Surgical Management of Recto-Sigmoid Hirschsprung’s Disease

Nouira, Faouzi; Ahmed, Yosra Ben; Sarrai, Nadia; Ghorbel, S; Jlidi, S.; Khemakhem, R.; Charieg, A.; Chaouachi, B.

doi:10.1080/00015458.2012.11680810

Cited by 3 publications

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“…Barium enema Barium enema was performed using standard technique by pediatric radiologists. 18 Briefly, diluted barium was infused rectally using a catheter, and x-ray images were obtained. All BE images were reviewed by the same pediatric radiologist.…”

Section: Protocolmentioning

confidence: 99%

High‐resolution anorectal manometry in newborns: normative values and diagnostic utility in Hirschsprung disease

Tang

Chen

et al. 2014

Neurogastroenterology Motil

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Section: Protocolmentioning

confidence: 99%

High‐resolution anorectal manometry in newborns: normative values and diagnostic utility in Hirschsprung disease

Tang

Chen

et al. 2014

Neurogastroenterology Motil

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“…1 The rectum is always affected and in 90% patients the disease extends up to rectosigmoid region. 2 The most widely accepted etiopathogenic hypothesis is based on a defect of craniocaudal migration of neuroblasts originating from the neural crest. 3 The clinical features of HD include: history of failure to pass meconium after 24 hours of age, constipation, abdominal distension, bilious vomiting and failure to thrive.…”

Section: Introductionmentioning

confidence: 99%

Comparative study between use of calretinin and synaptophysin immunostaining in diagnosis of Hirschsprung disease

et al. 2019

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Background: Hirschsprung disease (HD) is diagnosed by absence of ganglion cells in rectal biopsy. In some cases, standard methods fail to diagnose agangliosis. The aim of this study is to assess the diagnostic value of immunohistochemistry (IHC) of calretinin and synaptophysin compared to standard methods.Methods: This prospective cross section study was conducted in Menoufia University hospitals, Egypt spanning the period between October 2017 to December 2018. Rectal biopsies of the clinically suspected HD patients stained with calretinin and synaptophysin and their results compared to the standard hematoxylin and eosin (H&E) stained sections.Results: A total of 30 patients aged from 3 days to 2 years with a male to female ratio 11:4 were examined for rectal biopsies. Sections of 9 cases were diagnosed HD. In inadequate specimens, sensitivity and specificity of calretinin and synpatophysin (100%, 80%) and (100%, 85.71%) respectively were superior to the sensitivity (40%) and specificity (14%) of H&E. However, in adequate specimens, results of H&E, calretinin and synaptophysin were the same.Conclusions: Immunohistochemical expression of calretinin and synaptophysin were conclusive, diagnostic and superior to the results of H&E stained section in inadequate. However, in adequate specimens calretinin and synaptophysin were consistent and confirmatory to the results of H&E sections.

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“…The congenital indications are mainly anorectal malformation (ARM) and Hirschsprung's disease (HD), but the relative contribution of each as indication varies among various publications with HD more in some 1 , 4 , 5 and ARM more in others 2 , 3 , 6 , 7 . Incidence of colostomy for HD is dropping in some countries due to early presentation and performance of more single stage transanal pull-through procedures 8 , 9 , 10 but initial colostomy is still high in our environment 11 and other Low and Middle Income Countries 12 , 13 , 14 where late presentation is still rife. In the past there used to be many transverse 1 , 2 and loop colostomies 1 , 2 but the current trend seems to be more towards construction of defunctioning and sigmoid colostomies 3 , 14 , 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

Childhood colostomies: patterns, indications and outcomes in a Nigerian University Teaching Hospital

Ezomike¹,

Nwachukwu²,

Nwangwu³

et al. 2022

Afr H. Sci.

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Background: Most childhood colostomies are done for decompression or diversion in gastrointestinal tract congenital anomalies.Colostomy may be sited in the transverse or sigmoid colon as loop or defunctioning (divided) colostomies. Current pattern seems towards construction of more sigmoid and defunctioning colostomies. Aims: To evaluate the patterns, indications and outcomes of childhood colostomies. Patients and Methods: Retrospective chart review of all colostomies performed in children below 15 years from September 2010 to August 2020. Results: There were 104 colostomies (55males; 49females; 65 sigmoid; 39 transverse colostomies; 3 loop; 101 defunctioning colostomies. Anorecatal Malformation (ARM)was indication in 32 males and 41 females; age range 2 days to 13 years. Hirschsprung’s Disease (HD) was indication in 18 males and 4 females; age range 6 weeks to 15 years.In HD there were three loop colostomies (3/22) in transverse colon and 19 defunctioning colostomies (8 sigmoid, 11 transverse) while in ARM all 73 were defunctioning colostomies(P=0.01) In HD there were 14/22 transverse colostomies and 8/22 sigmoid colostomies while ARM had 24/73 transverse and 49/73sigmoid colostomies (P =0.013) In HD 91% colostomies were done beyond infancy while in ARM 93% were before one year(P<0.0001). Mortalities were notedin 1.9% patients. Conclusion: Commonest indication for colostomy is ARM. There are more defunctioning than loop colostomies, and more sigmoid than transverse colostomies. of most colostomies in ARM were during infancy while mostly beyond infancy in HD. Keywords: Childhood colostomies; oatterns; indications; outcomes.

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Surgical Management of Recto-Sigmoid Hirschsprung’s Disease

Cited by 3 publications

References 0 publications

High‐resolution anorectal manometry in newborns: normative values and diagnostic utility in Hirschsprung disease

High‐resolution anorectal manometry in newborns: normative values and diagnostic utility in Hirschsprung disease

Comparative study between use of calretinin and synaptophysin immunostaining in diagnosis of Hirschsprung disease

Childhood colostomies: patterns, indications and outcomes in a Nigerian University Teaching Hospital

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