Surgical management of thyroid cancer

Ramírez, Adonis; Gibelli, Bianca; Tradati, Nicoletta; Giugliano, Gioacchino; Zurlo, Valeria; Grosso, E; Chiesa, Fausto

doi:10.1586/14737140.7.9.1203

Cited by 21 publications

(26 citation statements)

References 106 publications

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“…Precise knowledge of the intricate anatomic details and meticulous surgical technique are prerequisite determinants for successful outcomes and to keep complications within acceptable limits. Ramirez et al 5 asserted that complications accompanying thyroid surgery are directly proportional to the extent of thyroidectomy and inversely proportional to the surgeon's experience.…”

Section: Introductionmentioning

confidence: 99%

Postoperative Complications of Thyroid Surgery: A Corroborative Study with an Overview of Evolution of Thyroid Surgery

Bansal¹,

Bhardwaj²,

Rathi³

et al. 2015

International Journal of Head and Neck Surgery

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Background:To study the frequency of postoperative complications after thyroid surgery indicated for various benign and malignant lesions and to corroborate the results in relation to the extent of surgery and a clinical overview of evolution of thyroid surgery. Materials and methods:An analytical study was carried out at a tertiary care center over a period of 3 years from January 2011 to December 2013. Data were collected from 80 patients who underwent thyroidectomies for various thyroid diseases at this center.Results: Hemithyroidectomy, isthmusectomy, subtotal, neartotal, and total thyroidectomies were performed in 36 (45%), 6 (7.5%), 8 (10%), 10 (12.5%), and 20 (25%) cases respectively. The overall postoperative complication rate was 20%. Postoperative hypocalcemia and recurrent laryngeal nerve injury were the most common complications. Permanent hypocalcemia and permanent recurrent laryngeal nerve injury were observed in 3.75 and 2.5% of all operated cases respectively. The less common complications were wound hematoma, seroma formation, and superior laryngeal nerve injury. There was no mortality observed in our series. Conclusion:The overall complication rate can be minimized by operating in a bloodless field, doing a meticulous dissection, and correctly identifying and preserving recurrent and superior laryngeal nerves along with parathyroid glands, if feasible.

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Section: Introductionmentioning

confidence: 99%

Postoperative Complications of Thyroid Surgery: A Corroborative Study with an Overview of Evolution of Thyroid Surgery

Bansal¹,

Bhardwaj²,

Rathi³

et al. 2015

International Journal of Head and Neck Surgery

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“…The surgical options of treatment for differentiated TC include total/near-total thyroidectomy, subtotal thyroidectomy, as well as lobectomy plus isthmusectomy [25]. In our study, there were 28 TC patients with a tumor of diameter 3 cm and they were treated by total/near-total thyroidectomy or subtotal thyroidectomy; among them, 7 cases by lymph node metastasis and 3 cases with pulmonary metastasis were treated by thyroidectomy.…”

Section: Methodsmentioning

confidence: 90%

The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)

Zheng

Wang

2017

World J Surg Onc

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BackgroundThis study aims at exploring the correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene and postoperative recurrence in patients with thyroid carcinoma (TC).MethodsA total of 312 patients diagnosed with TC were chosen for the study and categorized into recurrence (n = 75) and non-recurrence (n = 237) groups. The hTERT rs2736100 and rs2736098 polymorphisms were detected by performing polymerase chain reaction-restriction fragment length polymorphism. DNA methylation in the promoter region of hTERT gene was evaluated by pyrosequencing. A telephonic and/or outpatient follow-up was conducted for all patients. The correlations of DNA methylation and polymorphisms in the promoter region of hTERT with postoperative recurrence of TC patients underwent analysis.ResultsThe patient in the recurrence group showed evidently different pathological types and tumor stages in comparison to the non-recurrence group. The GG genotype of hTERT rs2736100 might increase the recurrence risk of TC patients. No correlations between hTERT rs2736098 polymorphisms and recurrence risk were observed. Compared to the TT + TG genotype frequency, the rs2736100 GG genotype frequency increased in patients without multicentricity, patients with extrathyroidal invasion, patients with lymph node metastasis, patients with undifferentiated carcinoma, and patients in the III + IV stage. The recurrence group showed significantly higher DNA methylation level compared to the non-recurrence group. The DNA methylation level was closely associated to tumor stage and lymph node metastasis of TC patients in the recurrence group.ConclusionsThe DNA methylation and rs2736100 polymorphisms in the promoter region of hTERT gene might be in correlation to postoperative recurrence of TC patients.

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“…The reasons for such finding are still unclear, since the complications associated with the thyroid surgery are inversely proportional to the surgeon's experience 5 . In the group which had them, there was a striking percentage of patients with postoperative compressive complaints.…”

Section: Discussionmentioning

confidence: 99%

Fatores que influenciam nas complicações das tireoidectomias

Neto

Tagliarini²,

López³

et al. 2012

Braz. j. otorhinolaryngol.

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T he postoperative outcome of thyroidectomies is related to factors concerning the patient, the thyroid disease, and the surgeon. Objectives:To analyze a clinic's experience with thyroidectomy complications. Study design: historical cross-sectional cohort study. Materials and Methods:We reviewed the charts from 228 patients submitted to thyroidectomy, between 1991 and 2004. Transient, permanent and total complications as well as persistence and recurrence of the basal disease were studied in relation to clinical and laboratory factors.Results: Total complications occurred in 34.65%, transient complications in 18.86% (9.21% had hypocalcemia, 0.44% had vocal cord paralysis), associated with the first postoperative years and pressure complaints, and permanent complications in 17.98% (8.77%: hypoparathyroidism; 1.75%: vocal cord paralysis), associated with malignancy and more radical surgeries. The thyroid disease persisted in 17.98% of the cases, associated with age and recurrence in 10.96%, associated with the first operative years, benign diseases and less radical surgeries. Conclusion:The complications were associated with pressure complaints, shorter complaining period, malignancy and more radical surgeries. The recurrence was associated with the first operative years, non-neoplastic thyroid diseases and less radical surgeries. The persistence of disease was associated with older age. Braz J Otorhinolaryngol. 2012;78(3):63-9. ORIGINAL ARTICLE BJORL

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Surgical management of thyroid cancer

Cited by 21 publications

References 106 publications

Postoperative Complications of Thyroid Surgery: A Corroborative Study with an Overview of Evolution of Thyroid Surgery

Postoperative Complications of Thyroid Surgery: A Corroborative Study with an Overview of Evolution of Thyroid Surgery

The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)

Fatores que influenciam nas complicações das tireoidectomias

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