Surgical management of radiation-induced angiosarcoma after breast conservation therapy

Jallali, Navid; James, Simon; Searle, A.G.; Ghattaura, Amar; Hayes, Andrew; Harris, Paul A.

doi:10.1016/j.amjsurg.2010.12.011

Cited by 56 publications

(72 citation statements)

References 29 publications

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“…Surgical resection, when possible, is the preferred initial strategy. However, surgery alone still results in local failure rates of 22%-92% and does depend on the extent of surgery; one series demonstrated an 80% and 50% recurrence after lumpectomy and mastectomy, respectively [3][4][5]. Results without surgery are poor, with one series demonstrating 91% persistent or recurrent disease [5].…”

Section: Introductionmentioning

confidence: 99%

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Intensification of Treatment for Angiosarcoma of the Breast with Accelerated Hyperfractionated Radiation, Hyperthermia, and Surgical Resection

Molitoris

Chhabra

Snider

et al. 2017

Cureus

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Angiosarcoma (AS) of the breast is a rare malignancy most commonly encountered as a secondary malignancy after the treatment of breast cancer with or without adjuvant radiation. The prognosis for secondary AS is poor, with reported five-year overall survival rates ranging from 10%-43%. The establishment of local control is vital to prognosis, yet patients often die with locally progressive disease. Multiple local therapies have been employed including surgery alone, surgery followed by radiation, and concurrent radiation and hyperthermia. Here, we report a case of secondary AS that occurred after breast conserving therapy and adjuvant radiation for ductal carcinoma in situ (DCIS). After initial surgical excision and subsequent local recurrence, our patient was treated with a novel treatment intensification strategy including neoadjuvant, accelerated hyperfractionated radiation with concurrent hyperthermia, followed by total mastectomy and flap reconstruction. The final pathologic evaluation demonstrated a near-complete response to induction thermoradiotherapy.

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Section: Introductionmentioning

confidence: 99%

“…It often presents with diffuse skin involvement and arises within or near the prior radiation field [1][2][3]. There is no proven effective chemotherapy regimen, and the majority of patients experience significant local morbidity.…”

Section: Introductionmentioning

confidence: 99%

Intensification of Treatment for Angiosarcoma of the Breast with Accelerated Hyperfractionated Radiation, Hyperthermia, and Surgical Resection

Molitoris

Chhabra

Snider

et al. 2017

Cureus

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“…It accounts for <0.04% of malignant neoplasms and typically arises in the parenchyma of the breast with occasional skin involvement (1)(2)(3). In contrast, secondary AS presents in older women (median age 67-71 years) following a median of 10.5 years after radiotherapy for breast cancer (1,(4)(5)(6). The median latency to presentation after radiotherapy in seven series ranges from 5 to 10 years (1).…”

Section: Introductionmentioning

confidence: 99%

“…by Borrman and the first case of secondary AS described in 1987 by Body et al, attempts have been made to correlate histological features and patterns of growth with outcome (2,4,5). The overall rarity of the condition has limited assessment of prognostic factors and best therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

“…It has been proposed that at radiation doses >50 Gy apoptosis occurs while at <50 Gy DNA damage and instability result. Sarcomas frequently occur at the edge of radiation fields where doses and tumor necrosis may be heterogeneous (4,5). When associated with chronic lymphedema and outside a radiated field, AS in an edematous limb after mastectomy and radiotherapy is referred to as Stewart-Treves syndrome (1,3).…”

Section: Introductionmentioning

confidence: 99%

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Primary and Secondary Angiosarcoma of the Breast

2016

Contemporary Diagnostic Radiology

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Angiosarcoma is a rare soft tissue tumor of the breast. It occurs in both a primary form without a known precursor, and a secondary form that has been associated to a history of irradiated breast tissue. These forms differ in many ways including median age, precipitating factors, and presentation. Both forms have a malignant behavior and a poor prognosis. The endeavor of this paper is to review what is known about the presentation, diagnostic and therapeutic modalities to date.

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Impact of specialist management on survival from radiation-associated angiosarcoma of the breast

Feinberg

Srinivasan

Singh

et al. 2018

British Journal of Surgery

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Surgical management of radiation-induced angiosarcoma after breast conservation therapy

Cited by 56 publications

References 29 publications

Intensification of Treatment for Angiosarcoma of the Breast with Accelerated Hyperfractionated Radiation, Hyperthermia, and Surgical Resection

Intensification of Treatment for Angiosarcoma of the Breast with Accelerated Hyperfractionated Radiation, Hyperthermia, and Surgical Resection

Primary and Secondary Angiosarcoma of the Breast

Impact of specialist management on survival from radiation-associated angiosarcoma of the breast

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