Surgical Management of the Burn Wound and Use of Skin Substitutes

Kagan, Richard J.; Peck, Michael D.; Ahrenholz, David H.; Hickerson, William L.; Holmes, James H.; Korentager, Richard; Kraatz, James; Pollock, Kim

doi:10.1097/bcr.0b013e31827039a6

Cited by 98 publications

(85 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In cases where there is insufficient healthy, intact skin or the condition of the patient or wound precludes STSG placement, the standard of care is temporary coverage until definitive closure with STSG can occur. 1,7 In such cases, although additional products are available, the ''gold standard for achieving temporary wound coverage is allograft cadaver skin.'' 7 Temporary coverage reduces fluid loss and infection 1,15 and maintains a moist wound environment thereby promoting wound healing.…”

Section: Clinical Problem Addressedmentioning

confidence: 99%

“…7 Temporary coverage reduces fluid loss and infection 1,15 and maintains a moist wound environment thereby promoting wound healing. 1,16,17 This approach is limited by the availability of human cadaver skin, the non-trivial risk of disease transmission from cadaveric grafts, 18,19 and the relatively rapid rate at which these grafts begin to be rejected. 20 In patients for whom cadaver allograft is not available, other temporizing wound treatments must be used.…”

Section: Clinical Problem Addressedmentioning

confidence: 99%

“…Although many partial-thickness wounds heal without the need for autografting, the time required to heal deep partial-thickness burns is more than three weeks. 1 During this time, these wounds are at risk for infection and other complications that can delay definitive wound closure. [1][2][3] Due to significant morbidity in terms of healing time, infection, and scarring, deep partial-thickness and full-thickness burns are treated as a single clinical entity.…”

Section: Introductionmentioning

confidence: 99%

“…In those cases, the standard of care is temporary coverage with cadaver allograft until the wound can be definitively closed with STSG. 1,7 A living, full-thickness, allogeneic, human skin substitute generated from NIKS cells (NIKS-based BSS) to provide immediate wound coverage and promote wound healing has been recently developed and is being clinically tested. 8,9 This review will focus on the first-in-humans study of this BSS.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Due to significant morbidity in terms of healing time, infection, and scarring, deep partial-thickness and full-thickness burns are treated as a single clinical entity. 1,[4][5][6] Although the current management for these complex skin defects attempts to provide coverage with split-thickness skin graft (STSG) as quickly as possible, this is not always possible. In those cases, the standard of care is temporary coverage with cadaver allograft until the wound can be definitively closed with STSG.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Clinical Evaluation of NIKS-Based Bioengineered Skin Substitute Tissue in Complex Skin Defects: Phase I/IIa Clinical Trial Results

Schurr

Foster

Lokuta³

et al. 2012

Advances in Wound Care

View full text Add to dashboard Cite

Section: Clinical Problem Addressedmentioning

confidence: 99%

Section: Clinical Problem Addressedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical Evaluation of NIKS-Based Bioengineered Skin Substitute Tissue in Complex Skin Defects: Phase I/IIa Clinical Trial Results

Schurr

Foster

Lokuta³

et al. 2012

Advances in Wound Care

View full text Add to dashboard Cite

Liposomes with Silk Fibroin Hydrogel Core to Stabilize bFGF and Promote the Wound Healing of Mice with Deep Second‐Degree Scald

Chen

ZhuGe

et al. 2017

Adv Healthcare Materials

115

View full text Add to dashboard Cite

How to maintain the stability of basic fibroblast growth factor (bFGF) in wounds with massive wound fluids is important to accelerate wound healing. Here, a novel liposome with hydrogel core of silk fibroin (SF-LIP) is successfully developed by the common liposomal template, followed by gelation of liquid SF inside vesicle under sonication. SF-LIP is capable of encapsulating bFGF (SF-bFGF-LIP) with high efficiency, having a diameter of 99.8 ± 0.5 nm and zeta potential of -9.41 ± 0.10 mV. SF-LIP effectively improves the stability of bFGF in wound fluids. After 8 h of incubation with wound fluids at 37 °C, more than 50% of free bFGF are degraded, while only 18.6% of the encapsulated bFGF in SF-LIP are destroyed. Even after 3 d of preincubation with wound fluids, the cell proliferation activity and wound healing ability of SF-bFGF-LIP are still preserved but these are severely compromised for the conventional bFGF-liposome (bFGF-LIP). In vivo experiments reveal that SF-bFGF-LIP accelerates the wound closure of mice with deep second-degree scald. Moreover, due to the protective effect and enhanced penetration ability, SF-bFGF-LIP is very helpful to induce regeneration of vascular vessel in comparison with free bFGF or bFGF-LIP. The liposome with SF hydrogel core may be a potential carrier as growth factors for wound healing.

show abstract

Skin Thermal Management for Subcutaneous Photoelectric Conversion Reaching 500 mW

Lyu

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

Despite possessing higher tissue transmittance and maximum permissible exposure power density for skins relative to other electromagnetic waves, second near‐infrared light (1000∼1350 nm) is scarcely applicable to subcutaneous photoelectric conversion, owing to the companion of photothermal effect. Here, a skin thermal management is conceived to utmostly utilize the photothermal effect of a photovoltaic cell, which not only improves the photoelectric conversion efficiency but also eliminates the skin hyperthermia. In vivo, the output power can be higher than 500 mW with a photoelectric conversion efficiency as 9.4%. This output power is promising to recharge all the clinically applied implantable devices via wireless power transmission, e.g. clinical pacemakers (6∼200 μW), drug pump (0.5∼2 mW), cochlear (5∼40 mW), and wireless endo‐photo cameras (∼100 mW).This article is protected by copyright. All rights reserved

show abstract

Surgical Management of the Burn Wound and Use of Skin Substitutes

Cited by 98 publications

References 11 publications

Clinical Evaluation of NIKS-Based Bioengineered Skin Substitute Tissue in Complex Skin Defects: Phase I/IIa Clinical Trial Results

Clinical Evaluation of NIKS-Based Bioengineered Skin Substitute Tissue in Complex Skin Defects: Phase I/IIa Clinical Trial Results

Liposomes with Silk Fibroin Hydrogel Core to Stabilize bFGF and Promote the Wound Healing of Mice with Deep Second‐Degree Scald

Skin Thermal Management for Subcutaneous Photoelectric Conversion Reaching 500 mW

Contact Info

Product

Resources

About