Surgical Outcomes in a Large, Clinical, Low-Dose Computed Tomographic Lung Cancer Screening Program

Walker, Bryan L.; Williamson, Christina; Regis, Shawn M.; McKee, Andrea B.; D’Agostino, Richard S.; Hesketh, Paul J.; Lamb, Carla; Flacke, Sebastian; Wald, Christoph; McKee, Brady

doi:10.1016/j.athoracsur.2015.04.112

Cited by 25 publications

(18 citation statements)

References 17 publications

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“…Alternatively-in the contemporary era of heightened vigilance, attention to patient safety, and documentation-it seems plausible that clinical events, including PSI, are being recorded more frequently, even if the actual rate has not risen. The temporal increase in composite rate of adverse events in our study directly contrasts findings from the thoracic surgery literature, which report improvements in near-and long-term clinical outcomes [41][42][43]. A previous analysis of all cancer surgeries in the Nationwide Inpatient Sample (NIS) database also found that reported hospital-acquired adverse events are increasing over time [44].…”

Section: Plos Onecontrasting

confidence: 55%

Increased reporting but decreased mortality associated with adverse events in patients undergoing lung cancer surgery: Competing forces in an era of heightened focus on care quality?

et al. 2020

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Introduction Advances in surgical techniques have improved clinical outcomes and decreased complications. At the same time, heightened attention to care quality has resulted in increased identification of hospital-acquired adverse events. We evaluated these divergent effects on the reported safety of lung cancer resection. Methods and materials We analyzed hospital-acquired adverse events in patients undergoing lung cancer resection using the National Hospital Discharge Survey (NHDS) database from 2001-2010. Demographics, diagnoses, and procedures data were abstracted using ICD-9 codes. We used the Agency for Healthcare Research and Quality (AHRQ) Patient Safety Indicators (PSI) to identify hospital-acquired adverse events. Weighted analyses were performed using t-tests and chi-square. Results A total of 302,444 hospitalizations for lung cancer resection and were included in the analysis.

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Section: Plos Onecontrasting

confidence: 55%

Increased reporting but decreased mortality associated with adverse events in patients undergoing lung cancer surgery: Competing forces in an era of heightened focus on care quality?

et al. 2020

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“…Other models have been described, including the use of a nurse navigator, 21,22 as well as an automated, structured reporting system that provides an optional or direct referral to a pulmonologist with any suspicious findings. 11,23,24 There are likely theoretic and institutional-level pros and cons to these approaches, but the financial impact of implementing these various programs within a health care system or subspecialty practice has not been previously reported.…”

Section: Discussionmentioning

confidence: 99%

“…Models for LCSP vary, and several have been reported [9][10][11][12] ; however, no comparative studies exist of these different models. The establishment of a centralized program with a focus on cigarette addiction and tobacco-related diseases, also incorporating incidental pulmonary nodules and lung cancer screening, may offer potential improvements in both the clinical and the financial impact of the program.…”

mentioning

confidence: 99%

The economic impact of a nurse practitioner–directed lung cancer screening, incidental pulmonary nodule, and tobacco-cessation clinic

Gilbert

Ely

Fathi

et al. 2018

The Journal of Thoracic and Cardiovascular Surgery

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A nurse practitioner-led program of lung cancer screening, incidental pulmonary nodules, and tobacco-cessation services can provide additional revenue opportunities for a Thoracic Surgery and Interventional Pulmonology Division, as well as a health care system. The current national, median annual wage of a nurse practitioner is $98,190, and the cost associated directly to their salary (and benefits) may remain neutral or negative within certain programs. However, the larger economic benefit may be realized within the division and institution. This potential additional revenue appears related to evaluation of newly identified diseases and subsequent evaluations, procedures, and operations.

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“…As we all know, lung cancer is the most common malignancy around the world [26]. The mortality of lung cancer is rather higher than that in the colorectal, gastric and breast cancer [27]. Almost 75% patients with lung cancer are diagnosed at the advanced stage due to the absence of obvious clinical symptoms [28].…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of miR-302b in Patients With NSCLC

Zhao

Kong

Wang

2020

Preprint

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Background: Lung cancer is the most common cancer worldwide. The most frequent type of lung cancer is non-small cell lung cancer (NSCLC). MicroRNAs (miRNAs) have been reported to play important role in human cancers. Studies suggest that the aberrant expression of miRNAs could act as the diagnostic or prognostic biomarker in human cancers, including lung cancer. MicroRNA-302b (miR-302b) has ever been investigated in several human cancers. The aim of this study was to examine the prognostic value of miR-302b in patients with NSCLC.Methods: Quantitative real-time RT-PCR (qRT-PCR) analysis were used to measure the expression level of miR-302b in NSCLC and adjacent noncancerous samples. The relationship of miR-302b with the clinicopathological data of NSCLC was analyzed by Chi-square test. The prognostic value of miR-302b was assessed by using the Kaplan-Meier survival curves and Cox regression analysis.Results: The expression level of miR-302b was downregulated in the NSCLC samples compared with the paired adjacent noncancerous samples (P < 0.05). The decreased miR-302b was found correlated with the differentiation (P = 0.019) and lymph node metastasis (P = 0.019) of NSCLC. The survival curves suggested that patients with lower miR-302b expression had poor overall survival than those with high miR-302b expression. The results of Cox analysis demonstrated that the expression of miR-302b was an independent and effective prognostic factor in NSCLC patients with the P of 0.002 (HR = 2.508, 95% CI = 1.410 - 4.463).Conclusion: In one word, the expression of miR-302b was decreased in NSCLC samples, and the miR-302 expression might act as a prognostic biomarker in NSCLC patients.

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Surgical Outcomes in a Large, Clinical, Low-Dose Computed Tomographic Lung Cancer Screening Program

Abstract: The incidence of surgical intervention for non-lung cancer diagnosis was low (0.30%) and is comparable to the rate reported in the National Lung Screening Trial (0.62%). Surgical intervention for benign disease was rare (0.24%) in our experience.

Cited by 25 publications

References 17 publications

Increased reporting but decreased mortality associated with adverse events in patients undergoing lung cancer surgery: Competing forces in an era of heightened focus on care quality?

Increased reporting but decreased mortality associated with adverse events in patients undergoing lung cancer surgery: Competing forces in an era of heightened focus on care quality?

The economic impact of a nurse practitioner–directed lung cancer screening, incidental pulmonary nodule, and tobacco-cessation clinic

The Prognostic Value of miR-302b in Patients With NSCLC

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