Surgical management of the N0 neck in early stage T1–2 oral cancer; a personal perspective of early and late impalpable disease

Ord, Robert A.

doi:10.1007/s10006-012-0325-x

Cited by 11 publications

(3 citation statements)

References 48 publications

(47 reference statements)

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“…Tongue is the most commonly affected site in oral cavity, followed by the floor of the mouth 4 . Studies show that tumors on this site have a worse prognosis than other sites in the oral cavity due to their incomplete response to treatment strategies, resulting in lower survival rates 5 . Consequently, cancer of the oral cavity has higher mortality rates (50%) when compared to other types of cancer 1 …”

Section: Introductionmentioning

confidence: 99%

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

et al. 2020

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Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma.Objective:The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC).Methodology:In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005).Results:Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS.Conclusion:Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.

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Section: Introductionmentioning

confidence: 99%

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

et al. 2020

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“…Tongue cancers have lower survival rates probably due to incomplete response to treatment strategies. 3 Although the etiology is multifactorial, the major risk factors associated with its development are the use of tobacco products (smoking, chewing, and snuffing) with or without alcohol intake. The TNM classification is used clinically to define therapy and estimate its response and prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…Tongue cancers have lower survival rates probably due to incomplete response to treatment strategies. 3 …”

Section: Introductionmentioning

confidence: 99%

Lymphocytic Host Response and other Prognostic Factors in Early Stage Squamous Cell Carcinoma of Tongue: Retrospective Analysis from a Tertiary Cancer Center

Aswin

Swaminathan

Sundersingh

et al. 2023

South Asian J Cancer

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Introduction The tongue is the most common site of malignancy in the oral cavity, and squamous cell carcinoma is the commonest histology. The prognosis remains unfavorable despite treatment, resulting in higher mortality rates. Early stage carcinoma of the tongue is a distinct entity and is primarily treated with either surgery or radiotherapy. Various factors have been implicated in the prognosis of early stage tongue carcinomas. The main objective of this study is to access whether the lymphocytic host response (LHR) and other prognostic factors influence the survival. Patients and Methods The data of 129 patients with Stage I and Stage II (T1-2, N0) tongue cancer treated in our institute from January 2012 to December 2016 were retrospectively abstracted from the hospital case records. The various clinical and pathological factors were recorded. The Kaplan–Meier model was used for survival analysis. The disease-free survival (DFS) and the overall survival (OS) with respect to stage and LHR were calculated. Results On multivariate analysis, site of lesion, comorbidities, habits, grade of the tumor, perineural infiltration (PNI) did not influence the survival. The main factor which was found to be significant in DFS was LHR. The DFS was better for the patients who had lymphocytic infiltration of ≥ 70% (strong LHR) when compared with <70%(weak LHR) (p = 0.037). The OS with respect to stage (p = 0.608) and LHR (p = 0.164) was not found to be statistically significant. Conclusion The patients with weak LHR had less DFS when compared with patients with strong LHR. Larger studies are needed to evaluate whether adding adjuvant therapy may benefit the patients with weak LHR in early stage tongue cancer.

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Early Tongue Cancer

Lubek¹,

Dyalram²,

Suntharalingam³

et al. 2018

Oral, Head and Neck Oncology and Reconstructive Surgery

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Surgical management of the N0 neck in early stage T1–2 oral cancer; a personal perspective of early and late impalpable disease

Abstract: The lack of trials and studies stratifying NO and N +ve necks into early and late disease and comparing outcomes between these cohorts may explain the lack of clear-cut evidence regarding the role for elective neck dissection.

Cited by 11 publications

References 48 publications

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

Lymphocytic Host Response and other Prognostic Factors in Early Stage Squamous Cell Carcinoma of Tongue: Retrospective Analysis from a Tertiary Cancer Center

Early Tongue Cancer

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