Surgical management of papillary thyroid carcinoma in childhood and adolescence: an Italian multicenter study on 250 patients

Spinelli, Claudio; Strambi, Silvia; Rossi, Leonardo; Bakkar, Sohail; Massimino, Maura; Ferrari, Andrea; Collini, Paola; Cecchetto, Giovanni; Bisogno, Gianni; Inserra, Alessandro; Bianco, Francesco; Miccoli, Paolo

doi:10.1007/s40618-016-0474-0

Cited by 45 publications

(49 citation statements)

References 16 publications

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“…A recent study on 250 children/AYAs with DTC concluded that treatment should be tailored to the patient's clinical presentation . Conservative surgery should be used for patients with tumors limited to one lobe, <2 cm in diameter, and with neither lymph node involvement nor distant metastasis.…”

Section: Differentiated Thyroid Carcinomamentioning

confidence: 99%

“…[3][4][5] A recent study on 250 children/AYAs with DTC concluded that treatment should be tailored to the patient's clinical presentation. 83 Conservative surgery should be used for patients with tumors limited to one lobe, <2 cm in diameter, and with neither lymph node involvement nor distant metastasis. All patients were alive after a median 5.8 years, and in appropriately selected patients, conservative surgery proved safe and oncologically effective.…”

Section: Conservative Managementmentioning

confidence: 99%

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Thyroid cancer in adolescents and young adults

Massimino

Evans

Podda

et al. 2018

Pediatric Blood & Cancer

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In adolescents and young adults, thyroid cancer accounts for 13% of all invasive neoplasms, being three times more frequent in females, but overdiagnosis and overtreatment are common. There are two therapeutic approaches, one radical and no longer preferred in all instances, and the other conservative. Permanent complications of surgery and metabolic irradiation can affect quality of life and carry an economic burden. The overall survival rate approaches 100% for patients with differentiated thyroid cancer regardless of the extent of treatment. Medullary thyroid carcinoma is a very different entity, occurring most frequently in the context of hereditary tumor susceptibility syndromes.

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Section: Differentiated Thyroid Carcinomamentioning

confidence: 99%

Section: Conservative Managementmentioning

confidence: 99%

Thyroid cancer in adolescents and young adults

Massimino

Evans

Podda

et al. 2018

Pediatric Blood & Cancer

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“…If involvement of lateral cervical lymph nodes is suspected clinically or by preoperative imaging studies, this should be confirmed by FNA prior to undertaking lateral neck lymph node dissection. Surgery, especially if a compartment‐focused lymph node resection is indicated, should ideally be performed by an experienced surgeon to minimize complications . The ATA guidelines task force defines an experienced, high‐volume surgeon as one who performs at least 30 cervical surgeries annually …”

Section: Surgical Approachmentioning

confidence: 99%

Management of pediatric differentiated thyroid cancer: An overview for the pediatric oncologist

Prasad

Mahajan

Hawkins

et al. 2020

Pediatric Blood & Cancer

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Differentiated thyroid cancer (DTC) is the most common childhood thyroid malignancy. The standard of care for pediatric DTC is total thyroidectomy followed by radioactive iodine (RAI) treatment when indicated. Molecular changes and potential therapeutic targets have been recently described in pediatric thyroid cancer. Pediatric oncologists are increasingly involved in the evaluation of thyroid nodules in childhood cancer survivors and in the management of advanced thyroid cancer. In 2015, the American Thyroid Association published management guidelines for children with DTC. We provide an overview of the current standard of care and highlight available targeted therapies for progressive or RAI refractory DTC. K E Y W O R D Schildhood, differentiated thyroid cancer, papillary thyroid carcinoma, pediatric, radioactive iodine

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“…In a national multicenter retrospective review of 250 pediatric patients in Italy treated for papillary thyroid carcinoma in a 14-year period, it was concluded that total thyroidectomy seems to be an overly radical approach [12]. The rate of recurrent disease was 12 % (30/250) with the vast majority of recurrences (96.6 %) occurring in the total thyroidectomy group.…”

Section: Improvements In Selected Areas Of Pediatric Oncology Advancementioning

confidence: 99%

Modern surgical strategies in pediatric oncology

Sk¹,

Gupta²

2016

Medical news of the North Caucasus

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all india institute of medical sciences, new Delhi, india СОВРЕМЕННЫЕ ХИРуРГИчЕСКИЕ СТРАТЕГИИ В ДЕТСКОй ОНКОЛОГИИ Ш. Шарма, Д. К. Гупта Всеиндийский институт медицинских наук, Нью-Дели, ИндияIn review showed modern surgical strategies in selected areas of pediatric oncology. The newer energy sources have contributed to less blood and thus fewer complications following major resections. Robotic, endoscopy and stereotactic surgery have been the major advances in the treatment of pediatric tumours. There is more dependence on the use of chemotherapy, newer protocols with less toxic drugs and for shorter duration.In a review of the current literature assesses the recently discovered phenomenon and the toxicity of anesthetics in the developing child brain. The ways of diagnostics of morphological and functional abnormalities of brain activity in children. Provides indisputable data on the possibility of this type of interactions taking into account the mechanism of action of anesthetics. Comparative characteristics of strength toxic effects on children's brain different types of inhalation and non-inhalation anesthetics. There is a comparison of the degree of toxic impact on the brain at single and repeated exposure of anesthesia. Emphasizes the lack of information and especially objective data visualization of degenerative changes in children's brain due to ethical constraints and the impossibility of obtaining samples for biopsy. The conclusion about the appropriateness of expectant surgical tactics in the absence of urgent indications for surgical intervention to 4 years of a child's life. Also, our patients need more researches in this direction.В обзоре дается оценка недавно обнаруженному феномену токсичности анестетиков для развивающегося детского мозга. Определяются способы диагностики морфофункциональных нарушений мозговой активности у детей. Приводятся неоспоримые данные о возможности такого вида взаимодействий с учетом механизма действия анестетиков. Дается сравнительная характеристика силы токсического воздействия на детский

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Surgical management of papillary thyroid carcinoma in childhood and adolescence: an Italian multicenter study on 250 patients

Abstract: Pediatric patients are likely to benefit from a tailored surgical strategy. Uniformly offering patients total thyroidectomy seems to be an overly radical approach.

Cited by 45 publications

References 16 publications

Thyroid cancer in adolescents and young adults

Thyroid cancer in adolescents and young adults

Management of pediatric differentiated thyroid cancer: An overview for the pediatric oncologist

Modern surgical strategies in pediatric oncology

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