Surgical outcomes in 118 patients with Rathke cleft cysts

Aho, Christopher J.; Liu, Charles; Zelman, Vladimir; Couldwell, William T.; Weiss, Martin H.

doi:10.3171/jns.2005.102.2.0189

Cited by 210 publications

(336 citation statements)

References 18 publications

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“…Surgical intervention improves visual field defects in a considerable number of patients; in our study, 83% of the subjects with major visual field deficits showed improvement, a percentage comparable with other reports (59-100%) (5,7,12,14,16,20,21,23). In contrast to pituitary adenomas, and similarly to craniopharyngiomas (10), recovery of anterior pituitary hormone deficits following surgery is not common (5,12,14,16,20).…”

Section: Survival Function Censoredsupporting

confidence: 75%

“…In contrast to pituitary adenomas, and similarly to craniopharyngiomas (10), recovery of anterior pituitary hormone deficits following surgery is not common (5,12,14,16,20). In our study, apart from restoration of hypogonadism attributed to hyperprolactinaemia, we found no reversal of ACTH or TSH deficiency or of diabetes insipidus.…”

Section: Survival Function Censoredcontrasting

confidence: 47%

“…Nevertheless, the prognosis of RCCs following surgical intervention is more favourable than that of craniopharyngiomas (10), with reported relapse rates ranging widely between 0 and 42% during variable follow-up periods (4,5,(11)(12)(13)(14). It should be noted, however, that the published studies mainly involve small number of patients or short observation intervals, potentially compromising the practical clinical value of their results.…”

Section: Introductionmentioning

confidence: 83%

“…Major visual field defects were identified in 58% of the subjects. In previous studies, the frequency ranges between 38 and 49% (4,5,12,14,16,20,22) with the size of the cyst correlating with the presence of visual deterioration (20). At presentation, the reported rates of pituitary hormone deficits show wide variation (17-81%) also depending on the method of assessment (5,11,12,14,16,19,20,22,23).…”

Section: Discussionmentioning

confidence: 99%

“…Symptomatic RCCs are rare (4), and their clinical manifestations are associated with pressure effects on adjacent structures. Cyst evacuation combined with or without biopsy/removal of the cyst wall is the optimal management strategy for symptomatic cases (5)(6)(7)(8) resulting in improvement of headaches and the visual disturbances (5,7).…”

Section: Introductionmentioning

confidence: 99%

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Outcome in surgically treated Rathke's cleft cysts: long-term monitoring needed

Trifănescu¹,

Stavrinides²,

Plaha³

et al. 2011

European Journal of Endocrinology

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Objective: To clarify the outcome of all cases of Rathke's cleft cysts (RCC) treated surgically and followed up in Oxford during a long-term period. Subjects and methods: The records of all patients with RCC seen in the Department of Endocrinology between January 1978 and June 2009 were reviewed. Results: A total of 33 patients (20 females, median age 43 years) were identified. At presentation, major visual field defects were detected in 58% of patients and gonadotrophin, ACTH and TSH deficiency in 60, 36 and 36% of patients respectively. Desmopressin treatment was required in 18% of patients. Treatment consisted of cyst evacuation combined with or without biopsy/removal of the wall. Post-operatively, visual fields improved in 83% of patients with impairment, whereas there was no reversal of ACTH or TSH deficiency or of diabetes insipidus. All but one subject had imaging follow-up during a mean period of 48 months (range 2-267). Cyst relapse was detected in 22% of patients at a mean interval of 29 months (range 3-48 months); in 57% of them, the recurrence was symptomatic. Relapse-free rates were 88% at 24-months and 52% at 48-months follow-up. At last assessment, at least quadrantanopia was reported in 19% of patients, gonadotrophin, ACTH and TSH deficiency in 50, 42 and 47% of patients respectively. Desmopressin treatment was required in 39% of patients. Conclusions: In this study of patients with RCC and long-term follow-up, we showed a considerable relapse rate necessitating long-term monitoring. Surgical intervention is of major importance for the restoration of visual field defects, but it does not improve endocrine morbidity, which in the long-term affects a substantial number of patients.

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Section: Survival Function Censoredsupporting

confidence: 75%

Section: Survival Function Censoredcontrasting

confidence: 47%

Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Outcome in surgically treated Rathke's cleft cysts: long-term monitoring needed

Trifănescu¹,

Stavrinides²,

Plaha³

et al. 2011

European Journal of Endocrinology

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Rathke's Cleft Cysts

Han

Jahangiri

Aghi

2013

Pituitary Disorders

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Crush intraoperatory analysis in craniopharyngioma

Tena-Suck

Salinas-Lara

Vega-Orozco

et al. 2011

Diagnostic Cytopathology

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Intraoperative smear cytology provides a rapid and reliable intraoperative diagnosis and guidance to the neurosurgeon during surgical resection and lesion targeting. It also helps the surgeon to monitor and modify the approach at surgery. The aim of this article was a clinicopathological and cytomorphological intraoperative crush smear correlation in craniopharyngioma. Thirty craniopharyngiomas were included in this study. Twenty-seven cases were adaCP and only three cases were papCP. This series included 16 (53%) males and 14 (47%) females adult patients, aged from 15 to 86 years (median, 49 year). Two cases were frank errors, 12 cases showed partial correlation, 5 cases showed incomplete typing of the cell type, and 7 cases discrepancy in type of tumors. The percent error was 14%. Correlations with clinical details and radiological findings were helpful in improving the accuracy rate. Smear technique is a fairly accurate, relatively safe, rapid, simple, easily reproducible, and cost-effective tool to diagnose brain tumors. Smear cytology is of great value in intraoperative consultation of central nervous system pathology. The cytological aspects and smear patterns disclose important complementary diagnostic information for the histopathological examination.

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Surgical outcomes in 118 patients with Rathke cleft cysts

Cited by 210 publications

References 18 publications

Outcome in surgically treated Rathke's cleft cysts: long-term monitoring needed

Outcome in surgically treated Rathke's cleft cysts: long-term monitoring needed

Rathke's Cleft Cysts

Crush intraoperatory analysis in craniopharyngioma

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