combination enables clinicians to distinguish AIS or MIA from IAC, thereby aiding in selecting the appropriate treatment, and to predict the prognosis of lung adenocarcinoma patients.

show abstract

Section: Discussionsupporting

confidence: 91%

Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Six studies did not provide CT slice thickness while the remaining 21 studies reported CT slices from 0.5 to 3.0 mm. Time from the initial identification of the PSN to diagnosis and resection was given in only 1 of the 27 studies [57]. Tumour size was an inclusion criterion in all but two articles [56, 61].…”

Section: Resultsmentioning

confidence: 99%

“…Of the 20 listed groups, 13 reported DFS/RFS [54, 57, 59, 60, 64–66, 71, 72, 76, 78, 80, 81], 100% for 7 groups (345 patients) and ranged from 96.3% to 98.7% for another 6 groups (1507 patients). Among the 13 groups reporting OS [55–57, 59, 60, 63–65, 68, 69, 74, 78, 81], 2 (60 patients) reported an OS of 100% and 11 (1727 patients) reported OS rates ranging from 94.7% to 98.9%. One group of 23 patients had an LCS of 95.7% [55].…”

Section: Resultsmentioning

confidence: 99%

Controversies on lung cancers manifesting as part-solid nodules

Yip

Liu

et al. 2017

Eur Radiol

View full text Add to dashboard Cite

Purpose Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs). Methods PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs <80% or category PSNs ≥80%. Results Twenty studies reported on PSNs <80%: 7 reported DFS and 2 OS of 100%, 6 DFS 96.3-98.7%, and 11 OS 94.7-98.9% (median DFS 100% and OS 97.5%). Twenty-seven studies reported on PSNs ≥80%: 1 DFS and 2 OS of 100%, 19 DFS 48.0%-98.0% (median 82.6%), and 16 reported OS 43.0%-98.0% (median DFS 82.6%, OS 85.5%). Both DFS and OS were always higher for PSNs <80%. Conclusion A clear definition of the upper limit of solid component of a PSN is needed to avoid misclassification because cell-types and outcomes are different for PSN and solid nodules. The workup should be based on the size of the solid component.

show abstract

“…This group of tumors are correlated with a favorable prognosis after surgical resection. However, evidence suggests that other more invasive, non-lepidic growth patterns of adenocarcinoma such as acinar and papillary have presented as GGO nodules (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as ground glass opacity nodule

Moon¹,

Sung²,

Lee³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

Background: Ground glass opacity (GGO) generally associated with the lepidic component of lung adenocarcinoma. However, in some cases, GGO nodules have been associated with invasive adenocarcinomas, where a lepidic component is minimal or absent. The purpose of this study is to evaluate the clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as GGO nodules. Methods: We reviewed computed tomography (CT) images from 168 patients diagnosed with non-lepidic invasive adenocarcinoma classified as stage T1N0M0 (≤3 cm) who underwent curative anatomical resection.Tumors were classified according to radiologic features: 31 were GGO predominant (Group A) and 137 were solid predominant (Group B). The clinicopathological findings and recurrence free survival were used as outcome measures. Results: The mean percentages of micropapillary and solid component in tumor was higher in Group B than Group A (P<0.001) Pleural invasion and lymphatic invasion were more frequently seen in Group B.The presence of tumors with a micropapillary component was higher in Group B (P=0.040). The 3-year recurrence-free survival was lower in Group B than Group A (80.4% vs. 100%, P=0.019). Risk factors for recurrence such as presence of a micropapillary component and lymphatic invasion were more frequently seen in Group B. Conclusions: Non-lepidic invasive adenocarcinoma presenting as GGO has fewer risk factors and better prognosis when compared with those presenting as solid tumors. Therefore, the presence of GGO on chest CT is a good prognostic indicator for lung cancer irrespective of histomorphologic classification.

show abstract

Surgical outcomes in lung cancer presenting as ground-glass opacities of 3 cm or less: A review of 5 years' experience

Abstract: The percentage of malignancy is high in pulmonary GGOs. Surgery results in an excellent prognosis in these patients.

Cited by 19 publications

References 24 publications

Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma

Controversies on lung cancers manifesting as part-solid nodules

Clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as ground glass opacity nodule

Contact Info

Product

Resources

About