Surgical Management of Pancreatic Neuroendocrine Tumors

Abstract

The incidence of pancreatic neuroendocrine tumors has significantly increased for the last decades. Patients with multiple pancreatic neuroendocrine tumors require special attention to the diagnosis and treatment algorithms. The aim is to show possible treatment approaches for patients with multiple pancreatic neuroendocrine tumors. Materials and methods. 26 patients with multiple pancreatic neuroendocrine tumors were managed in the abdominal surgery department of Sechenov University for the last 20 years. Results. The rate of multiple tumors was 9% for sporadic tumors and 36.5% among patients with MEN-1. Sensitivity of the imaging techniques was significantly lower than in solitary insulinomas. Most patients underwent parenchymasparing procedures. Total pancreatectomy was performed only in two cases. Conclusion. Accurate imaging and identification of hormone-secreting tumors allows to offer patients parenchyma-sparing surgery and to provide more personalized approach to the treatment of patients with multiple pancreatic neuroendocrine tumors.