Surgical methods of focal hyaline cartilage defect management in large joints (literature review)

Airapetov, G.A.; Воротников, А. А.; Konovalov, E.A.

doi:10.18019/1028-4427-2017-23-4-485-491

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Сегодня предложено множество различных методов лечения, начиная от консервативных и заканчивая большими, агрессивными хирургическими вмешательствами [4][5][6]. Учитывая тот факт, что в медицинской литературе регулярно появляется информация о новых методах лечения заболеваний крупных суставов, можно сделать вывод о недостатках существующих.…”

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Optimal Choice of Animal for Experimental Work on Large Joints in Traumatology and Orthopedics (Literature Survey)

Airapetov¹,

Khurtuev²

2020

NMJ

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SCIENCE OF THE YOUNG (Eruditio uvenium). 2020;8(1):98-105 © Г.А. Айрапетов, А.Ж. Хуртуев _____________________________________________________________________________ Ставропольский государственный медицинский университет, Ставрополь, Российская Федерация _____________________________________________________________________________ Проблема заболеваний и повреждений крупных суставов является одной из самых актуальных в травматологии и ортопедии. Регулярно разрабатываются и внедряются новые, эффективные методы лечения. Для апробации новых технологий необходимо проведение экспериментальных исследований. Наиболее достоверными могут считаться результаты, полученные при использовании животных с выявлением патогенеза развития заболевания и механизмов его предотвращения. Для этих целей могут использоваться разнообразные животные. В работе проанализированы 30 источников литературы. Выполнялся анализ экспериментальных проспективных исследований и системных метаанализов. Данные литературы систематизированы и проанализированы. Установлено, что при планировании экспериментального исследования на крупных суставах животных необходимо учитывать сходство биохимических процессов и структур компонентов сустава с человеческим, а также возможность наблюдения за животным. Так, необходимо особое внимание уделять характеристикам нагрузки на сустав, от которых радикально меняются отдаленные результаты лечения. При моделировании экспериментальной работы связанной с внедрением нового метода хирургического лечения повреждений или заболеваний крупных суставов, предпочтительнее использовать крупных животных, таких как овцы. При изучении влияния консервативного лечения возможно использование мелких существ, таких как крысы или кролики. Ключевые слова: экспериментальное животное; экспериментальная модель; остеохондральный дефект; крупный сустав.

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Optimal Choice of Animal for Experimental Work on Large Joints in Traumatology and Orthopedics (Literature Survey)

Airapetov¹,

Khurtuev²

2020

NMJ

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Repair of Bone Defect of the Talus with Calcaneus Autograft and Autologous Matrix-Induced Chondrogenesis: A Case Report

Korobushkin,

Akhmedov,

Chebotarev

et al. 2023

Traumatology and Orthopedics of Russia

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Background. The question of choosing a treatment strategy for full-thickness osteochondral defects of the tarsal bone remains relevant. When choosing a treatment strategy, two key points should be considered: restoring the architecture of the tarsal bone and achieving long-term restoration of cartilage-like coverage in the area of the osteochondral defect. Case report. A 34-year-old physically active patient sustained an ankle injury in 2011 and was treated conservatively. In 2020, he complained of pain and reduced activity. Initial assessment scores were: VAS (Visual Analog Scale) — 6 points, AOFAS-AHS (American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Score) — 49 points, FAAM (Foot and Ankle Ability Measure) — 55 points. An MRI revealed an osteochondral defect in the medial part of the tarsal bone dome, measuring 16.4×9.4 mm and with a depth of 20.8 mm. The patient underwent the replacement of the bone defect with an autograft taken from the heel bone, using autologus matrix induced chondrogenesis (AMIC) procedure. After 6 months, a follow-up examination was performed, including ankle arthroscopy and removal of metal fixators. Arthroscopic findings showed that the chondroplasty area was almost identical to intact joint cartilage. One year after chondroplasty, the patient returned to his previous level of physical activity. Assessment scores were: VAS — 1 point, AOFAS-AHS — 94 points, FAAM — 83 points. Conclusion. The proposed method allows for the restoration of the architecture of the tarsal bone along with the cartilage surface. The use of a bone autograft helps to fill the tarsal bone defect, and covering the autograft with a collagen membrane contributes to the formation of hyaline-like cartilage tissue in the defect area.

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Technologies for stimulation of the reparative processes in children with knee osteochondritis dissecans: A review

Pligina

Kerimova²,

Burkin³

et al. 2022

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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Dissecting osteochondritis of the knee joint, Koenigs disease is a disease of the knee joint that result in articular surface and osteoarthritis congruence. The disease incidence reaches 15% in the pathological knee joint structure in children. The comparative effectiveness of various treatment methods for children with Koenigs disease, from conservative therapy to orthobiological technologies, is a topical subject of discussion among specialists. The effectiveness of modern treatment methods for children with Koenigs disease has been evaluated and is the leading trend in the use of biotechnology for further experimental and clinical studies. The literature search was conducted in the electronic databases of PubMed, Web of Science, Scopus, MEDLINE, eLibrary, RSCI, and Cyberleninka, whereas 2300 references were analyzed, 283 articles were viewed, and 90 publications on orthopedics and biotechnology were selected for the review. Indications for conservative treatment in children with Koenigs disease are currently limited to stages III of the process. Surgical methods occupy a dominant position when pain relief and pathological focus regeneration stimulation are necessary. However, the long-term results of therapy indicate the replacement of the necrosis zone with coarse fibrous connective tissue, which is significantly inferior to hyaline cartilage in terms of biomechanical characteristics, which determines a high risk of developing osteoarthritis. The actively developing direction of orthobiology allows the use of a patients tissues to activate the processes of reparative regeneration with the relief of clinical manifestations and favorable immediate results. The focus of attention of researchers has shifted to the plane of orthobiological technologies following the established trends in regenerative medicine development, which provide a high proportion of favorable immediate interventional results. However, the limited number of publications and the lack of long-term results of therapy do not meet the criteria for demonstrative effectiveness of technologies.

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Surgical methods of focal hyaline cartilage defect management in large joints (literature review)

Cited by 5 publications

References 33 publications

Optimal Choice of Animal for Experimental Work on Large Joints in Traumatology and Orthopedics (Literature Survey)

Optimal Choice of Animal for Experimental Work on Large Joints in Traumatology and Orthopedics (Literature Survey)

Repair of Bone Defect of the Talus with Calcaneus Autograft and Autologous Matrix-Induced Chondrogenesis: A Case Report

Technologies for stimulation of the reparative processes in children with knee osteochondritis dissecans: A review

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