Surgical Management of Isolated Bilateral Adrenal Metastases from Colon Carcinoma Causing Adrenal Insufficiency

Crisci, Alfonso; Cartei, G.; Antoni, P De; Giannarini, Gianluca; Moro, U; Selli, Cesare

doi:10.1159/000050963

Cited by 9 publications

(12 citation statements)

References 14 publications

(27 reference statements)

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“…Laparoscopic adrenalectomy has become the 'gold standard' of treatment for benign adrenal masses (24). However, laparoscopy remains a controversial approach for known malignant diseases (3,23,25). For example, a previous study claims that adrenalectomy has not proven beneficial in the treatment of patients with adrenal metastases following resection of colorectal hepatic metastases (26).…”

Section: Discussionmentioning

confidence: 99%

Adrenalectomy may increase survival of patients with adrenal metastases

Zheng

Zhang

et al. 2012

Oncol Lett

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Abstract. The much improved diagnostic accuracy of computed tomography (CT) and positron emission tomography (PET) has enabled urologists and medical oncologists to identify and treat more patients with metastases to the adrenal glands. The aim of this retrospective study was to analyze the clinical aspects of adrenal metastases in a series of patients and to evaluate the effect of adrenalectomy, by laparoscopic or open resection of adrenal metastases, on the survival of these patients. A total of 47 patients (32 males, 15 females) with metastatic disease in the adrenal glands were included in this study. Type B ultrasound and CT were utilized to diagnose the adrenal metastases. Open resection was performed in certain patients with primary tumor and adrenal metastasis. The results showed that adrenal metastases in these patients had various origins, including lung carcinoma, kidney carcinoma, breast cancer, melanoma and other uncharacterized carcinomas. The median survival of the 37 followed-up patients was 29.7±3.23 months (range, 2-62) after the diagnosis/surgical removal of adrenal metastases. The survival rate of the 31 patients with surgically removed adrenal metastases (average, 34.2±4.7 months; range 2-62) was higher than the survival rates of the 6 patients without surgical resection (average, 6.3±2.7 months; range, 4-8). The results of this study are in support of adrenalectomy for patients with adrenal metastases.

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Section: Discussionmentioning

confidence: 99%

Adrenalectomy may increase survival of patients with adrenal metastases

Zheng

Zhang

et al. 2012

Oncol Lett

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“…It is rare for a patient to present with adrenal insufficiency secondary to bilateral adrenal gland metastasis from a malignant colorectal tumor [3], [4], [5], [6], [7]. The survival rate of patients with cancer is increasing, and improvements in imaging techniques have resulted in increased antemortem recognition of adrenal gland metastases.…”

Section: Discussionmentioning

confidence: 99%

“…It develops when >90% of adrenal tissue is destroyed [2]. It is rare for a patient to present with Addison’s disease secondary to bilateral adrenal gland metastases from a malignant colorectal tumor; only five cases have been published in the English literature [3], [4], [5], [6], [7]. Herein, we describe a sixth case of adrenal insufficiency in a patient with bilateral adrenal gland metastasis from rectal cancer, based on Surgical Case Report (SCARE) Guidelines [8].…”

Section: Introductionmentioning

confidence: 99%

Adrenal failure due to bilateral adrenal metastasis of rectal cancer: A case report

Imaoka¹,

Kuranishi²,

Ogawa³

et al. 2017

International Journal of Surgery Case Reports

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“…16 Ultimately, the ensuing insufficiency, and that after bilateral adrenalectomy, can be controlled with hormone replacement therapy. 16,17 In conclusion, the management of adrenal metastasis from gastric cancer is controversial, and the rarity of such cases makes a randomized prospective trial comparing surgery with nonsurgical management unlikely. Although our patient's initial disease-free interval was less than 6 months and the adrenal metastasis was not solitary, the subsequent disease-free interval of 41 months and the current disease-free interval of longer than 3 years may justify the surgical resection of some metastatic lesions.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Survival After Resection of Metachronous Bilateral Adrenal Metastases of Mucinous Gastric Carcinoma: Report of a Case

Mokuno

Katayama²,

Ogura³

et al. 2006

Surg Today

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We report a case of metachronous bilateral adrenal metastases from mucinous adenocarcinoma of the stomach. A 68-year-old man who had undergone surgery for advanced gastric cancer 5 months earlier had a follow-up computed tomography (CT) scan, which showed a right adrenal tumor. We performed a right adrenalectomy, and histopathological examination revealed a mucinous adenocarcinoma with features consistent with those of gastric cancer. A routine follow-up CT scan done 41 months after the right adrenalectomy showed a left adrenal mass. Chemotherapy had no apparent effect, and left adrenalectomy was performed 65 months after the right adrenalectomy. Histopathological examination also revealed a metastasis from gastric cancer. The patient was alive without recurrence 40 months after the left adrenalectomy. This case suggests that resection of adrenal metastasis from gastric cancer is an effective treatment option that may prolong survival in selected patients.

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Surgical Management of Isolated Bilateral Adrenal Metastases from Colon Carcinoma Causing Adrenal Insufficiency

Cited by 9 publications

References 14 publications

Adrenalectomy may increase survival of patients with adrenal metastases

Adrenalectomy may increase survival of patients with adrenal metastases

Adrenal failure due to bilateral adrenal metastasis of rectal cancer: A case report

Long-Term Survival After Resection of Metachronous Bilateral Adrenal Metastases of Mucinous Gastric Carcinoma: Report of a Case

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