Surgical Outcomes After Massive Subretinal Hemorrhage Secondary to Age-Related Macular Degeneration

Fine, Howard F; Iranmanesh, Reza; Priore, Lucian V. Del; Barile, Gaetano R.; Chang, L. L.; Chang, Stanley; Schiff, William M.

doi:10.1097/iae.0b013e3181e2263c

Cited by 46 publications

(47 citation statements)

References 32 publications

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“…Vitreous hemorrhage rates ranged from 0–67% [5,6,7,8,9,47], in group 3, to 0–38% [10,14,46] in group 4 (table 3). …”

Section: Resultsmentioning

confidence: 99%

“…Four other studies reported the combination of vitrectomy, subretinal rtPA application and air tamponade [7,8,9,46]; in one of these studies, intravitreal anti-VEGF agents were only administered postoperatively, if required by the study protocol [46]. Two studies administered subretinal rtPA combined with vitrectomy and gas tamponade [5,47]. Two studies retrospectively compared subretinal versus intravitreal rtPA administration, both combined with vitrectomy and gas injection [6,10]; patients in one of these two studies also received intravitreal anti-VEGF [10].…”

Section: Resultsmentioning

confidence: 99%

“…The range of retinal detachments was 0–45% in the less invasive group and 0–11% in the more invasive group. The percentage of vitreous hemorrhages ranged from 0–45% in the less invasive group (n = 724) [11,12,13,24,25,27,28,29,30,31,32,33,34,35,37,38,40,41,42,43,44,45] and from 0 to 67% in the more invasive group (n = 203, including 28 REH patients) [5,6,7,8,9,10,14,46,47 ](table 2). …”

Section: Resultsmentioning

confidence: 99%

“…Comparison of the complications between groups 3 (vitrectomy, subretinal rtPA, gas or air tamponade (n = 110)) [5,6,7,8,9,47] and 4 (vitrectomy, subretinal rtPA and anti-VEGF agents with gas or air tamponade (n = 93, including 28 REH patients)) [10,14,46], revealed that in group 3, the rate of recurrent submacular hemorrhage ranged from 0–27 versus 0–20% in group 4. Vitreous hemorrhage rates ranged from 0–67% [5,6,7,8,9,47], in group 3, to 0–38% [10,14,46] in group 4 (table 3).…”

Section: Resultsmentioning

confidence: 99%

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Literature Review of Recombinant Tissue Plasminogen Activator Used for Recent-Onset Submacular Hemorrhage Displacement in Age-Related Macular Degeneration

Zeeburg

Meurs

2012

Ophthalmologica

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Aims: To review and discuss the literature on recombinant tissue plasminogen activator (rtPA) for the treatment of a recent-onset submacular hemorrhage in patients with age-related macular degeneration. Methods: The administration technique of rtPA, the use of additional gas and vascular endothelial growth factor inhibitors (anti-VEGF), and the displacement rate of submacular hemorrhage and complications were noted from published reports, and a case series from the Rotterdam Eye Hospital (REH). Results: 38 studies with a total of 1,185 patients (1,176 eyes), and 28 patients from the REH were analyzed. Several methods for rtPA administration are available, which can be divided into two groups: submacular rtPA administration with vitrectomy; or intravitreal rtPA administration without vitrectomy. In both groups, the administration of gas and/or anti-VEGF agents could be additional. There appears to be no clear difference in complete displacement or complication rate between the more or the less invasive treatment groups. Conclusion: Although intravitreal injection of rtPA and gas only was reported to be as effective as subretinal rtPA with vitrectomy and gas, recent studies tend to use vitrectomy. These data underscore the need for a randomized controlled trial to choose the most effective and safe method of rtPA administration.

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“…Vitreous hemorrhage rates ranged from 0–67% [5,6,7,8,9,47], in group 3, to 0–38% [10,14,46] in group 4 (table 3). …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Literature Review of Recombinant Tissue Plasminogen Activator Used for Recent-Onset Submacular Hemorrhage Displacement in Age-Related Macular Degeneration

Zeeburg

Meurs

2012

Ophthalmologica

View full text Add to dashboard Cite

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“…MAIN OUTCOME MEASURES: Submacular hemorrhage displacement from the macula and changes in best-corrected visual acuities (BCVAs). RESULTS: Mean time from onset to surgery was 9.5 ± 4.5 (range, [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] days. Mean follow-up period was 9.4 ± 3.1 (range, [6][7][8][9][10][11][12][13][14][15][16][17] months.…”

mentioning

confidence: 99%